Current trends of genetics in apical periodontitis research

Detalhes bibliográficos
Autor(a) principal: Küchler,Erika Calvano
Data de Publicação: 2018
Outros Autores: Mazzi-Chaves,Jardel Francisco, Antunes,Leonardo Santos, Kirschneck,Christian, Baratto-Filho,Flares, Sousa-Neto,Manoel Damião
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Oral Research
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242018000500607
Resumo: Abstract: Genetics is an emerging topic in endodontic research focusing on the host response regarding the pathogenesis of apical periodontitis (AP). A number of genetic epidemiological studies carried out by many investigators worldwide have shown evidence of an association between certain candidate genes and AP. Some studies have been conducted on knockout mice with a deficiency in certain proteins, leading to more or less severe AP, and thus suggesting a pivotal role of these genes in AP pathogenesis. Other research has evaluated the association between genetic polymorphisms in humans with different AP aspects; these studies pointed out that genetic polymorphisms in some candidate genes are involved in inter-individual variations in their response to AP. Therefore, the objective of this report was to provide an updated overview of the genes involved in AP pathogenesis, with a focus on the most relevant candidate genes.
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spelling Current trends of genetics in apical periodontitis researchPeriapical PeriodontitisPolymorphismsGeneticGenesPathologyEndodonticsAbstract: Genetics is an emerging topic in endodontic research focusing on the host response regarding the pathogenesis of apical periodontitis (AP). A number of genetic epidemiological studies carried out by many investigators worldwide have shown evidence of an association between certain candidate genes and AP. Some studies have been conducted on knockout mice with a deficiency in certain proteins, leading to more or less severe AP, and thus suggesting a pivotal role of these genes in AP pathogenesis. Other research has evaluated the association between genetic polymorphisms in humans with different AP aspects; these studies pointed out that genetic polymorphisms in some candidate genes are involved in inter-individual variations in their response to AP. Therefore, the objective of this report was to provide an updated overview of the genes involved in AP pathogenesis, with a focus on the most relevant candidate genes.Sociedade Brasileira de Pesquisa Odontológica - SBPqO2018-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242018000500607Brazilian Oral Research v.32 suppl.1 2018reponame:Brazilian Oral Researchinstname:Sociedade Brasileira de Pesquisa Odontológica (SBPqO)instacron:SBPQO10.1590/1807-3107bor-2018.vol32.0072info:eu-repo/semantics/openAccessKüchler,Erika CalvanoMazzi-Chaves,Jardel FranciscoAntunes,Leonardo SantosKirschneck,ChristianBaratto-Filho,FlaresSousa-Neto,Manoel Damiãoeng2018-10-10T00:00:00Zoai:scielo:S1806-83242018000500607Revistahttps://www.scielo.br/j/bor/https://old.scielo.br/oai/scielo-oai.phppob@edu.usp.br||bor@sbpqo.org.br1807-31071806-8324opendoar:2018-10-10T00:00Brazilian Oral Research - Sociedade Brasileira de Pesquisa Odontológica (SBPqO)false
dc.title.none.fl_str_mv Current trends of genetics in apical periodontitis research
title Current trends of genetics in apical periodontitis research
spellingShingle Current trends of genetics in apical periodontitis research
Küchler,Erika Calvano
Periapical Periodontitis
Polymorphisms
Genetic
Genes
Pathology
Endodontics
title_short Current trends of genetics in apical periodontitis research
title_full Current trends of genetics in apical periodontitis research
title_fullStr Current trends of genetics in apical periodontitis research
title_full_unstemmed Current trends of genetics in apical periodontitis research
title_sort Current trends of genetics in apical periodontitis research
author Küchler,Erika Calvano
author_facet Küchler,Erika Calvano
Mazzi-Chaves,Jardel Francisco
Antunes,Leonardo Santos
Kirschneck,Christian
Baratto-Filho,Flares
Sousa-Neto,Manoel Damião
author_role author
author2 Mazzi-Chaves,Jardel Francisco
Antunes,Leonardo Santos
Kirschneck,Christian
Baratto-Filho,Flares
Sousa-Neto,Manoel Damião
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Küchler,Erika Calvano
Mazzi-Chaves,Jardel Francisco
Antunes,Leonardo Santos
Kirschneck,Christian
Baratto-Filho,Flares
Sousa-Neto,Manoel Damião
dc.subject.por.fl_str_mv Periapical Periodontitis
Polymorphisms
Genetic
Genes
Pathology
Endodontics
topic Periapical Periodontitis
Polymorphisms
Genetic
Genes
Pathology
Endodontics
description Abstract: Genetics is an emerging topic in endodontic research focusing on the host response regarding the pathogenesis of apical periodontitis (AP). A number of genetic epidemiological studies carried out by many investigators worldwide have shown evidence of an association between certain candidate genes and AP. Some studies have been conducted on knockout mice with a deficiency in certain proteins, leading to more or less severe AP, and thus suggesting a pivotal role of these genes in AP pathogenesis. Other research has evaluated the association between genetic polymorphisms in humans with different AP aspects; these studies pointed out that genetic polymorphisms in some candidate genes are involved in inter-individual variations in their response to AP. Therefore, the objective of this report was to provide an updated overview of the genes involved in AP pathogenesis, with a focus on the most relevant candidate genes.
publishDate 2018
dc.date.none.fl_str_mv 2018-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242018000500607
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242018000500607
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/1807-3107bor-2018.vol32.0072
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Pesquisa Odontológica - SBPqO
publisher.none.fl_str_mv Sociedade Brasileira de Pesquisa Odontológica - SBPqO
dc.source.none.fl_str_mv Brazilian Oral Research v.32 suppl.1 2018
reponame:Brazilian Oral Research
instname:Sociedade Brasileira de Pesquisa Odontológica (SBPqO)
instacron:SBPQO
instname_str Sociedade Brasileira de Pesquisa Odontológica (SBPqO)
instacron_str SBPQO
institution SBPQO
reponame_str Brazilian Oral Research
collection Brazilian Oral Research
repository.name.fl_str_mv Brazilian Oral Research - Sociedade Brasileira de Pesquisa Odontológica (SBPqO)
repository.mail.fl_str_mv pob@edu.usp.br||bor@sbpqo.org.br
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