New drugs with antiprotozoal activity from marine algae: a review
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.bjp.2014.07.001 http://hdl.handle.net/11449/114630 |
Resumo: | The use of indigenous or remote popular knowledge to identify new drugs against diseases or infections is a well-known approach in medicine. The inhabitants of coastal regions are known to prepare algae extracts for the treatment of disorders and ailments such as wounds, fever and stomach aches, as for the prevention of arrhythmia. Recent trends in drug research from natural sources have indicated that marine algae are a promising source of novel biochemically active compounds, especially with antiprotozoal activity. Algae survive in a competitive environment and, therefore, developed defense strategies that have resulted in a significant level of chemical structural diversity in various metabolic pathways. The exploration of these organisms for pharmaceutical and medical purposes has provided important chemical candidates for the discovery of new agents against neglected tropical diseases, stimulating the use of sophisticated physical techniques. This current review describes the main substances biosynthesized by benthic marine algae with activity against Leishmania spp., Trypanosoma cruzi and Trypanosoma brucei; the causative agents of leishmaniasis, Chagas disease and African trypanosomiasis, respectively. Emphasis is given to secondary metabolites and crude extracts prepared from marine algae. |
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New drugs with antiprotozoal activity from marine algae: a reviewLeishmaniasisAfrican trypanosomiasisChagas diseaseNatural productsAlgaeDrug discoveryThe use of indigenous or remote popular knowledge to identify new drugs against diseases or infections is a well-known approach in medicine. The inhabitants of coastal regions are known to prepare algae extracts for the treatment of disorders and ailments such as wounds, fever and stomach aches, as for the prevention of arrhythmia. Recent trends in drug research from natural sources have indicated that marine algae are a promising source of novel biochemically active compounds, especially with antiprotozoal activity. Algae survive in a competitive environment and, therefore, developed defense strategies that have resulted in a significant level of chemical structural diversity in various metabolic pathways. The exploration of these organisms for pharmaceutical and medical purposes has provided important chemical candidates for the discovery of new agents against neglected tropical diseases, stimulating the use of sophisticated physical techniques. This current review describes the main substances biosynthesized by benthic marine algae with activity against Leishmania spp., Trypanosoma cruzi and Trypanosoma brucei; the causative agents of leishmaniasis, Chagas disease and African trypanosomiasis, respectively. Emphasis is given to secondary metabolites and crude extracts prepared from marine algae.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Universidade Estadual Paulista Julio de Mesquita Filho Faculdade de Ciências Farmacêuticas Departamento de Análises ClínicasUniversidade Estadual Paulista Julio de Mesquita Filho Instituto de Química de AraraquaraUniversidade Estadual Paulista Julio de Mesquita Filho Instituto de QuímicaUniversidade de São Paulo Instituto de Química Departamento de BioquímicaUniversidade Estadual Paulista Julio de Mesquita Filho Faculdade de Ciências Farmacêuticas Departamento de Análises ClínicasUniversidade Estadual Paulista Julio de Mesquita Filho Instituto de Química de AraraquaraUniversidade Estadual Paulista Julio de Mesquita Filho Instituto de QuímicaSociedade Brasileira de FarmacognosiaUniversidade Estadual Paulista (Unesp)Universidade de São Paulo (USP)Torres, Fábio A.e.Passalacqua, Thais G.Velásquez, Angela M.a.Souza, Rodrigo A. DeColepicolo, PioGraminha, Márcia A.s.2015-02-02T12:39:43Z2015-02-02T12:39:43Z2014-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article265-276application/pdfhttp://dx.doi.org/10.1016/j.bjp.2014.07.001Revista Brasileira de Farmacognosia. Sociedade Brasileira de Farmacognosia, v. 24, n. 3, p. 265-276, 2014.0102-695Xhttp://hdl.handle.net/11449/11463010.1016/j.bjp.2014.07.001S0102-695X2014000300265S0102-695X2014000300265.pdfSciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengRevista Brasileira de Farmacognosia1.596info:eu-repo/semantics/openAccess2024-06-21T15:18:45Zoai:repositorio.unesp.br:11449/114630Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-06-21T15:18:45Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
