Bronchial carcinoid tumors: second primary neoplasms and outcomes of surgical treatment

Detalhes bibliográficos
Autor(a) principal: Gross,Jefferson Luiz
Data de Publicação: 2019
Outros Autores: Vega,Marcel Adalid Tapia, Frenhi,Guilherme Strambi, Torres,Silvio Melo, Campos,Antonio Hugo José Froes Marques, Pinto,Clovis Antonio Lopes, Costa,Felipe D’Almeida, Haddad,Fabio José
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Jornal Brasileiro de Pneumologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132019000500206
Resumo: ABSTRACT Objective: To analyze determinants of prognosis in patients with bronchial carcinoid tumors treated surgically and the potential concomitance of such tumors with second primary neoplasms. Methods: This was a retrospective analysis of 51 bronchial carcinoid tumors treated surgically between 2007 and 2016. Disease-free survival (DFS) was calculated by the Kaplan-Meier method, and determinants of prognosis were evaluated. Primary neoplasms that were concomitant with the bronchial carcinoid tumors were identified by reviewing patient charts. Results: The median age was 51.2 years, 58.8% of the patients were female, and 52.9% were asymptomatic. The most common histology was typical carcinoid (in 80.4%). Five-year DFS was 89.8%. Ki-67 expression was determined in 27 patients, and five-year DFS was better among the patients in whom Ki-67 expression was ≤ 5% than among those in whom it was > 5% (100% vs. 47.6%; p = 0.01). Concomitant primary neoplasms were observed in 14 (27.4%) of the 51 cases. Among the concomitant primary neoplasms that were malignant, the most common was lung adenocarcinoma, which was observed in 3 cases. Concomitant primary neoplasms were more common in patients who were asymptomatic and in those with small tumors. Conclusions: Surgical resection is the mainstay treatment of bronchopulmonary carcinoid tumors and confers a good prognosis. Bronchial carcinoid tumors are likely to be accompanied by second primary neoplasms.
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spelling Bronchial carcinoid tumors: second primary neoplasms and outcomes of surgical treatmentCarcinoid tumor/diagnosisCarcinoid tumor/surgeryNeoplasms, second primaryLung neoplasmsABSTRACT Objective: To analyze determinants of prognosis in patients with bronchial carcinoid tumors treated surgically and the potential concomitance of such tumors with second primary neoplasms. Methods: This was a retrospective analysis of 51 bronchial carcinoid tumors treated surgically between 2007 and 2016. Disease-free survival (DFS) was calculated by the Kaplan-Meier method, and determinants of prognosis were evaluated. Primary neoplasms that were concomitant with the bronchial carcinoid tumors were identified by reviewing patient charts. Results: The median age was 51.2 years, 58.8% of the patients were female, and 52.9% were asymptomatic. The most common histology was typical carcinoid (in 80.4%). Five-year DFS was 89.8%. Ki-67 expression was determined in 27 patients, and five-year DFS was better among the patients in whom Ki-67 expression was ≤ 5% than among those in whom it was > 5% (100% vs. 47.6%; p = 0.01). Concomitant primary neoplasms were observed in 14 (27.4%) of the 51 cases. Among the concomitant primary neoplasms that were malignant, the most common was lung adenocarcinoma, which was observed in 3 cases. Concomitant primary neoplasms were more common in patients who were asymptomatic and in those with small tumors. Conclusions: Surgical resection is the mainstay treatment of bronchopulmonary carcinoid tumors and confers a good prognosis. Bronchial carcinoid tumors are likely to be accompanied by second primary neoplasms.Sociedade Brasileira de Pneumologia e Tisiologia2019-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132019000500206Jornal Brasileiro de Pneumologia v.45 n.5 2019reponame:Jornal Brasileiro de Pneumologia (Online)instname:Sociedade Brasileira de Pneumologia e Tisiologia (SBPT)instacron:SBPT10.1590/1806-3713/e20180140info:eu-repo/semantics/openAccessGross,Jefferson LuizVega,Marcel Adalid TapiaFrenhi,Guilherme StrambiTorres,Silvio MeloCampos,Antonio Hugo José Froes MarquesPinto,Clovis Antonio LopesCosta,Felipe D’AlmeidaHaddad,Fabio Joséeng2019-09-13T00:00:00Zoai:scielo:S1806-37132019000500206Revistahttp://www.jornaldepneumologia.com.br/default.aspONGhttps://old.scielo.br/oai/scielo-oai.php||jbp@jbp.org.br|| jpneumo@jornaldepneumologia.com.br1806-37561806-3713opendoar:2019-09-13T00:00Jornal Brasileiro de Pneumologia (Online) - Sociedade Brasileira de Pneumologia e Tisiologia (SBPT)false
