Symptom variability over the course of the day in patients with stable COPD in Brazil: a real-world observational study

Detalhes bibliográficos
Autor(a) principal: Cukier,Alberto
Data de Publicação: 2020
Outros Autores: Godoy,Irma de, Costa,Claudia Henrique da, Rubin,Adalberto Sperb, Gregorio,Marcelo Gervilla, Albuquerque Neto,Aldo Agra de, Lima,Marina Andrade, Pereira,Monica Corso, Tanni,Suzana Erico, Athanazio,Rodrigo Abensur, Bessa,Elizabeth Jauhar Cardoso, Wehrmeister,Fernando Cesar, Lourenco,Cristina Bassi, Menezes,Ana Maria Baptista
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Jornal Brasileiro de Pneumologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132020000300200
Resumo: ABSTRACT Objective: To analyze symptoms at different times of day in patients with COPD. Methods: This was a multicenter, cross-sectional observational study conducted at eight centers in Brazil. We evaluated morning, daytime, and nighttime symptoms in patients with stable COPD. Results: We included 593 patients under regular treatment, of whom 309 (52.1%) were male and 92 (15.5%) were active smokers. The mean age was 67.7 years, and the mean FEV1 was 49.4% of the predicted value. In comparison with the patients who had mild or moderate symptoms, the 183 (30.8%) with severe symptoms were less physically active (p = 0.002), had greater airflow limitation (p < 0.001), had more outpatient exacerbations (p = 0.002) and more inpatient exacerbations (p = 0.043), as well as scoring worse on specific instruments. The most common morning and nighttime symptoms were dyspnea (in 45.2% and 33.1%, respectively), cough (in 37.5% and 33.3%, respectively), and wheezing (in 24.4% and 27.0%, respectively). The intensity of daytime symptoms correlated strongly with that of morning symptoms (r = 0.65, p < 0.001) and that of nighttime symptoms (r = 0.60, p < 0.001), as well as with the COPD Assessment Test score (r = 0.62; p < 0.001), although it showed only a weak correlation with FEV1 (r = −0.205; p < 0.001). Conclusions: Dyspnea was more common in the morning than at night. Having morning or nighttime symptoms was associated with greater daytime symptom severity. Symptom intensity was strongly associated with poor quality of life and with the frequency of exacerbations, although it was weakly associated with airflow limitation.
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spelling Symptom variability over the course of the day in patients with stable COPD in Brazil: a real-world observational studyPulmonary disease, chronic obstructiveSigns and symptoms, respiratoryQuality of lifeDisease progressionBrazilABSTRACT Objective: To analyze symptoms at different times of day in patients with COPD. Methods: This was a multicenter, cross-sectional observational study conducted at eight centers in Brazil. We evaluated morning, daytime, and nighttime symptoms in patients with stable COPD. Results: We included 593 patients under regular treatment, of whom 309 (52.1%) were male and 92 (15.5%) were active smokers. The mean age was 67.7 years, and the mean FEV1 was 49.4% of the predicted value. In comparison with the patients who had mild or moderate symptoms, the 183 (30.8%) with severe symptoms were less physically active (p = 0.002), had greater airflow limitation (p < 0.001), had more outpatient exacerbations (p = 0.002) and more inpatient exacerbations (p = 0.043), as well as scoring worse on specific instruments. The most common morning and nighttime symptoms were dyspnea (in 45.2% and 33.1%, respectively), cough (in 37.5% and 33.3%, respectively), and wheezing (in 24.4% and 27.0%, respectively). The intensity of daytime symptoms correlated strongly with that of morning symptoms (r = 0.65, p < 0.001) and that of nighttime symptoms (r = 0.60, p < 0.001), as well as with the COPD Assessment Test score (r = 0.62; p < 0.001), although it showed only a weak correlation with FEV1 (r = −0.205; p < 0.001). Conclusions: Dyspnea was more common in the morning than at night. Having morning or nighttime symptoms was associated with greater daytime symptom severity. Symptom intensity was strongly associated with poor quality of life and with the frequency of exacerbations, although it was weakly associated with airflow limitation.Sociedade Brasileira de Pneumologia e Tisiologia2020-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132020000300200Jornal Brasileiro de Pneumologia v.46 n.3 2020reponame:Jornal Brasileiro de Pneumologia (Online)instname:Sociedade Brasileira de Pneumologia e Tisiologia (SBPT)instacron:SBPT10.36416/1806-3756/e20190223info:eu-repo/semantics/openAccessCukier,AlbertoGodoy,Irma deCosta,Claudia Henrique daRubin,Adalberto SperbGregorio,Marcelo GervillaAlbuquerque Neto,Aldo Agra deLima,Marina AndradePereira,Monica CorsoTanni,Suzana EricoAthanazio,Rodrigo AbensurBessa,Elizabeth Jauhar CardosoWehrmeister,Fernando CesarLourenco,Cristina BassiMenezes,Ana Maria Baptistaeng2019-12-17T00:00:00Zoai:scielo:S1806-37132020000300200Revistahttp://www.jornaldepneumologia.com.br/default.aspONGhttps://old.scielo.br/oai/scielo-oai.php||jbp@jbp.org.br|| jpneumo@jornaldepneumologia.com.br1806-37561806-3713opendoar:2019-12-17T00:00Jornal Brasileiro de Pneumologia (Online) - Sociedade Brasileira de Pneumologia e Tisiologia (SBPT)false
