Functional improvement in patients with idiopathic pulmonary fibrosis undergoing single lung transplantation

Detalhes bibliográficos
Autor(a) principal: Rubin,Adalberto Sperb
Data de Publicação: 2015
Outros Autores: Nascimento,Douglas Zaione, Sanchez,Letícia, Watte,Guilherme, Holand,Arthur Rodrigo Ronconi, Fassbind,Derrick Alexandre, Camargo,José Jesus
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Jornal Brasileiro de Pneumologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132015000400299
Resumo: AbstractObjective: To evaluate the changes in lung function in the first year after single lung transplantation in patients with idiopathic pulmonary fibrosis (IPF).Methods: We retrospectively evaluated patients with IPF who underwent single lung transplantation between January of 2006 and December of 2012, reviewing the changes in the lung function occurring during the first year after the procedure.Results: Of the 218 patients undergoing lung transplantation during the study period, 79 (36.2%) had IPF. Of those 79 patients, 24 (30%) died, and 11 (14%) did not undergo spirometry at the end of the first year. Of the 44 patients included in the study, 29 (66%) were men. The mean age of the patients was 57 years. Before transplantation, mean FVC, FEV1, and FEV1/FVC ratio were 1.78 L (50% of predicted), 1.48 L (52% of predicted), and 83%, respectively. In the first month after transplantation, there was a mean increase of 12% in FVC (400 mL) and FEV1 (350 mL). In the third month after transplantation, there were additional increases, of 5% (170 mL) in FVC and 1% (50 mL) in FEV1. At the end of the first year, the functional improvement persisted, with a mean gain of 19% (620 mL) in FVC and 16% (430 mL) in FEV1.Conclusions: Single lung transplantation in IPF patients who survive for at least one year provides significant and progressive benefits in lung function during the first year. This procedure is an important therapeutic alternative in the management of IPF.
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spelling Functional improvement in patients with idiopathic pulmonary fibrosis undergoing single lung transplantationPulmonary fibrosisRespiratory function testsLung transplantationAbstractObjective: To evaluate the changes in lung function in the first year after single lung transplantation in patients with idiopathic pulmonary fibrosis (IPF).Methods: We retrospectively evaluated patients with IPF who underwent single lung transplantation between January of 2006 and December of 2012, reviewing the changes in the lung function occurring during the first year after the procedure.Results: Of the 218 patients undergoing lung transplantation during the study period, 79 (36.2%) had IPF. Of those 79 patients, 24 (30%) died, and 11 (14%) did not undergo spirometry at the end of the first year. Of the 44 patients included in the study, 29 (66%) were men. The mean age of the patients was 57 years. Before transplantation, mean FVC, FEV1, and FEV1/FVC ratio were 1.78 L (50% of predicted), 1.48 L (52% of predicted), and 83%, respectively. In the first month after transplantation, there was a mean increase of 12% in FVC (400 mL) and FEV1 (350 mL). In the third month after transplantation, there were additional increases, of 5% (170 mL) in FVC and 1% (50 mL) in FEV1. At the end of the first year, the functional improvement persisted, with a mean gain of 19% (620 mL) in FVC and 16% (430 mL) in FEV1.Conclusions: Single lung transplantation in IPF patients who survive for at least one year provides significant and progressive benefits in lung function during the first year. This procedure is an important therapeutic alternative in the management of IPF.Sociedade Brasileira de Pneumologia e Tisiologia2015-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132015000400299Jornal Brasileiro de Pneumologia v.41 n.4 2015reponame:Jornal Brasileiro de Pneumologia (Online)instname:Sociedade Brasileira de Pneumologia e Tisiologia (SBPT)instacron:SBPT10.1590/S1806-37132015000000057info:eu-repo/semantics/openAccessRubin,Adalberto SperbNascimento,Douglas ZaioneSanchez,LetíciaWatte,GuilhermeHoland,Arthur Rodrigo RonconiFassbind,Derrick AlexandreCamargo,José Jesuseng2015-09-14T00:00:00Zoai:scielo:S1806-37132015000400299Revistahttp://www.jornaldepneumologia.com.br/default.aspONGhttps://old.scielo.br/oai/scielo-oai.php||jbp@jbp.org.br|| jpneumo@jornaldepneumologia.com.br1806-37561806-3713opendoar:2015-09-14T00:00Jornal Brasileiro de Pneumologia (Online) - Sociedade Brasileira de Pneumologia e Tisiologia (SBPT)false