dc.title.none.fl_str_mv Bronchial carcinoid tumors: second primary neoplasms and outcomes of surgical treatment
title Bronchial carcinoid tumors: second primary neoplasms and outcomes of surgical treatment
spellingShingle Bronchial carcinoid tumors: second primary neoplasms and outcomes of surgical treatment
Gross,Jefferson Luiz
Carcinoid tumor/diagnosis
Carcinoid tumor/surgery
Neoplasms, second primary
Lung neoplasms
title_short Bronchial carcinoid tumors: second primary neoplasms and outcomes of surgical treatment
title_full Bronchial carcinoid tumors: second primary neoplasms and outcomes of surgical treatment
title_fullStr Bronchial carcinoid tumors: second primary neoplasms and outcomes of surgical treatment
title_full_unstemmed Bronchial carcinoid tumors: second primary neoplasms and outcomes of surgical treatment
title_sort Bronchial carcinoid tumors: second primary neoplasms and outcomes of surgical treatment
author Gross,Jefferson Luiz
author_facet Gross,Jefferson Luiz
Vega,Marcel Adalid Tapia
Frenhi,Guilherme Strambi
Torres,Silvio Melo
Campos,Antonio Hugo José Froes Marques
Pinto,Clovis Antonio Lopes
Costa,Felipe D’Almeida
Haddad,Fabio José
author_role author
author2 Vega,Marcel Adalid Tapia
Frenhi,Guilherme Strambi
Torres,Silvio Melo
Campos,Antonio Hugo José Froes Marques
Pinto,Clovis Antonio Lopes
Costa,Felipe D’Almeida
Haddad,Fabio José
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Gross,Jefferson Luiz
Vega,Marcel Adalid Tapia
Frenhi,Guilherme Strambi
Torres,Silvio Melo
Campos,Antonio Hugo José Froes Marques
Pinto,Clovis Antonio Lopes
Costa,Felipe D’Almeida
Haddad,Fabio José
dc.subject.por.fl_str_mv Carcinoid tumor/diagnosis
Carcinoid tumor/surgery
Neoplasms, second primary
Lung neoplasms
topic Carcinoid tumor/diagnosis
Carcinoid tumor/surgery
Neoplasms, second primary
Lung neoplasms
description ABSTRACT Objective: To analyze determinants of prognosis in patients with bronchial carcinoid tumors treated surgically and the potential concomitance of such tumors with second primary neoplasms. Methods: This was a retrospective analysis of 51 bronchial carcinoid tumors treated surgically between 2007 and 2016. Disease-free survival (DFS) was calculated by the Kaplan-Meier method, and determinants of prognosis were evaluated. Primary neoplasms that were concomitant with the bronchial carcinoid tumors were identified by reviewing patient charts. Results: The median age was 51.2 years, 58.8% of the patients were female, and 52.9% were asymptomatic. The most common histology was typical carcinoid (in 80.4%). Five-year DFS was 89.8%. Ki-67 expression was determined in 27 patients, and five-year DFS was better among the patients in whom Ki-67 expression was ≤ 5% than among those in whom it was > 5% (100% vs. 47.6%; p = 0.01). Concomitant primary neoplasms were observed in 14 (27.4%) of the 51 cases. Among the concomitant primary neoplasms that were malignant, the most common was lung adenocarcinoma, which was observed in 3 cases. Concomitant primary neoplasms were more common in patients who were asymptomatic and in those with small tumors. Conclusions: Surgical resection is the mainstay treatment of bronchopulmonary carcinoid tumors and confers a good prognosis. Bronchial carcinoid tumors are likely to be accompanied by second primary neoplasms.
publishDate 2019
dc.date.none.fl_str_mv 2019-01-01
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dc.language.iso.fl_str_mv eng
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dc.publisher.none.fl_str_mv Sociedade Brasileira de Pneumologia e Tisiologia
publisher.none.fl_str_mv Sociedade Brasileira de Pneumologia e Tisiologia
dc.source.none.fl_str_mv Jornal Brasileiro de Pneumologia v.45 n.5 2019
reponame:Jornal Brasileiro de Pneumologia (Online)
instname:Sociedade Brasileira de Pneumologia e Tisiologia (SBPT)
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reponame_str Jornal Brasileiro de Pneumologia (Online)
collection Jornal Brasileiro de Pneumologia (Online)
repository.name.fl_str_mv Jornal Brasileiro de Pneumologia (Online) - Sociedade Brasileira de Pneumologia e Tisiologia (SBPT)
repository.mail.fl_str_mv ||jbp@jbp.org.br|| jpneumo@jornaldepneumologia.com.br
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