The effect of amoxicillin on dental enamel development in vivo
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Oral Research |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242020000100287 |
Resumo: | Abstract The exposure to amoxicillin has been associated with molar incisor hypomineralization. This study aimed to determine if amoxicillin disturbs the enamel mineralization in in vivo experiments. Fifteen pregnant rats were randomly assigned into three groups to received daily phosphatase-buffered saline or amoxicillin as either 100 or 500 mg/kg. Mice received treatment from day 13 of pregnancy to day 40 postnatal. After birth, the offsprings from each litter continued to receive the same treatment according to their respective group. Calcium (Ca) and phosphorus (P) content in the dental hard tissues were analyzed from 60 upper first molars and 60 upper incisors by the complexometric titration method and colorimetric analysis using a spectrophotometer at 680 nm, respectively. Lower incisors were analyzed by X-ray microtomography, it was measured the electron density of lingual and buccal enamel, and the enamel and dentin thickness. Differences in Ca and P content and electron density among the groups were analyzed by one-way ANOVA. There was no significant difference on enamel electron density and thickness among the groups (p > 0.05). However, in incisors, the higher dose of amoxicillin decreased markedly the electron density in some rats. There were no statistically significant differences in Ca (p = 0.180) or P content (p = 0.054), although the higher dose of amoxicillin could affect the enamel in some animals. The amoxicillin did not significantly alter the enamel mineralization and thickness in rats. |
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The effect of amoxicillin on dental enamel development in vivoX-Ray MicrotomographyDental EnamelAmoxicillinAmelogenesisDental Enamel HypoplasiaAbstract The exposure to amoxicillin has been associated with molar incisor hypomineralization. This study aimed to determine if amoxicillin disturbs the enamel mineralization in in vivo experiments. Fifteen pregnant rats were randomly assigned into three groups to received daily phosphatase-buffered saline or amoxicillin as either 100 or 500 mg/kg. Mice received treatment from day 13 of pregnancy to day 40 postnatal. After birth, the offsprings from each litter continued to receive the same treatment according to their respective group. Calcium (Ca) and phosphorus (P) content in the dental hard tissues were analyzed from 60 upper first molars and 60 upper incisors by the complexometric titration method and colorimetric analysis using a spectrophotometer at 680 nm, respectively. Lower incisors were analyzed by X-ray microtomography, it was measured the electron density of lingual and buccal enamel, and the enamel and dentin thickness. Differences in Ca and P content and electron density among the groups were analyzed by one-way ANOVA. There was no significant difference on enamel electron density and thickness among the groups (p > 0.05). However, in incisors, the higher dose of amoxicillin decreased markedly the electron density in some rats. There were no statistically significant differences in Ca (p = 0.180) or P content (p = 0.054), although the higher dose of amoxicillin could affect the enamel in some animals. The amoxicillin did not significantly alter the enamel mineralization and thickness in rats.Sociedade Brasileira de Pesquisa Odontológica - SBPqO2020-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242020000100287Brazilian Oral Research v.34 2020reponame:Brazilian Oral Researchinstname:Sociedade Brasileira de Pesquisa Odontológica (SBPqO)instacron:SBPQO10.1590/1807-3107bor-2020.vol34.0116info:eu-repo/semantics/openAccessFELTRIN-SOUZA,JulianaJEREMIAS,FabianoALALUUSUA,SatuSAHLBERG,CarinSANTOS-PINTO,LourdesJERNVALL,JukkaSOVA,SusannaCORDEIRO,Rita de Cássia LoiolaCERRI,Paulo Sérgioeng2020-09-14T00:00:00Zoai:scielo:S1806-83242020000100287Revistahttps://www.scielo.br/j/bor/https://old.scielo.br/oai/scielo-oai.phppob@edu.usp.br||bor@sbpqo.org.br1807-31071806-8324opendoar:2020-09-14T00:00Brazilian Oral Research - Sociedade Brasileira de Pesquisa Odontológica (SBPqO)false |
