Symptom variability over the course of the day in patients with stable COPD in Brazil: a real-world observational study
Autor(a) principal: | |
---|---|
Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Jornal Brasileiro de Pneumologia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132020000300200 |
Resumo: | ABSTRACT Objective: To analyze symptoms at different times of day in patients with COPD. Methods: This was a multicenter, cross-sectional observational study conducted at eight centers in Brazil. We evaluated morning, daytime, and nighttime symptoms in patients with stable COPD. Results: We included 593 patients under regular treatment, of whom 309 (52.1%) were male and 92 (15.5%) were active smokers. The mean age was 67.7 years, and the mean FEV1 was 49.4% of the predicted value. In comparison with the patients who had mild or moderate symptoms, the 183 (30.8%) with severe symptoms were less physically active (p = 0.002), had greater airflow limitation (p < 0.001), had more outpatient exacerbations (p = 0.002) and more inpatient exacerbations (p = 0.043), as well as scoring worse on specific instruments. The most common morning and nighttime symptoms were dyspnea (in 45.2% and 33.1%, respectively), cough (in 37.5% and 33.3%, respectively), and wheezing (in 24.4% and 27.0%, respectively). The intensity of daytime symptoms correlated strongly with that of morning symptoms (r = 0.65, p < 0.001) and that of nighttime symptoms (r = 0.60, p < 0.001), as well as with the COPD Assessment Test score (r = 0.62; p < 0.001), although it showed only a weak correlation with FEV1 (r = −0.205; p < 0.001). Conclusions: Dyspnea was more common in the morning than at night. Having morning or nighttime symptoms was associated with greater daytime symptom severity. Symptom intensity was strongly associated with poor quality of life and with the frequency of exacerbations, although it was weakly associated with airflow limitation. |
id |
SBPT-1_054468923ef9158dd321a6808fc6f942 |
---|---|
oai_identifier_str |
oai:scielo:S1806-37132020000300200 |
network_acronym_str |
SBPT-1 |
network_name_str |
Jornal Brasileiro de Pneumologia (Online) |
repository_id_str |
|
spelling |
Symptom variability over the course of the day in patients with stable COPD in Brazil: a real-world observational studyPulmonary disease, chronic obstructiveSigns and symptoms, respiratoryQuality of lifeDisease progressionBrazilABSTRACT Objective: To analyze symptoms at different times of day in patients with COPD. Methods: This was a multicenter, cross-sectional observational study conducted at eight centers in Brazil. We evaluated morning, daytime, and nighttime symptoms in patients with stable COPD. Results: We included 593 patients under regular treatment, of whom 309 (52.1%) were male and 92 (15.5%) were active smokers. The mean age was 67.7 years, and the mean FEV1 was 49.4% of the predicted value. In comparison with the patients who had mild or moderate symptoms, the 183 (30.8%) with severe symptoms were less physically active (p = 0.002), had greater airflow limitation (p < 0.001), had more outpatient exacerbations (p = 0.002) and more inpatient exacerbations (p = 0.043), as well as scoring worse on specific instruments. The most common morning and nighttime symptoms were dyspnea (in 45.2% and 33.1%, respectively), cough (in 37.5% and 33.3%, respectively), and wheezing (in 24.4% and 27.0%, respectively). The intensity of daytime symptoms correlated strongly with that of morning symptoms (r = 0.65, p < 0.001) and that of nighttime symptoms (r = 0.60, p < 0.001), as well as with the COPD Assessment Test score (r = 0.62; p < 0.001), although it showed only a weak correlation with FEV1 (r = −0.205; p < 0.001). Conclusions: Dyspnea was more common in the morning than at night. Having morning or nighttime symptoms was associated with greater daytime symptom severity. Symptom intensity was strongly associated with poor quality of life and with the frequency of exacerbations, although it was weakly associated with airflow limitation.Sociedade Brasileira de Pneumologia e Tisiologia2020-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132020000300200Jornal Brasileiro de Pneumologia v.46 n.3 2020reponame:Jornal Brasileiro de Pneumologia (Online)instname:Sociedade Brasileira de Pneumologia e Tisiologia (SBPT)instacron:SBPT10.36416/1806-3756/e20190223info:eu-repo/semantics/openAccessCukier,AlbertoGodoy,Irma deCosta,Claudia Henrique daRubin,Adalberto SperbGregorio,Marcelo GervillaAlbuquerque Neto,Aldo Agra deLima,Marina AndradePereira,Monica CorsoTanni,Suzana EricoAthanazio,Rodrigo AbensurBessa,Elizabeth Jauhar CardosoWehrmeister,Fernando CesarLourenco,Cristina BassiMenezes,Ana Maria Baptistaeng2019-12-17T00:00:00Zoai:scielo:S1806-37132020000300200Revistahttp://www.jornaldepneumologia.com.br/default.aspONGhttps://old.scielo.br/oai/scielo-oai.php||jbp@jbp.org.br|| jpneumo@jornaldepneumologia.com.br1806-37561806-3713opendoar:2019-12-17T00:00Jornal Brasileiro de Pneumologia (Online) - Sociedade Brasileira de Pneumologia e Tisiologia (SBPT)false |
dc.title.none.fl_str_mv |
Symptom variability over the course of the day in patients with stable COPD in Brazil: a real-world observational study |
