Vibrational and Thermal Properties of Crystalline Topiramate

Detalhes bibliográficos
Autor(a) principal: Sena, Diniz M.
Data de Publicação: 2008
Outros Autores: Freire, Paulo T. C., Mendes Filho, Josue, Melo, Francisco E. A., Pontes, Fenelon Martinho Lima [UNESP], Longo, Elson [UNESP], Ferreira, Odair P., Alves, Oswaldo L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/S0103-50532008000800022
http://hdl.handle.net/11449/8769
Resumo: Topiramate, a powerful anticonvulsant drug, was investigated by X-ray diffractometry, FT-Raman, FT-IR, TGA and DTA techniques as well as by DFT calculations. From this study it was possible to tentatively assign most of the normal vibrational modes of the crystal. Thermal analysis from room temperature to 900 degrees C shows that the material does not present any structural phase transition and that the decomposition occurs in a two-step exothermic process.
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spelling Vibrational and Thermal Properties of Crystalline Topiramateorganic crystalsvibrational spectraX-ray diffractionthermodynamic propertiesTopiramate, a powerful anticonvulsant drug, was investigated by X-ray diffractometry, FT-Raman, FT-IR, TGA and DTA techniques as well as by DFT calculations. From this study it was possible to tentatively assign most of the normal vibrational modes of the crystal. Thermal analysis from room temperature to 900 degrees C shows that the material does not present any structural phase transition and that the decomposition occurs in a two-step exothermic process.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação Cearense de Apoio ao Desenvolvimento Científico e Tecnológico (FUNCAP)CENAPAD-SP (project 373)Universidade Federal do Ceará (UFC), Dept Fis, BR-60455760 Fortaleza, Ceara, BrazilUniv Reg Cariri, BR-63105000 Crato, Ceara, BrazilUniv Estadual Paulista, Fac Ciencias, Bauru, SP, BrazilUniv Estadual Paulista, Inst Quim, BR-14801970 Araraquara, SP, BrazilUniv Estadual Campinas, Lab Quim Estado Solido, Inst Quim, BR-13081970 Campinas, SP, BrazilUniv Estadual Paulista, Fac Ciencias, Bauru, SP, BrazilUniv Estadual Paulista, Inst Quim, BR-14801970 Araraquara, SP, BrazilSoc Brasileira QuimicaUniversidade Federal do Ceará (UFC)Univ Reg CaririUniversidade Estadual Paulista (Unesp)Universidade Estadual de Campinas (UNICAMP)Sena, Diniz M.Freire, Paulo T. C.Mendes Filho, JosueMelo, Francisco E. A.Pontes, Fenelon Martinho Lima [UNESP]Longo, Elson [UNESP]Ferreira, Odair P.Alves, Oswaldo L.2014-05-20T13:26:57Z2014-05-20T13:26:57Z2008-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1607-1613http://dx.doi.org/10.1590/S0103-50532008000800022Journal of The Brazilian Chemical Society. São Paulo: Soc Brasileira Quimica, v. 19, n. 8, p. 1607-1613, 2008.0103-5053http://hdl.handle.net/11449/876910.1590/S0103-50532008000800022S0103-50532008000800022WOS:000261658800022S0103-50532008000800022.pdf11594803469908210000-0001-6086-5303Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of the Brazilian Chemical Society1.4440,357info:eu-repo/semantics/openAccess2024-04-29T18:17:13Zoai:repositorio.unesp.br:11449/8769Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T22:15:31.016141Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Vibrational and Thermal Properties of Crystalline Topiramate
title Vibrational and Thermal Properties of Crystalline Topiramate
spellingShingle Vibrational and Thermal Properties of Crystalline Topiramate
Sena, Diniz M.
organic crystals
vibrational spectra
X-ray diffraction
thermodynamic properties
title_short Vibrational and Thermal Properties of Crystalline Topiramate
title_full Vibrational and Thermal Properties of Crystalline Topiramate
title_fullStr Vibrational and Thermal Properties of Crystalline Topiramate
title_full_unstemmed Vibrational and Thermal Properties of Crystalline Topiramate
title_sort Vibrational and Thermal Properties of Crystalline Topiramate
author Sena, Diniz M.
author_facet Sena, Diniz M.
Freire, Paulo T. C.
Mendes Filho, Josue
Melo, Francisco E. A.
Pontes, Fenelon Martinho Lima [UNESP]
Longo, Elson [UNESP]
Ferreira, Odair P.
Alves, Oswaldo L.
author_role author
author2 Freire, Paulo T. C.
Mendes Filho, Josue
Melo, Francisco E. A.
Pontes, Fenelon Martinho Lima [UNESP]
Longo, Elson [UNESP]
Ferreira, Odair P.
Alves, Oswaldo L.
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal do Ceará (UFC)
Univ Reg Cariri
Universidade Estadual Paulista (Unesp)
Universidade Estadual de Campinas (UNICAMP)
dc.contributor.author.fl_str_mv Sena, Diniz M.
Freire, Paulo T. C.
Mendes Filho, Josue
Melo, Francisco E. A.
Pontes, Fenelon Martinho Lima [UNESP]
Longo, Elson [UNESP]
Ferreira, Odair P.
Alves, Oswaldo L.
dc.subject.por.fl_str_mv organic crystals
vibrational spectra
X-ray diffraction
thermodynamic properties
topic organic crystals
vibrational spectra
X-ray diffraction
thermodynamic properties
description Topiramate, a powerful anticonvulsant drug, was investigated by X-ray diffractometry, FT-Raman, FT-IR, TGA and DTA techniques as well as by DFT calculations. From this study it was possible to tentatively assign most of the normal vibrational modes of the crystal. Thermal analysis from room temperature to 900 degrees C shows that the material does not present any structural phase transition and that the decomposition occurs in a two-step exothermic process.
publishDate 2008
dc.date.none.fl_str_mv 2008-01-01
2014-05-20T13:26:57Z
2014-05-20T13:26:57Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0103-50532008000800022
Journal of The Brazilian Chemical Society. São Paulo: Soc Brasileira Quimica, v. 19, n. 8, p. 1607-1613, 2008.
0103-5053
http://hdl.handle.net/11449/8769
10.1590/S0103-50532008000800022
S0103-50532008000800022
WOS:000261658800022
S0103-50532008000800022.pdf
1159480346990821
0000-0001-6086-5303
url http://dx.doi.org/10.1590/S0103-50532008000800022
http://hdl.handle.net/11449/8769
identifier_str_mv Journal of The Brazilian Chemical Society. São Paulo: Soc Brasileira Quimica, v. 19, n. 8, p. 1607-1613, 2008.
0103-5053
10.1590/S0103-50532008000800022
S0103-50532008000800022
WOS:000261658800022
S0103-50532008000800022.pdf
1159480346990821
0000-0001-6086-5303
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of the Brazilian Chemical Society
1.444
0,357
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1607-1613
dc.publisher.none.fl_str_mv Soc Brasileira Quimica
publisher.none.fl_str_mv Soc Brasileira Quimica
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808129409725497344

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