Anti-inflammatory and antiproliferative activities of Ixora brevifolia Benth. (Rubiaceae)

Detalhes bibliográficos
Autor(a) principal: Medina, Rebeca P. [UNESP]
Data de Publicação: 2018
Outros Autores: de Moura, Vagner M., da Silva, Cleuza C., de Oliveira, Cecília M. A., Kato, Lucilia, Pomini, Armando M., de Carvalho, João E., Ruiz, Ana Lúcia T. G., Bersani-Amado, Ciomar A., Santin, Silvana M. O.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1080/14786419.2017.1344654
http://hdl.handle.net/11449/174792
Resumo: The crude extract and fractions from the branches of Ixora brevifolia, a tree found in the Brazilian Cerrado, were tested for anti-inflammatory and in vitro antiproliferative effects. The crude extract and n-hexane fraction exhibited significant inhibition of ear oedema in mice, while n-hexane-precipitated and chloroform fractions strongly inhibited the myeloperoxidase activity in ear tissue. The n-hexane and n-hexane-precipitated fractions showed strong growth inhibition for glioma cell line and the hydromethanolic fraction inhibited the growth of leukaemia cell line.
id UNSP_85d30d9a5e2fa93664ca56f01e2652cd
oai_identifier_str oai:repositorio.unesp.br:11449/174792
network_acronym_str UNSP
network_name_str Repositório Institucional da UNESP
repository_id_str 2946
spelling Anti-inflammatory and antiproliferative activities of Ixora brevifolia Benth. (Rubiaceae)anti-inflammatory activityantiproliferative activityIxora brevifoliaRubiaceaeThe crude extract and fractions from the branches of Ixora brevifolia, a tree found in the Brazilian Cerrado, were tested for anti-inflammatory and in vitro antiproliferative effects. The crude extract and n-hexane fraction exhibited significant inhibition of ear oedema in mice, while n-hexane-precipitated and chloroform fractions strongly inhibited the myeloperoxidase activity in ear tissue. The n-hexane and n-hexane-precipitated fractions showed strong growth inhibition for glioma cell line and the hydromethanolic fraction inhibited the growth of leukaemia cell line.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Departamento de Química Universidade Estadual de MaringáInstituto de Química Universidade Federal de GoiásCentro Pluridisciplinar de Pesquisa Químicas Biológicas e Agrícolas Universidade Estadual de CampinasDepartamento de Farmacologia Universidade Estadual de MaringáNúcleo de Bioensaios Biossíntese e Ecofisiologia de Produtos Naturais (NuBBE) Departamento de Química Orgânica Instituto de Química UNESP - Univ. Estadual PaulistaNúcleo de Bioensaios Biossíntese e Ecofisiologia de Produtos Naturais (NuBBE) Departamento de Química Orgânica Instituto de Química UNESP - Univ. Estadual PaulistaUniversidade Estadual de Maringá (UEM)Universidade Federal de Goiás (UFG)Universidade Estadual de Campinas (UNICAMP)Universidade Estadual Paulista (Unesp)Medina, Rebeca P. [UNESP]de Moura, Vagner M.da Silva, Cleuza C.de Oliveira, Cecília M. A.Kato, LuciliaPomini, Armando M.de Carvalho, João E.Ruiz, Ana Lúcia T. G.Bersani-Amado, Ciomar A.Santin, Silvana M. O.2018-12-11T17:12:53Z2018-12-11T17:12:53Z2018-06-03info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1357-1360application/pdfhttp://dx.doi.org/10.1080/14786419.2017.1344654Natural Product Research, v. 32, n. 11, p. 1357-1360, 2018.1478-64271478-6419http://hdl.handle.net/11449/17479210.1080/14786419.2017.13446542-s2.0-850211847272-s2.0-85021184727.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengNatural Product Research0,671info:eu-repo/semantics/openAccess2024-01-28T06:45:05Zoai:repositorio.unesp.br:11449/174792Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-06T00:07:28.752093Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Anti-inflammatory and antiproliferative activities of Ixora brevifolia Benth. (Rubiaceae)
