Simultaneous determination of paracetamol and ibuprofen in pharmaceutical samples by differential pulse voltammetry using a boron-doped diamond electrode
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of the Brazilian Chemical Society (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532014000300010 |
Resumo: | This work presents a simple, fast and low-cost methodology for the simultaneous determination of paracetamol (PC) and ibuprofen (IB) in pharmaceutical formulations by differential pulse voltammetry using a boron-doped diamond (BDD) electrode. A well-defined oxidation peak was observed using the BDD electrode for each analyte (0.85 V for PC and 1.72 V for IB (vs. Ag/AgCl)) in 0.1 mol L-1 H2SO4 solution containing 10% (v/v) of ethanol. Calibration curves for the simultaneous determination of PC and IB showed a linear response for both drugs in a concentration range of 20 to 400 µmol L-1 (r² = 0.999), with a detection limit of 7.1 µmol L-1 for PC and 3.8 µmol L-1 for IB. The addition-recovery studies in samples were about 100% and the results were validated by chromatographic methods. |
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Simultaneous determination of paracetamol and ibuprofen in pharmaceutical samples by differential pulse voltammetry using a boron-doped diamond electrodesimultaneous analysisdifferential pulse voltammetryibuprofenparacetamolThis work presents a simple, fast and low-cost methodology for the simultaneous determination of paracetamol (PC) and ibuprofen (IB) in pharmaceutical formulations by differential pulse voltammetry using a boron-doped diamond (BDD) electrode. A well-defined oxidation peak was observed using the BDD electrode for each analyte (0.85 V for PC and 1.72 V for IB (vs. Ag/AgCl)) in 0.1 mol L-1 H2SO4 solution containing 10% (v/v) of ethanol. Calibration curves for the simultaneous determination of PC and IB showed a linear response for both drugs in a concentration range of 20 to 400 µmol L-1 (r² = 0.999), with a detection limit of 7.1 µmol L-1 for PC and 3.8 µmol L-1 for IB. The addition-recovery studies in samples were about 100% and the results were validated by chromatographic methods.Sociedade Brasileira de Química2014-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532014000300010Journal of the Brazilian Chemical Society v.25 n.3 2014reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.5935/0103-5053.20140005info:eu-repo/semantics/openAccessLima,Amanda B.Torres,Lívia M. F. C.Guimarães,Carlos F. R. C.Verly,Rodrigo M.Silva,Leonardo M. daCarvalho Júnior,Álvaro D.Santos,Wallans T. P. doseng2014-03-19T00:00:00Zoai:scielo:S0103-50532014000300010Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2014-03-19T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
Simultaneous determination of paracetamol and ibuprofen in pharmaceutical samples by differential pulse voltammetry using a boron-doped diamond electrode |
title |
Simultaneous determination of paracetamol and ibuprofen in pharmaceutical samples by differential pulse voltammetry using a boron-doped diamond electrode |
spellingShingle |
Simultaneous determination of paracetamol and ibuprofen in pharmaceutical samples by differential pulse voltammetry using a boron-doped diamond electrode Lima,Amanda B. simultaneous analysis differential pulse voltammetry ibuprofen paracetamol |
title_short |
Simultaneous determination of paracetamol and ibuprofen in pharmaceutical samples by differential pulse voltammetry using a boron-doped diamond electrode |
title_full |
Simultaneous determination of paracetamol and ibuprofen in pharmaceutical samples by differential pulse voltammetry using a boron-doped diamond electrode |
title_fullStr |
Simultaneous determination of paracetamol and ibuprofen in pharmaceutical samples by differential pulse voltammetry using a boron-doped diamond electrode |
title_full_unstemmed |
Simultaneous determination of paracetamol and ibuprofen in pharmaceutical samples by differential pulse voltammetry using a boron-doped diamond electrode |
title_sort |
Simultaneous determination of paracetamol and ibuprofen in pharmaceutical samples by differential pulse voltammetry using a boron-doped diamond electrode |
author |
Lima,Amanda B. |
author_facet |
Lima,Amanda B. Torres,Lívia M. F. C. Guimarães,Carlos F. R. C. Verly,Rodrigo M. Silva,Leonardo M. da Carvalho Júnior,Álvaro D. Santos,Wallans T. P. dos |
author_role |
author |
author2 |
Torres,Lívia M. F. C. Guimarães,Carlos F. R. C. Verly,Rodrigo M. Silva,Leonardo M. da Carvalho Júnior,Álvaro D. Santos,Wallans T. P. dos |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Lima,Amanda B. Torres,Lívia M. F. C. Guimarães,Carlos F. R. C. Verly,Rodrigo M. Silva,Leonardo M. da Carvalho Júnior,Álvaro D. Santos,Wallans T. P. dos |
dc.subject.por.fl_str_mv |
simultaneous analysis differential pulse voltammetry ibuprofen paracetamol |
topic |
simultaneous analysis differential pulse voltammetry ibuprofen paracetamol |
description |
This work presents a simple, fast and low-cost methodology for the simultaneous determination of paracetamol (PC) and ibuprofen (IB) in pharmaceutical formulations by differential pulse voltammetry using a boron-doped diamond (BDD) electrode. A well-defined oxidation peak was observed using the BDD electrode for each analyte (0.85 V for PC and 1.72 V for IB (vs. Ag/AgCl)) in 0.1 mol L-1 H2SO4 solution containing 10% (v/v) of ethanol. Calibration curves for the simultaneous determination of PC and IB showed a linear response for both drugs in a concentration range of 20 to 400 µmol L-1 (r² = 0.999), with a detection limit of 7.1 µmol L-1 for PC and 3.8 µmol L-1 for IB. The addition-recovery studies in samples were about 100% and the results were validated by chromatographic methods. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-03-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532014000300010 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532014000300010 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.5935/0103-5053.20140005 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Journal of the Brazilian Chemical Society v.25 n.3 2014 reponame:Journal of the Brazilian Chemical Society (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Journal of the Brazilian Chemical Society (Online) |
collection |
Journal of the Brazilian Chemical Society (Online) |
repository.name.fl_str_mv |
Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
||office@jbcs.sbq.org.br |
_version_ |
1750318175744950272 |