dc.title.none.fl_str_mv Functional improvement in patients with idiopathic pulmonary fibrosis undergoing single lung transplantation
title Functional improvement in patients with idiopathic pulmonary fibrosis undergoing single lung transplantation
spellingShingle Functional improvement in patients with idiopathic pulmonary fibrosis undergoing single lung transplantation
Rubin,Adalberto Sperb
Pulmonary fibrosis
Respiratory function tests
Lung transplantation
title_short Functional improvement in patients with idiopathic pulmonary fibrosis undergoing single lung transplantation
title_full Functional improvement in patients with idiopathic pulmonary fibrosis undergoing single lung transplantation
title_fullStr Functional improvement in patients with idiopathic pulmonary fibrosis undergoing single lung transplantation
title_full_unstemmed Functional improvement in patients with idiopathic pulmonary fibrosis undergoing single lung transplantation
title_sort Functional improvement in patients with idiopathic pulmonary fibrosis undergoing single lung transplantation
author Rubin,Adalberto Sperb
author_facet Rubin,Adalberto Sperb
Nascimento,Douglas Zaione
Sanchez,Letícia
Watte,Guilherme
Holand,Arthur Rodrigo Ronconi
Fassbind,Derrick Alexandre
Camargo,José Jesus
author_role author
author2 Nascimento,Douglas Zaione
Sanchez,Letícia
Watte,Guilherme
Holand,Arthur Rodrigo Ronconi
Fassbind,Derrick Alexandre
Camargo,José Jesus
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Rubin,Adalberto Sperb
Nascimento,Douglas Zaione
Sanchez,Letícia
Watte,Guilherme
Holand,Arthur Rodrigo Ronconi
Fassbind,Derrick Alexandre
Camargo,José Jesus
dc.subject.por.fl_str_mv Pulmonary fibrosis
Respiratory function tests
Lung transplantation
topic Pulmonary fibrosis
Respiratory function tests
Lung transplantation
description AbstractObjective: To evaluate the changes in lung function in the first year after single lung transplantation in patients with idiopathic pulmonary fibrosis (IPF).Methods: We retrospectively evaluated patients with IPF who underwent single lung transplantation between January of 2006 and December of 2012, reviewing the changes in the lung function occurring during the first year after the procedure.Results: Of the 218 patients undergoing lung transplantation during the study period, 79 (36.2%) had IPF. Of those 79 patients, 24 (30%) died, and 11 (14%) did not undergo spirometry at the end of the first year. Of the 44 patients included in the study, 29 (66%) were men. The mean age of the patients was 57 years. Before transplantation, mean FVC, FEV1, and FEV1/FVC ratio were 1.78 L (50% of predicted), 1.48 L (52% of predicted), and 83%, respectively. In the first month after transplantation, there was a mean increase of 12% in FVC (400 mL) and FEV1 (350 mL). In the third month after transplantation, there were additional increases, of 5% (170 mL) in FVC and 1% (50 mL) in FEV1. At the end of the first year, the functional improvement persisted, with a mean gain of 19% (620 mL) in FVC and 16% (430 mL) in FEV1.Conclusions: Single lung transplantation in IPF patients who survive for at least one year provides significant and progressive benefits in lung function during the first year. This procedure is an important therapeutic alternative in the management of IPF.
publishDate 2015
dc.date.none.fl_str_mv 2015-08-01
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dc.language.iso.fl_str_mv eng
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dc.relation.none.fl_str_mv 10.1590/S1806-37132015000000057
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dc.publisher.none.fl_str_mv Sociedade Brasileira de Pneumologia e Tisiologia
publisher.none.fl_str_mv Sociedade Brasileira de Pneumologia e Tisiologia
dc.source.none.fl_str_mv Jornal Brasileiro de Pneumologia v.41 n.4 2015
reponame:Jornal Brasileiro de Pneumologia (Online)
instname:Sociedade Brasileira de Pneumologia e Tisiologia (SBPT)
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