Vibrational and thermal properties of crystalline topiramate

Detalhes bibliográficos
Autor(a) principal: Sena Jr.,Diniz M.
Data de Publicação: 2008
Outros Autores: Freire,Paulo T. C., M. Filho,Josué, Melo,Francisco E. A., Pontes,Fenelon M., Longo,Elson, Ferreira,Odair P., Alves,Oswaldo L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532008000800022
Resumo: Topiramate, a powerful anticonvulsant drug, was investigated by X-ray diffractometry, FT-Raman, FT-IR, TGA and DTA techniques as well as by DFT calculations. From this study it was possible to tentatively assign most of the normal vibrational modes of the crystal. Thermal analysis from room temperature to 900 ºC shows that the material does not present any structural phase transition and that the decomposition occurs in a two-step exothermic process.
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spelling Vibrational and thermal properties of crystalline topiramateorganic crystalsvibrational spectraX-ray diffractionthermodynamic propertiesTopiramate, a powerful anticonvulsant drug, was investigated by X-ray diffractometry, FT-Raman, FT-IR, TGA and DTA techniques as well as by DFT calculations. From this study it was possible to tentatively assign most of the normal vibrational modes of the crystal. Thermal analysis from room temperature to 900 ºC shows that the material does not present any structural phase transition and that the decomposition occurs in a two-step exothermic process.Sociedade Brasileira de Química2008-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532008000800022Journal of the Brazilian Chemical Society v.19 n.8 2008reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532008000800022info:eu-repo/semantics/openAccessSena Jr.,Diniz M.Freire,Paulo T. C.M. Filho,JosuéMelo,Francisco E. A.Pontes,Fenelon M.Longo,ElsonFerreira,Odair P.Alves,Oswaldo L.eng2008-12-09T00:00:00Zoai:scielo:S0103-50532008000800022Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2008-12-09T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Vibrational and thermal properties of crystalline topiramate
title Vibrational and thermal properties of crystalline topiramate
spellingShingle Vibrational and thermal properties of crystalline topiramate
Sena Jr.,Diniz M.
organic crystals
vibrational spectra
X-ray diffraction
thermodynamic properties
title_short Vibrational and thermal properties of crystalline topiramate
title_full Vibrational and thermal properties of crystalline topiramate
title_fullStr Vibrational and thermal properties of crystalline topiramate
title_full_unstemmed Vibrational and thermal properties of crystalline topiramate
title_sort Vibrational and thermal properties of crystalline topiramate
author Sena Jr.,Diniz M.
author_facet Sena Jr.,Diniz M.
Freire,Paulo T. C.
M. Filho,Josué
Melo,Francisco E. A.
Pontes,Fenelon M.
Longo,Elson
Ferreira,Odair P.
Alves,Oswaldo L.
author_role author
author2 Freire,Paulo T. C.
M. Filho,Josué
Melo,Francisco E. A.
Pontes,Fenelon M.
Longo,Elson
Ferreira,Odair P.
Alves,Oswaldo L.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Sena Jr.,Diniz M.
Freire,Paulo T. C.
M. Filho,Josué
Melo,Francisco E. A.
Pontes,Fenelon M.
Longo,Elson
Ferreira,Odair P.
Alves,Oswaldo L.
dc.subject.por.fl_str_mv organic crystals
vibrational spectra
X-ray diffraction
thermodynamic properties
topic organic crystals
vibrational spectra
X-ray diffraction
thermodynamic properties
description Topiramate, a powerful anticonvulsant drug, was investigated by X-ray diffractometry, FT-Raman, FT-IR, TGA and DTA techniques as well as by DFT calculations. From this study it was possible to tentatively assign most of the normal vibrational modes of the crystal. Thermal analysis from room temperature to 900 ºC shows that the material does not present any structural phase transition and that the decomposition occurs in a two-step exothermic process.
publishDate 2008
dc.date.none.fl_str_mv 2008-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532008000800022
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532008000800022
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-50532008000800022
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.19 n.8 2008
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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