Simultaneous determination of paracetamol and ibuprofen in pharmaceutical samples by differential pulse voltammetry using a boron-doped diamond electrode

Detalhes bibliográficos
Autor(a) principal: Lima,Amanda B.
Data de Publicação: 2014
Outros Autores: Torres,Lívia M. F. C., Guimarães,Carlos F. R. C., Verly,Rodrigo M., Silva,Leonardo M. da, Carvalho Júnior,Álvaro D., Santos,Wallans T. P. dos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532014000300010
Resumo: This work presents a simple, fast and low-cost methodology for the simultaneous determination of paracetamol (PC) and ibuprofen (IB) in pharmaceutical formulations by differential pulse voltammetry using a boron-doped diamond (BDD) electrode. A well-defined oxidation peak was observed using the BDD electrode for each analyte (0.85 V for PC and 1.72 V for IB (vs. Ag/AgCl)) in 0.1 mol L-1 H2SO4 solution containing 10% (v/v) of ethanol. Calibration curves for the simultaneous determination of PC and IB showed a linear response for both drugs in a concentration range of 20 to 400 µmol L-1 (r² = 0.999), with a detection limit of 7.1 µmol L-1 for PC and 3.8 µmol L-1 for IB. The addition-recovery studies in samples were about 100% and the results were validated by chromatographic methods.
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spelling Simultaneous determination of paracetamol and ibuprofen in pharmaceutical samples by differential pulse voltammetry using a boron-doped diamond electrodesimultaneous analysisdifferential pulse voltammetryibuprofenparacetamolThis work presents a simple, fast and low-cost methodology for the simultaneous determination of paracetamol (PC) and ibuprofen (IB) in pharmaceutical formulations by differential pulse voltammetry using a boron-doped diamond (BDD) electrode. A well-defined oxidation peak was observed using the BDD electrode for each analyte (0.85 V for PC and 1.72 V for IB (vs. Ag/AgCl)) in 0.1 mol L-1 H2SO4 solution containing 10% (v/v) of ethanol. Calibration curves for the simultaneous determination of PC and IB showed a linear response for both drugs in a concentration range of 20 to 400 µmol L-1 (r² = 0.999), with a detection limit of 7.1 µmol L-1 for PC and 3.8 µmol L-1 for IB. The addition-recovery studies in samples were about 100% and the results were validated by chromatographic methods.Sociedade Brasileira de Química2014-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532014000300010Journal of the Brazilian Chemical Society v.25 n.3 2014reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.5935/0103-5053.20140005info:eu-repo/semantics/openAccessLima,Amanda B.Torres,Lívia M. F. C.Guimarães,Carlos F. R. C.Verly,Rodrigo M.Silva,Leonardo M. daCarvalho Júnior,Álvaro D.Santos,Wallans T. P. doseng2014-03-19T00:00:00Zoai:scielo:S0103-50532014000300010Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2014-03-19T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Simultaneous determination of paracetamol and ibuprofen in pharmaceutical samples by differential pulse voltammetry using a boron-doped diamond electrode
title Simultaneous determination of paracetamol and ibuprofen in pharmaceutical samples by differential pulse voltammetry using a boron-doped diamond electrode
spellingShingle Simultaneous determination of paracetamol and ibuprofen in pharmaceutical samples by differential pulse voltammetry using a boron-doped diamond electrode
Lima,Amanda B.
simultaneous analysis
differential pulse voltammetry
ibuprofen
paracetamol
title_short Simultaneous determination of paracetamol and ibuprofen in pharmaceutical samples by differential pulse voltammetry using a boron-doped diamond electrode
title_full Simultaneous determination of paracetamol and ibuprofen in pharmaceutical samples by differential pulse voltammetry using a boron-doped diamond electrode
title_fullStr Simultaneous determination of paracetamol and ibuprofen in pharmaceutical samples by differential pulse voltammetry using a boron-doped diamond electrode
title_full_unstemmed Simultaneous determination of paracetamol and ibuprofen in pharmaceutical samples by differential pulse voltammetry using a boron-doped diamond electrode
title_sort Simultaneous determination of paracetamol and ibuprofen in pharmaceutical samples by differential pulse voltammetry using a boron-doped diamond electrode
author Lima,Amanda B.
author_facet Lima,Amanda B.
Torres,Lívia M. F. C.
Guimarães,Carlos F. R. C.
Verly,Rodrigo M.
Silva,Leonardo M. da
Carvalho Júnior,Álvaro D.
Santos,Wallans T. P. dos
author_role author
author2 Torres,Lívia M. F. C.
Guimarães,Carlos F. R. C.
Verly,Rodrigo M.
Silva,Leonardo M. da
Carvalho Júnior,Álvaro D.
Santos,Wallans T. P. dos
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Lima,Amanda B.
Torres,Lívia M. F. C.
Guimarães,Carlos F. R. C.
Verly,Rodrigo M.
Silva,Leonardo M. da
Carvalho Júnior,Álvaro D.
Santos,Wallans T. P. dos
dc.subject.por.fl_str_mv simultaneous analysis
differential pulse voltammetry
ibuprofen
paracetamol
topic simultaneous analysis
differential pulse voltammetry
ibuprofen
paracetamol
description This work presents a simple, fast and low-cost methodology for the simultaneous determination of paracetamol (PC) and ibuprofen (IB) in pharmaceutical formulations by differential pulse voltammetry using a boron-doped diamond (BDD) electrode. A well-defined oxidation peak was observed using the BDD electrode for each analyte (0.85 V for PC and 1.72 V for IB (vs. Ag/AgCl)) in 0.1 mol L-1 H2SO4 solution containing 10% (v/v) of ethanol. Calibration curves for the simultaneous determination of PC and IB showed a linear response for both drugs in a concentration range of 20 to 400 µmol L-1 (r² = 0.999), with a detection limit of 7.1 µmol L-1 for PC and 3.8 µmol L-1 for IB. The addition-recovery studies in samples were about 100% and the results were validated by chromatographic methods.
publishDate 2014
dc.date.none.fl_str_mv 2014-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532014000300010
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532014000300010
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/0103-5053.20140005
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.25 n.3 2014
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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