Protein structure-based design of anti-protozoal drugs

Detalhes bibliográficos
Autor(a) principal: Verlinde,Christophe L. M. J.
Data de Publicação: 2002
Outros Autores: Bressi,Jerome C., Choe,Jungwoo, Suresh,Stephen, Buckner,Frederick S., Van Voorhis,Wesley C., Michels,Paul A. M., Gelb,Michael H., Hol,Wim G. J.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532002000600018
Resumo: The repertory of drugs to fight protozoal diseases such as malaria, Chagas' disease, leishmaniasis, and African trypanosomiasis is woefully inadequate. Now, genome sequencing and structural genomics projects are quickly elucidating new drug targets, providing incredible opportunities for medicinal chemists. Here, we illustrate the power of structure-based drug design in this process by our efforts to selectively block trypanosomal glycolysis.
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spelling Protein structure-based design of anti-protozoal drugsdrug designChagas' diseaseleishmaniasismalariaAfrican trypanosomiasisGAPDHThe repertory of drugs to fight protozoal diseases such as malaria, Chagas' disease, leishmaniasis, and African trypanosomiasis is woefully inadequate. Now, genome sequencing and structural genomics projects are quickly elucidating new drug targets, providing incredible opportunities for medicinal chemists. Here, we illustrate the power of structure-based drug design in this process by our efforts to selectively block trypanosomal glycolysis.Sociedade Brasileira de Química2002-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532002000600018Journal of the Brazilian Chemical Society v.13 n.6 2002reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532002000600018info:eu-repo/semantics/openAccessVerlinde,Christophe L. M. J.Bressi,Jerome C.Choe,JungwooSuresh,StephenBuckner,Frederick S.Van Voorhis,Wesley C.Michels,Paul A. M.Gelb,Michael H.Hol,Wim G. J.eng2015-11-26T00:00:00Zoai:scielo:S0103-50532002000600018Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2015-11-26T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Protein structure-based design of anti-protozoal drugs
title Protein structure-based design of anti-protozoal drugs
spellingShingle Protein structure-based design of anti-protozoal drugs
Verlinde,Christophe L. M. J.
drug design
Chagas' disease
leishmaniasis
malaria
African trypanosomiasis
GAPDH
title_short Protein structure-based design of anti-protozoal drugs
title_full Protein structure-based design of anti-protozoal drugs
title_fullStr Protein structure-based design of anti-protozoal drugs
title_full_unstemmed Protein structure-based design of anti-protozoal drugs
title_sort Protein structure-based design of anti-protozoal drugs
author Verlinde,Christophe L. M. J.
author_facet Verlinde,Christophe L. M. J.
Bressi,Jerome C.
Choe,Jungwoo
Suresh,Stephen
Buckner,Frederick S.
Van Voorhis,Wesley C.
Michels,Paul A. M.
Gelb,Michael H.
Hol,Wim G. J.
author_role author
author2 Bressi,Jerome C.
Choe,Jungwoo
Suresh,Stephen
Buckner,Frederick S.
Van Voorhis,Wesley C.
Michels,Paul A. M.
Gelb,Michael H.
Hol,Wim G. J.
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Verlinde,Christophe L. M. J.
Bressi,Jerome C.
Choe,Jungwoo
Suresh,Stephen
Buckner,Frederick S.
Van Voorhis,Wesley C.
Michels,Paul A. M.
Gelb,Michael H.
Hol,Wim G. J.
dc.subject.por.fl_str_mv drug design
Chagas' disease
leishmaniasis
malaria
African trypanosomiasis
GAPDH
topic drug design
Chagas' disease
leishmaniasis
malaria
African trypanosomiasis
GAPDH
description The repertory of drugs to fight protozoal diseases such as malaria, Chagas' disease, leishmaniasis, and African trypanosomiasis is woefully inadequate. Now, genome sequencing and structural genomics projects are quickly elucidating new drug targets, providing incredible opportunities for medicinal chemists. Here, we illustrate the power of structure-based drug design in this process by our efforts to selectively block trypanosomal glycolysis.
publishDate 2002
dc.date.none.fl_str_mv 2002-11-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532002000600018
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532002000600018
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-50532002000600018
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.13 n.6 2002
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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