title Anti-inflammatory and antiproliferative activities of Ixora brevifolia Benth. (Rubiaceae)
spellingShingle Anti-inflammatory and antiproliferative activities of Ixora brevifolia Benth. (Rubiaceae)
Medina, Rebeca P. [UNESP]
anti-inflammatory activity
antiproliferative activity
Ixora brevifolia
Rubiaceae
title_short Anti-inflammatory and antiproliferative activities of Ixora brevifolia Benth. (Rubiaceae)
title_full Anti-inflammatory and antiproliferative activities of Ixora brevifolia Benth. (Rubiaceae)
title_fullStr Anti-inflammatory and antiproliferative activities of Ixora brevifolia Benth. (Rubiaceae)
title_full_unstemmed Anti-inflammatory and antiproliferative activities of Ixora brevifolia Benth. (Rubiaceae)
title_sort Anti-inflammatory and antiproliferative activities of Ixora brevifolia Benth. (Rubiaceae)
author Medina, Rebeca P. [UNESP]
author_facet Medina, Rebeca P. [UNESP]
de Moura, Vagner M.
da Silva, Cleuza C.
de Oliveira, Cecília M. A.
Kato, Lucilia
Pomini, Armando M.
de Carvalho, João E.
Ruiz, Ana Lúcia T. G.
Bersani-Amado, Ciomar A.
Santin, Silvana M. O.
author_role author
author2 de Moura, Vagner M.
da Silva, Cleuza C.
de Oliveira, Cecília M. A.
Kato, Lucilia
Pomini, Armando M.
de Carvalho, João E.
Ruiz, Ana Lúcia T. G.
Bersani-Amado, Ciomar A.
Santin, Silvana M. O.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual de Maringá (UEM)
Universidade Federal de Goiás (UFG)
Universidade Estadual de Campinas (UNICAMP)
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Medina, Rebeca P. [UNESP]
de Moura, Vagner M.
da Silva, Cleuza C.
de Oliveira, Cecília M. A.
Kato, Lucilia
Pomini, Armando M.
de Carvalho, João E.
Ruiz, Ana Lúcia T. G.
Bersani-Amado, Ciomar A.
Santin, Silvana M. O.
dc.subject.por.fl_str_mv anti-inflammatory activity
antiproliferative activity
Ixora brevifolia
Rubiaceae
topic anti-inflammatory activity
antiproliferative activity
Ixora brevifolia
Rubiaceae
description The crude extract and fractions from the branches of Ixora brevifolia, a tree found in the Brazilian Cerrado, were tested for anti-inflammatory and in vitro antiproliferative effects. The crude extract and n-hexane fraction exhibited significant inhibition of ear oedema in mice, while n-hexane-precipitated and chloroform fractions strongly inhibited the myeloperoxidase activity in ear tissue. The n-hexane and n-hexane-precipitated fractions showed strong growth inhibition for glioma cell line and the hydromethanolic fraction inhibited the growth of leukaemia cell line.
publishDate 2018
dc.date.none.fl_str_mv 2018-12-11T17:12:53Z
2018-12-11T17:12:53Z
2018-06-03
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1080/14786419.2017.1344654
Natural Product Research, v. 32, n. 11, p. 1357-1360, 2018.
1478-6427
1478-6419
http://hdl.handle.net/11449/174792
10.1080/14786419.2017.1344654
2-s2.0-85021184727
2-s2.0-85021184727.pdf
url http://dx.doi.org/10.1080/14786419.2017.1344654
http://hdl.handle.net/11449/174792
identifier_str_mv Natural Product Research, v. 32, n. 11, p. 1357-1360, 2018.
1478-6427
1478-6419
10.1080/14786419.2017.1344654
2-s2.0-85021184727
2-s2.0-85021184727.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Natural Product Research
0,671
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1357-1360
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808129586739806208

Registros relacionados