New drugs with antiprotozoal activity from marine algae: a review |
title |
New drugs with antiprotozoal activity from marine algae: a review |
spellingShingle |
New drugs with antiprotozoal activity from marine algae: a review Torres, Fábio A.e. Leishmaniasis African trypanosomiasis Chagas disease Natural products Algae Drug discovery |
title_short |
New drugs with antiprotozoal activity from marine algae: a review |
title_full |
New drugs with antiprotozoal activity from marine algae: a review |
title_fullStr |
New drugs with antiprotozoal activity from marine algae: a review |
title_full_unstemmed |
New drugs with antiprotozoal activity from marine algae: a review |
title_sort |
New drugs with antiprotozoal activity from marine algae: a review |
author |
Torres, Fábio A.e. |
author_facet |
Torres, Fábio A.e. Passalacqua, Thais G. Velásquez, Angela M.a. Souza, Rodrigo A. De Colepicolo, Pio Graminha, Márcia A.s. |
author_role |
author |
author2 |
Passalacqua, Thais G. Velásquez, Angela M.a. Souza, Rodrigo A. De Colepicolo, Pio Graminha, Márcia A.s. |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Torres, Fábio A.e. Passalacqua, Thais G. Velásquez, Angela M.a. Souza, Rodrigo A. De Colepicolo, Pio Graminha, Márcia A.s. |
dc.subject.por.fl_str_mv |
Leishmaniasis African trypanosomiasis Chagas disease Natural products Algae Drug discovery |
topic |
Leishmaniasis African trypanosomiasis Chagas disease Natural products Algae Drug discovery |
description |
The use of indigenous or remote popular knowledge to identify new drugs against diseases or infections is a well-known approach in medicine. The inhabitants of coastal regions are known to prepare algae extracts for the treatment of disorders and ailments such as wounds, fever and stomach aches, as for the prevention of arrhythmia. Recent trends in drug research from natural sources have indicated that marine algae are a promising source of novel biochemically active compounds, especially with antiprotozoal activity. Algae survive in a competitive environment and, therefore, developed defense strategies that have resulted in a significant level of chemical structural diversity in various metabolic pathways. The exploration of these organisms for pharmaceutical and medical purposes has provided important chemical candidates for the discovery of new agents against neglected tropical diseases, stimulating the use of sophisticated physical techniques. This current review describes the main substances biosynthesized by benthic marine algae with activity against Leishmania spp., Trypanosoma cruzi and Trypanosoma brucei; the causative agents of leishmaniasis, Chagas disease and African trypanosomiasis, respectively. Emphasis is given to secondary metabolites and crude extracts prepared from marine algae. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-06-01 2015-02-02T12:39:43Z 2015-02-02T12:39:43Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.bjp.2014.07.001 Revista Brasileira de Farmacognosia. Sociedade Brasileira de Farmacognosia, v. 24, n. 3, p. 265-276, 2014. 0102-695X http://hdl.handle.net/11449/114630 10.1016/j.bjp.2014.07.001 S0102-695X2014000300265 S0102-695X2014000300265.pdf |
url |
http://dx.doi.org/10.1016/j.bjp.2014.07.001 http://hdl.handle.net/11449/114630 |
identifier_str_mv |
Revista Brasileira de Farmacognosia. Sociedade Brasileira de Farmacognosia, v. 24, n. 3, p. 265-276, 2014. 0102-695X 10.1016/j.bjp.2014.07.001 S0102-695X2014000300265 S0102-695X2014000300265.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Revista Brasileira de Farmacognosia 1.596 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
265-276 application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
dc.source.none.fl_str_mv |
SciELO reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1803045329677844480 |