title |
Symptom variability over the course of the day in patients with stable COPD in Brazil: a real-world observational study |
spellingShingle |
Symptom variability over the course of the day in patients with stable COPD in Brazil: a real-world observational study Cukier,Alberto Pulmonary disease, chronic obstructive Signs and symptoms, respiratory Quality of life Disease progression Brazil |
title_short |
Symptom variability over the course of the day in patients with stable COPD in Brazil: a real-world observational study |
title_full |
Symptom variability over the course of the day in patients with stable COPD in Brazil: a real-world observational study |
title_fullStr |
Symptom variability over the course of the day in patients with stable COPD in Brazil: a real-world observational study |
title_full_unstemmed |
Symptom variability over the course of the day in patients with stable COPD in Brazil: a real-world observational study |
title_sort |
Symptom variability over the course of the day in patients with stable COPD in Brazil: a real-world observational study |
author |
Cukier,Alberto |
author_facet |
Cukier,Alberto Godoy,Irma de Costa,Claudia Henrique da Rubin,Adalberto Sperb Gregorio,Marcelo Gervilla Albuquerque Neto,Aldo Agra de Lima,Marina Andrade Pereira,Monica Corso Tanni,Suzana Erico Athanazio,Rodrigo Abensur Bessa,Elizabeth Jauhar Cardoso Wehrmeister,Fernando Cesar Lourenco,Cristina Bassi Menezes,Ana Maria Baptista |
author_role |
author |
author2 |
Godoy,Irma de Costa,Claudia Henrique da Rubin,Adalberto Sperb Gregorio,Marcelo Gervilla Albuquerque Neto,Aldo Agra de Lima,Marina Andrade Pereira,Monica Corso Tanni,Suzana Erico Athanazio,Rodrigo Abensur Bessa,Elizabeth Jauhar Cardoso Wehrmeister,Fernando Cesar Lourenco,Cristina Bassi Menezes,Ana Maria Baptista |
author2_role |
author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Cukier,Alberto Godoy,Irma de Costa,Claudia Henrique da Rubin,Adalberto Sperb Gregorio,Marcelo Gervilla Albuquerque Neto,Aldo Agra de Lima,Marina Andrade Pereira,Monica Corso Tanni,Suzana Erico Athanazio,Rodrigo Abensur Bessa,Elizabeth Jauhar Cardoso Wehrmeister,Fernando Cesar Lourenco,Cristina Bassi Menezes,Ana Maria Baptista |
dc.subject.por.fl_str_mv |
Pulmonary disease, chronic obstructive Signs and symptoms, respiratory Quality of life Disease progression Brazil |
topic |
Pulmonary disease, chronic obstructive Signs and symptoms, respiratory Quality of life Disease progression Brazil |
description |
ABSTRACT Objective: To analyze symptoms at different times of day in patients with COPD. Methods: This was a multicenter, cross-sectional observational study conducted at eight centers in Brazil. We evaluated morning, daytime, and nighttime symptoms in patients with stable COPD. Results: We included 593 patients under regular treatment, of whom 309 (52.1%) were male and 92 (15.5%) were active smokers. The mean age was 67.7 years, and the mean FEV1 was 49.4% of the predicted value. In comparison with the patients who had mild or moderate symptoms, the 183 (30.8%) with severe symptoms were less physically active (p = 0.002), had greater airflow limitation (p < 0.001), had more outpatient exacerbations (p = 0.002) and more inpatient exacerbations (p = 0.043), as well as scoring worse on specific instruments. The most common morning and nighttime symptoms were dyspnea (in 45.2% and 33.1%, respectively), cough (in 37.5% and 33.3%, respectively), and wheezing (in 24.4% and 27.0%, respectively). The intensity of daytime symptoms correlated strongly with that of morning symptoms (r = 0.65, p < 0.001) and that of nighttime symptoms (r = 0.60, p < 0.001), as well as with the COPD Assessment Test score (r = 0.62; p < 0.001), although it showed only a weak correlation with FEV1 (r = −0.205; p < 0.001). Conclusions: Dyspnea was more common in the morning than at night. Having morning or nighttime symptoms was associated with greater daytime symptom severity. Symptom intensity was strongly associated with poor quality of life and with the frequency of exacerbations, although it was weakly associated with airflow limitation. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132020000300200 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132020000300200 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.36416/1806-3756/e20190223 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Pneumologia e Tisiologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Pneumologia e Tisiologia |
dc.source.none.fl_str_mv |
Jornal Brasileiro de Pneumologia v.46 n.3 2020 reponame:Jornal Brasileiro de Pneumologia (Online) instname:Sociedade Brasileira de Pneumologia e Tisiologia (SBPT) instacron:SBPT |
instname_str |
Sociedade Brasileira de Pneumologia e Tisiologia (SBPT) |
instacron_str |
SBPT |
institution |
SBPT |
reponame_str |
Jornal Brasileiro de Pneumologia (Online) |
collection |
Jornal Brasileiro de Pneumologia (Online) |
repository.name.fl_str_mv |
Jornal Brasileiro de Pneumologia (Online) - Sociedade Brasileira de Pneumologia e Tisiologia (SBPT) |
repository.mail.fl_str_mv |
||jbp@jbp.org.br|| jpneumo@jornaldepneumologia.com.br |
_version_ |
1750318347751260160 |