dc.title.none.fl_str_mv Symptom variability over the course of the day in patients with stable COPD in Brazil: a real-world observational study
title Symptom variability over the course of the day in patients with stable COPD in Brazil: a real-world observational study
spellingShingle Symptom variability over the course of the day in patients with stable COPD in Brazil: a real-world observational study
Cukier,Alberto
Pulmonary disease, chronic obstructive
Signs and symptoms, respiratory
Quality of life
Disease progression
Brazil
title_short Symptom variability over the course of the day in patients with stable COPD in Brazil: a real-world observational study
title_full Symptom variability over the course of the day in patients with stable COPD in Brazil: a real-world observational study
title_fullStr Symptom variability over the course of the day in patients with stable COPD in Brazil: a real-world observational study
title_full_unstemmed Symptom variability over the course of the day in patients with stable COPD in Brazil: a real-world observational study
title_sort Symptom variability over the course of the day in patients with stable COPD in Brazil: a real-world observational study
author Cukier,Alberto
author_facet Cukier,Alberto
Godoy,Irma de
Costa,Claudia Henrique da
Rubin,Adalberto Sperb
Gregorio,Marcelo Gervilla
Albuquerque Neto,Aldo Agra de
Lima,Marina Andrade
Pereira,Monica Corso
Tanni,Suzana Erico
Athanazio,Rodrigo Abensur
Bessa,Elizabeth Jauhar Cardoso
Wehrmeister,Fernando Cesar
Lourenco,Cristina Bassi
Menezes,Ana Maria Baptista
author_role author
author2 Godoy,Irma de
Costa,Claudia Henrique da
Rubin,Adalberto Sperb
Gregorio,Marcelo Gervilla
Albuquerque Neto,Aldo Agra de
Lima,Marina Andrade
Pereira,Monica Corso
Tanni,Suzana Erico
Athanazio,Rodrigo Abensur
Bessa,Elizabeth Jauhar Cardoso
Wehrmeister,Fernando Cesar
Lourenco,Cristina Bassi
Menezes,Ana Maria Baptista
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Cukier,Alberto
Godoy,Irma de
Costa,Claudia Henrique da
Rubin,Adalberto Sperb
Gregorio,Marcelo Gervilla
Albuquerque Neto,Aldo Agra de
Lima,Marina Andrade
Pereira,Monica Corso
Tanni,Suzana Erico
Athanazio,Rodrigo Abensur
Bessa,Elizabeth Jauhar Cardoso
Wehrmeister,Fernando Cesar
Lourenco,Cristina Bassi
Menezes,Ana Maria Baptista
dc.subject.por.fl_str_mv Pulmonary disease, chronic obstructive
Signs and symptoms, respiratory
Quality of life
Disease progression
Brazil
topic Pulmonary disease, chronic obstructive
Signs and symptoms, respiratory
Quality of life
Disease progression
Brazil
description ABSTRACT Objective: To analyze symptoms at different times of day in patients with COPD. Methods: This was a multicenter, cross-sectional observational study conducted at eight centers in Brazil. We evaluated morning, daytime, and nighttime symptoms in patients with stable COPD. Results: We included 593 patients under regular treatment, of whom 309 (52.1%) were male and 92 (15.5%) were active smokers. The mean age was 67.7 years, and the mean FEV1 was 49.4% of the predicted value. In comparison with the patients who had mild or moderate symptoms, the 183 (30.8%) with severe symptoms were less physically active (p = 0.002), had greater airflow limitation (p < 0.001), had more outpatient exacerbations (p = 0.002) and more inpatient exacerbations (p = 0.043), as well as scoring worse on specific instruments. The most common morning and nighttime symptoms were dyspnea (in 45.2% and 33.1%, respectively), cough (in 37.5% and 33.3%, respectively), and wheezing (in 24.4% and 27.0%, respectively). The intensity of daytime symptoms correlated strongly with that of morning symptoms (r = 0.65, p < 0.001) and that of nighttime symptoms (r = 0.60, p < 0.001), as well as with the COPD Assessment Test score (r = 0.62; p < 0.001), although it showed only a weak correlation with FEV1 (r = −0.205; p < 0.001). Conclusions: Dyspnea was more common in the morning than at night. Having morning or nighttime symptoms was associated with greater daytime symptom severity. Symptom intensity was strongly associated with poor quality of life and with the frequency of exacerbations, although it was weakly associated with airflow limitation.
publishDate 2020
dc.date.none.fl_str_mv 2020-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132020000300200
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132020000300200
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.36416/1806-3756/e20190223
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Pneumologia e Tisiologia
publisher.none.fl_str_mv Sociedade Brasileira de Pneumologia e Tisiologia
dc.source.none.fl_str_mv Jornal Brasileiro de Pneumologia v.46 n.3 2020
reponame:Jornal Brasileiro de Pneumologia (Online)
instname:Sociedade Brasileira de Pneumologia e Tisiologia (SBPT)
instacron:SBPT
instname_str Sociedade Brasileira de Pneumologia e Tisiologia (SBPT)
instacron_str SBPT
institution SBPT
reponame_str Jornal Brasileiro de Pneumologia (Online)
collection Jornal Brasileiro de Pneumologia (Online)
repository.name.fl_str_mv Jornal Brasileiro de Pneumologia (Online) - Sociedade Brasileira de Pneumologia e Tisiologia (SBPT)
repository.mail.fl_str_mv ||jbp@jbp.org.br|| jpneumo@jornaldepneumologia.com.br
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