Bronchial carcinoid tumors: second primary neoplasms and outcomes of surgical treatment
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Jornal Brasileiro de Pneumologia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132019000500206 |
Resumo: | ABSTRACT Objective: To analyze determinants of prognosis in patients with bronchial carcinoid tumors treated surgically and the potential concomitance of such tumors with second primary neoplasms. Methods: This was a retrospective analysis of 51 bronchial carcinoid tumors treated surgically between 2007 and 2016. Disease-free survival (DFS) was calculated by the Kaplan-Meier method, and determinants of prognosis were evaluated. Primary neoplasms that were concomitant with the bronchial carcinoid tumors were identified by reviewing patient charts. Results: The median age was 51.2 years, 58.8% of the patients were female, and 52.9% were asymptomatic. The most common histology was typical carcinoid (in 80.4%). Five-year DFS was 89.8%. Ki-67 expression was determined in 27 patients, and five-year DFS was better among the patients in whom Ki-67 expression was ≤ 5% than among those in whom it was > 5% (100% vs. 47.6%; p = 0.01). Concomitant primary neoplasms were observed in 14 (27.4%) of the 51 cases. Among the concomitant primary neoplasms that were malignant, the most common was lung adenocarcinoma, which was observed in 3 cases. Concomitant primary neoplasms were more common in patients who were asymptomatic and in those with small tumors. Conclusions: Surgical resection is the mainstay treatment of bronchopulmonary carcinoid tumors and confers a good prognosis. Bronchial carcinoid tumors are likely to be accompanied by second primary neoplasms. |
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Bronchial carcinoid tumors: second primary neoplasms and outcomes of surgical treatmentCarcinoid tumor/diagnosisCarcinoid tumor/surgeryNeoplasms, second primaryLung neoplasmsABSTRACT Objective: To analyze determinants of prognosis in patients with bronchial carcinoid tumors treated surgically and the potential concomitance of such tumors with second primary neoplasms. Methods: This was a retrospective analysis of 51 bronchial carcinoid tumors treated surgically between 2007 and 2016. Disease-free survival (DFS) was calculated by the Kaplan-Meier method, and determinants of prognosis were evaluated. Primary neoplasms that were concomitant with the bronchial carcinoid tumors were identified by reviewing patient charts. Results: The median age was 51.2 years, 58.8% of the patients were female, and 52.9% were asymptomatic. The most common histology was typical carcinoid (in 80.4%). Five-year DFS was 89.8%. Ki-67 expression was determined in 27 patients, and five-year DFS was better among the patients in whom Ki-67 expression was ≤ 5% than among those in whom it was > 5% (100% vs. 47.6%; p = 0.01). Concomitant primary neoplasms were observed in 14 (27.4%) of the 51 cases. Among the concomitant primary neoplasms that were malignant, the most common was lung adenocarcinoma, which was observed in 3 cases. Concomitant primary neoplasms were more common in patients who were asymptomatic and in those with small tumors. Conclusions: Surgical resection is the mainstay treatment of bronchopulmonary carcinoid tumors and confers a good prognosis. Bronchial carcinoid tumors are likely to be accompanied by second primary neoplasms.Sociedade Brasileira de Pneumologia e Tisiologia2019-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132019000500206Jornal Brasileiro de Pneumologia v.45 n.5 2019reponame:Jornal Brasileiro de Pneumologia (Online)instname:Sociedade Brasileira de Pneumologia e Tisiologia (SBPT)instacron:SBPT10.1590/1806-3713/e20180140info:eu-repo/semantics/openAccessGross,Jefferson LuizVega,Marcel Adalid TapiaFrenhi,Guilherme StrambiTorres,Silvio MeloCampos,Antonio Hugo José Froes MarquesPinto,Clovis Antonio LopesCosta,Felipe D’AlmeidaHaddad,Fabio Joséeng2019-09-13T00:00:00Zoai:scielo:S1806-37132019000500206Revistahttp://www.jornaldepneumologia.com.br/default.aspONGhttps://old.scielo.br/oai/scielo-oai.php||jbp@jbp.org.br|| jpneumo@jornaldepneumologia.com.br1806-37561806-3713opendoar:2019-09-13T00:00Jornal Brasileiro de Pneumologia (Online) - Sociedade Brasileira de Pneumologia e Tisiologia (SBPT)false |
dc.title.none.fl_str_mv |
Bronchial carcinoid tumors: second primary neoplasms and outcomes of surgical treatment |