dc.title.none.fl_str_mv |
The effect of amoxicillin on dental enamel development in vivo |
title |
The effect of amoxicillin on dental enamel development in vivo |
spellingShingle |
The effect of amoxicillin on dental enamel development in vivo FELTRIN-SOUZA,Juliana X-Ray Microtomography Dental Enamel Amoxicillin Amelogenesis Dental Enamel Hypoplasia |
title_short |
The effect of amoxicillin on dental enamel development in vivo |
title_full |
The effect of amoxicillin on dental enamel development in vivo |
title_fullStr |
The effect of amoxicillin on dental enamel development in vivo |
title_full_unstemmed |
The effect of amoxicillin on dental enamel development in vivo |
title_sort |
The effect of amoxicillin on dental enamel development in vivo |
author |
FELTRIN-SOUZA,Juliana |
author_facet |
FELTRIN-SOUZA,Juliana JEREMIAS,Fabiano ALALUUSUA,Satu SAHLBERG,Carin SANTOS-PINTO,Lourdes JERNVALL,Jukka SOVA,Susanna CORDEIRO,Rita de Cássia Loiola CERRI,Paulo Sérgio |
author_role |
author |
author2 |
JEREMIAS,Fabiano ALALUUSUA,Satu SAHLBERG,Carin SANTOS-PINTO,Lourdes JERNVALL,Jukka SOVA,Susanna CORDEIRO,Rita de Cássia Loiola CERRI,Paulo Sérgio |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
FELTRIN-SOUZA,Juliana JEREMIAS,Fabiano ALALUUSUA,Satu SAHLBERG,Carin SANTOS-PINTO,Lourdes JERNVALL,Jukka SOVA,Susanna CORDEIRO,Rita de Cássia Loiola CERRI,Paulo Sérgio |
dc.subject.por.fl_str_mv |
X-Ray Microtomography Dental Enamel Amoxicillin Amelogenesis Dental Enamel Hypoplasia |
topic |
X-Ray Microtomography Dental Enamel Amoxicillin Amelogenesis Dental Enamel Hypoplasia |
description |
Abstract The exposure to amoxicillin has been associated with molar incisor hypomineralization. This study aimed to determine if amoxicillin disturbs the enamel mineralization in in vivo experiments. Fifteen pregnant rats were randomly assigned into three groups to received daily phosphatase-buffered saline or amoxicillin as either 100 or 500 mg/kg. Mice received treatment from day 13 of pregnancy to day 40 postnatal. After birth, the offsprings from each litter continued to receive the same treatment according to their respective group. Calcium (Ca) and phosphorus (P) content in the dental hard tissues were analyzed from 60 upper first molars and 60 upper incisors by the complexometric titration method and colorimetric analysis using a spectrophotometer at 680 nm, respectively. Lower incisors were analyzed by X-ray microtomography, it was measured the electron density of lingual and buccal enamel, and the enamel and dentin thickness. Differences in Ca and P content and electron density among the groups were analyzed by one-way ANOVA. There was no significant difference on enamel electron density and thickness among the groups (p > 0.05). However, in incisors, the higher dose of amoxicillin decreased markedly the electron density in some rats. There were no statistically significant differences in Ca (p = 0.180) or P content (p = 0.054), although the higher dose of amoxicillin could affect the enamel in some animals. The amoxicillin did not significantly alter the enamel mineralization and thickness in rats. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242020000100287 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242020000100287 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1807-3107bor-2020.vol34.0116 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Pesquisa Odontológica - SBPqO |
publisher.none.fl_str_mv |
Sociedade Brasileira de Pesquisa Odontológica - SBPqO |
dc.source.none.fl_str_mv |
Brazilian Oral Research v.34 2020 reponame:Brazilian Oral Research instname:Sociedade Brasileira de Pesquisa Odontológica (SBPqO) instacron:SBPQO |
instname_str |
Sociedade Brasileira de Pesquisa Odontológica (SBPqO) |
instacron_str |
SBPQO |
institution |
SBPQO |
reponame_str |
Brazilian Oral Research |
collection |
Brazilian Oral Research |
repository.name.fl_str_mv |
Brazilian Oral Research - Sociedade Brasileira de Pesquisa Odontológica (SBPqO) |
repository.mail.fl_str_mv |
pob@edu.usp.br||bor@sbpqo.org.br |
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1750318327181344768 |