Biotransformation of digitoxigenin by Cochliobolus lunatus

Detalhes bibliográficos
Autor(a) principal: Pádua,Rodrigo M.
Data de Publicação: 2007
Outros Autores: Oliveira,Alaíde B., Souza Filho,José D., Takahashi,Jacqueline A., Silva,Maurício de Abreu e, Braga,Fernão C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532007000700002
Resumo: The biotransformation of digitoxigenin (1) by Cochliobolus lunatus was investigated. The biotransformation reaction was carried out in a 4-day process, resulting in the isolation of four products, whose structures were elucidated as 1beta-hydroxydigitoxigenin (2), 7beta-hydroxydigitoxigenin (3), 8beta-hydroxydigitoxigenin (4) and digitoxigenone (5). The production of these derivatives under the employed conditions has never been described so far. This is also the first report on the production of compound 4 by a biotransformation reaction.
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spelling Biotransformation of digitoxigenin by Cochliobolus lunatusdigitoxigeninCochliobolus lunatus1beta-hydroxydigitoxigenin7beta-hydroxydigitoxigenin8beta-hydroxydigitoxigenindigitoxigenoneThe biotransformation of digitoxigenin (1) by Cochliobolus lunatus was investigated. The biotransformation reaction was carried out in a 4-day process, resulting in the isolation of four products, whose structures were elucidated as 1beta-hydroxydigitoxigenin (2), 7beta-hydroxydigitoxigenin (3), 8beta-hydroxydigitoxigenin (4) and digitoxigenone (5). The production of these derivatives under the employed conditions has never been described so far. This is also the first report on the production of compound 4 by a biotransformation reaction.Sociedade Brasileira de Química2007-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532007000700002Journal of the Brazilian Chemical Society v.18 n.7 2007reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532007000700002info:eu-repo/semantics/openAccessPádua,Rodrigo M.Oliveira,Alaíde B.Souza Filho,José D.Takahashi,Jacqueline A.Silva,Maurício de Abreu eBraga,Fernão C.eng2008-01-08T00:00:00Zoai:scielo:S0103-50532007000700002Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2008-01-08T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Biotransformation of digitoxigenin by Cochliobolus lunatus
title Biotransformation of digitoxigenin by Cochliobolus lunatus
spellingShingle Biotransformation of digitoxigenin by Cochliobolus lunatus
Pádua,Rodrigo M.
digitoxigenin
Cochliobolus lunatus
1beta-hydroxydigitoxigenin
7beta-hydroxydigitoxigenin
8beta-hydroxydigitoxigenin
digitoxigenone
title_short Biotransformation of digitoxigenin by Cochliobolus lunatus
title_full Biotransformation of digitoxigenin by Cochliobolus lunatus
title_fullStr Biotransformation of digitoxigenin by Cochliobolus lunatus
title_full_unstemmed Biotransformation of digitoxigenin by Cochliobolus lunatus
title_sort Biotransformation of digitoxigenin by Cochliobolus lunatus
author Pádua,Rodrigo M.
author_facet Pádua,Rodrigo M.
Oliveira,Alaíde B.
Souza Filho,José D.
Takahashi,Jacqueline A.
Silva,Maurício de Abreu e
Braga,Fernão C.
author_role author
author2 Oliveira,Alaíde B.
Souza Filho,José D.
Takahashi,Jacqueline A.
Silva,Maurício de Abreu e
Braga,Fernão C.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Pádua,Rodrigo M.
Oliveira,Alaíde B.
Souza Filho,José D.
Takahashi,Jacqueline A.
Silva,Maurício de Abreu e
Braga,Fernão C.
dc.subject.por.fl_str_mv digitoxigenin
Cochliobolus lunatus
1beta-hydroxydigitoxigenin
7beta-hydroxydigitoxigenin
8beta-hydroxydigitoxigenin
digitoxigenone
topic digitoxigenin
Cochliobolus lunatus
1beta-hydroxydigitoxigenin
7beta-hydroxydigitoxigenin
8beta-hydroxydigitoxigenin
digitoxigenone
description The biotransformation of digitoxigenin (1) by Cochliobolus lunatus was investigated. The biotransformation reaction was carried out in a 4-day process, resulting in the isolation of four products, whose structures were elucidated as 1beta-hydroxydigitoxigenin (2), 7beta-hydroxydigitoxigenin (3), 8beta-hydroxydigitoxigenin (4) and digitoxigenone (5). The production of these derivatives under the employed conditions has never been described so far. This is also the first report on the production of compound 4 by a biotransformation reaction.
publishDate 2007
dc.date.none.fl_str_mv 2007-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532007000700002
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532007000700002
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-50532007000700002
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.18 n.7 2007
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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