Fatty acid synthase inhibitors isolated from Punica granatum L.

Detalhes bibliográficos
Autor(a) principal: Jiang,He-Zhong
Data de Publicação: 2012
Outros Autores: Ma,Qing-Yun, Fan,Hui-Jin, Liang,Wen-Juan, Huang,Sheng-Zhuo, Dai,Hao-Fu, Wang,Peng-Cheng, Ma,Xiao-Feng, Zhao,You-Xing
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532012000500014
Resumo: The aim of this work is the isolation of fatty acid synthase (FAS) inhibitors from the ethyl acetate extracts of fruit peels of Punica granatum L. Bioassay-guided chemical investigation of the fruit peels resulted in the isolation of seventeen compounds mainly including triterpenoids and phenolic compounds, from which one new oleanane-type triterpene (punicaone) along with fourteen known compounds were isolated for the first time from this plant. Seven isolates were evaluated for inhibitory activities of FAS and two compounds showed to be active. Particularly, flavogallonic acid exhibited strong FAS inhibitory activity with IC50 value of 10.3 µmol L-1.
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spelling Fatty acid synthase inhibitors isolated from Punica granatum L.fatty acid synthase (FAS)Punica granatumflavogallonic acidpunicaoneThe aim of this work is the isolation of fatty acid synthase (FAS) inhibitors from the ethyl acetate extracts of fruit peels of Punica granatum L. Bioassay-guided chemical investigation of the fruit peels resulted in the isolation of seventeen compounds mainly including triterpenoids and phenolic compounds, from which one new oleanane-type triterpene (punicaone) along with fourteen known compounds were isolated for the first time from this plant. Seven isolates were evaluated for inhibitory activities of FAS and two compounds showed to be active. Particularly, flavogallonic acid exhibited strong FAS inhibitory activity with IC50 value of 10.3 µmol L-1.Sociedade Brasileira de Química2012-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532012000500014Journal of the Brazilian Chemical Society v.23 n.5 2012reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532012000500014info:eu-repo/semantics/openAccessJiang,He-ZhongMa,Qing-YunFan,Hui-JinLiang,Wen-JuanHuang,Sheng-ZhuoDai,Hao-FuWang,Peng-ChengMa,Xiao-FengZhao,You-Xingeng2012-06-01T00:00:00Zoai:scielo:S0103-50532012000500014Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2012-06-01T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Fatty acid synthase inhibitors isolated from Punica granatum L.
title Fatty acid synthase inhibitors isolated from Punica granatum L.
spellingShingle Fatty acid synthase inhibitors isolated from Punica granatum L.
Jiang,He-Zhong
fatty acid synthase (FAS)
Punica granatum
flavogallonic acid
punicaone
title_short Fatty acid synthase inhibitors isolated from Punica granatum L.
title_full Fatty acid synthase inhibitors isolated from Punica granatum L.
title_fullStr Fatty acid synthase inhibitors isolated from Punica granatum L.
title_full_unstemmed Fatty acid synthase inhibitors isolated from Punica granatum L.
title_sort Fatty acid synthase inhibitors isolated from Punica granatum L.
author Jiang,He-Zhong
author_facet Jiang,He-Zhong
Ma,Qing-Yun
Fan,Hui-Jin
Liang,Wen-Juan
Huang,Sheng-Zhuo
Dai,Hao-Fu
Wang,Peng-Cheng
Ma,Xiao-Feng
Zhao,You-Xing
author_role author
author2 Ma,Qing-Yun
Fan,Hui-Jin
Liang,Wen-Juan
Huang,Sheng-Zhuo
Dai,Hao-Fu
Wang,Peng-Cheng
Ma,Xiao-Feng
Zhao,You-Xing
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Jiang,He-Zhong
Ma,Qing-Yun
Fan,Hui-Jin
Liang,Wen-Juan
Huang,Sheng-Zhuo
Dai,Hao-Fu
Wang,Peng-Cheng
Ma,Xiao-Feng
Zhao,You-Xing
dc.subject.por.fl_str_mv fatty acid synthase (FAS)
Punica granatum
flavogallonic acid
punicaone
topic fatty acid synthase (FAS)
Punica granatum
flavogallonic acid
punicaone
description The aim of this work is the isolation of fatty acid synthase (FAS) inhibitors from the ethyl acetate extracts of fruit peels of Punica granatum L. Bioassay-guided chemical investigation of the fruit peels resulted in the isolation of seventeen compounds mainly including triterpenoids and phenolic compounds, from which one new oleanane-type triterpene (punicaone) along with fourteen known compounds were isolated for the first time from this plant. Seven isolates were evaluated for inhibitory activities of FAS and two compounds showed to be active. Particularly, flavogallonic acid exhibited strong FAS inhibitory activity with IC50 value of 10.3 µmol L-1.
publishDate 2012
dc.date.none.fl_str_mv 2012-05-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532012000500014
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532012000500014
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-50532012000500014
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.23 n.5 2012
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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