title |
Bronchial carcinoid tumors: second primary neoplasms and outcomes of surgical treatment |
spellingShingle |
Bronchial carcinoid tumors: second primary neoplasms and outcomes of surgical treatment Gross,Jefferson Luiz Carcinoid tumor/diagnosis Carcinoid tumor/surgery Neoplasms, second primary Lung neoplasms |
title_short |
Bronchial carcinoid tumors: second primary neoplasms and outcomes of surgical treatment |
title_full |
Bronchial carcinoid tumors: second primary neoplasms and outcomes of surgical treatment |
title_fullStr |
Bronchial carcinoid tumors: second primary neoplasms and outcomes of surgical treatment |
title_full_unstemmed |
Bronchial carcinoid tumors: second primary neoplasms and outcomes of surgical treatment |
title_sort |
Bronchial carcinoid tumors: second primary neoplasms and outcomes of surgical treatment |
author |
Gross,Jefferson Luiz |
author_facet |
Gross,Jefferson Luiz Vega,Marcel Adalid Tapia Frenhi,Guilherme Strambi Torres,Silvio Melo Campos,Antonio Hugo José Froes Marques Pinto,Clovis Antonio Lopes Costa,Felipe D’Almeida Haddad,Fabio José |
author_role |
author |
author2 |
Vega,Marcel Adalid Tapia Frenhi,Guilherme Strambi Torres,Silvio Melo Campos,Antonio Hugo José Froes Marques Pinto,Clovis Antonio Lopes Costa,Felipe D’Almeida Haddad,Fabio José |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Gross,Jefferson Luiz Vega,Marcel Adalid Tapia Frenhi,Guilherme Strambi Torres,Silvio Melo Campos,Antonio Hugo José Froes Marques Pinto,Clovis Antonio Lopes Costa,Felipe D’Almeida Haddad,Fabio José |
dc.subject.por.fl_str_mv |
Carcinoid tumor/diagnosis Carcinoid tumor/surgery Neoplasms, second primary Lung neoplasms |
topic |
Carcinoid tumor/diagnosis Carcinoid tumor/surgery Neoplasms, second primary Lung neoplasms |
description |
ABSTRACT Objective: To analyze determinants of prognosis in patients with bronchial carcinoid tumors treated surgically and the potential concomitance of such tumors with second primary neoplasms. Methods: This was a retrospective analysis of 51 bronchial carcinoid tumors treated surgically between 2007 and 2016. Disease-free survival (DFS) was calculated by the Kaplan-Meier method, and determinants of prognosis were evaluated. Primary neoplasms that were concomitant with the bronchial carcinoid tumors were identified by reviewing patient charts. Results: The median age was 51.2 years, 58.8% of the patients were female, and 52.9% were asymptomatic. The most common histology was typical carcinoid (in 80.4%). Five-year DFS was 89.8%. Ki-67 expression was determined in 27 patients, and five-year DFS was better among the patients in whom Ki-67 expression was ≤ 5% than among those in whom it was > 5% (100% vs. 47.6%; p = 0.01). Concomitant primary neoplasms were observed in 14 (27.4%) of the 51 cases. Among the concomitant primary neoplasms that were malignant, the most common was lung adenocarcinoma, which was observed in 3 cases. Concomitant primary neoplasms were more common in patients who were asymptomatic and in those with small tumors. Conclusions: Surgical resection is the mainstay treatment of bronchopulmonary carcinoid tumors and confers a good prognosis. Bronchial carcinoid tumors are likely to be accompanied by second primary neoplasms. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132019000500206 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132019000500206 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1806-3713/e20180140 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Pneumologia e Tisiologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Pneumologia e Tisiologia |
dc.source.none.fl_str_mv |
Jornal Brasileiro de Pneumologia v.45 n.5 2019 reponame:Jornal Brasileiro de Pneumologia (Online) instname:Sociedade Brasileira de Pneumologia e Tisiologia (SBPT) instacron:SBPT |
instname_str |
Sociedade Brasileira de Pneumologia e Tisiologia (SBPT) |
instacron_str |
SBPT |
institution |
SBPT |
reponame_str |
Jornal Brasileiro de Pneumologia (Online) |
collection |
Jornal Brasileiro de Pneumologia (Online) |
repository.name.fl_str_mv |
Jornal Brasileiro de Pneumologia (Online) - Sociedade Brasileira de Pneumologia e Tisiologia (SBPT) |
repository.mail.fl_str_mv |
||jbp@jbp.org.br|| jpneumo@jornaldepneumologia.com.br |
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1750318347674714112 |