Ixorine, a New Cyclopeptide Alkaloid from the Branches of Ixora brevifolia

Detalhes bibliográficos
Autor(a) principal: Medina,Rebeca P.
Data de Publicação: 2016
Outros Autores: Schuquel,Ivânia T. A., Pomini,Armando M., Silva,Cleuza C., Oliveira,Cecília M. A., Kato,Lucília, Nakamura,Celso V., Santin,Silvana M. O.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532016000400753
Resumo: The isolation and structure determination of new cyclic peptide alkaloid ixorine, along with five known constituents frangulanine, syringaresinol, cinnamtannin B-1, daucosterol and mannitol from the branches of Ixora brevifolia are described. The cyclic peptide frangulanine is being described for the first time in the Rubiaceae family. The structures were elucidated on their spectral data basis, mainly one- (1H, 13C, DEPT) and two-dimensional (COSY, NOESY, HSQC and HMBC) nuclear magnetic resonance (NMR) and by comparison with data from the literature. The mixture of two cyclopeptide alkaloids showed weak activity against Leishmania amazonensis.
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spelling Ixorine, a New Cyclopeptide Alkaloid from the Branches of Ixora brevifoliaIxora brevifoliaRubiaceaecyclopeptide alkaloidsLeishmaniaThe isolation and structure determination of new cyclic peptide alkaloid ixorine, along with five known constituents frangulanine, syringaresinol, cinnamtannin B-1, daucosterol and mannitol from the branches of Ixora brevifolia are described. The cyclic peptide frangulanine is being described for the first time in the Rubiaceae family. The structures were elucidated on their spectral data basis, mainly one- (1H, 13C, DEPT) and two-dimensional (COSY, NOESY, HSQC and HMBC) nuclear magnetic resonance (NMR) and by comparison with data from the literature. The mixture of two cyclopeptide alkaloids showed weak activity against Leishmania amazonensis.Sociedade Brasileira de Química2016-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532016000400753Journal of the Brazilian Chemical Society v.27 n.4 2016reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.5935/0103-5053.20150326info:eu-repo/semantics/openAccessMedina,Rebeca P.Schuquel,Ivânia T. A.Pomini,Armando M.Silva,Cleuza C.Oliveira,Cecília M. A.Kato,LucíliaNakamura,Celso V.Santin,Silvana M. O.eng2016-04-15T00:00:00Zoai:scielo:S0103-50532016000400753Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2016-04-15T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Ixorine, a New Cyclopeptide Alkaloid from the Branches of Ixora brevifolia
title Ixorine, a New Cyclopeptide Alkaloid from the Branches of Ixora brevifolia
spellingShingle Ixorine, a New Cyclopeptide Alkaloid from the Branches of Ixora brevifolia
Medina,Rebeca P.
Ixora brevifolia
Rubiaceae
cyclopeptide alkaloids
Leishmania
title_short Ixorine, a New Cyclopeptide Alkaloid from the Branches of Ixora brevifolia
title_full Ixorine, a New Cyclopeptide Alkaloid from the Branches of Ixora brevifolia
title_fullStr Ixorine, a New Cyclopeptide Alkaloid from the Branches of Ixora brevifolia
title_full_unstemmed Ixorine, a New Cyclopeptide Alkaloid from the Branches of Ixora brevifolia
title_sort Ixorine, a New Cyclopeptide Alkaloid from the Branches of Ixora brevifolia
author Medina,Rebeca P.
author_facet Medina,Rebeca P.
Schuquel,Ivânia T. A.
Pomini,Armando M.
Silva,Cleuza C.
Oliveira,Cecília M. A.
Kato,Lucília
Nakamura,Celso V.
Santin,Silvana M. O.
author_role author
author2 Schuquel,Ivânia T. A.
Pomini,Armando M.
Silva,Cleuza C.
Oliveira,Cecília M. A.
Kato,Lucília
Nakamura,Celso V.
Santin,Silvana M. O.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Medina,Rebeca P.
Schuquel,Ivânia T. A.
Pomini,Armando M.
Silva,Cleuza C.
Oliveira,Cecília M. A.
Kato,Lucília
Nakamura,Celso V.
Santin,Silvana M. O.
dc.subject.por.fl_str_mv Ixora brevifolia
Rubiaceae
cyclopeptide alkaloids
Leishmania
topic Ixora brevifolia
Rubiaceae
cyclopeptide alkaloids
Leishmania
description The isolation and structure determination of new cyclic peptide alkaloid ixorine, along with five known constituents frangulanine, syringaresinol, cinnamtannin B-1, daucosterol and mannitol from the branches of Ixora brevifolia are described. The cyclic peptide frangulanine is being described for the first time in the Rubiaceae family. The structures were elucidated on their spectral data basis, mainly one- (1H, 13C, DEPT) and two-dimensional (COSY, NOESY, HSQC and HMBC) nuclear magnetic resonance (NMR) and by comparison with data from the literature. The mixture of two cyclopeptide alkaloids showed weak activity against Leishmania amazonensis.
publishDate 2016
dc.date.none.fl_str_mv 2016-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532016000400753
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532016000400753
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/0103-5053.20150326
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.27 n.4 2016
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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