Dextrorotatory Chromomycins from the Marine Streptomyces sp. Associated to Palythoa caribaeorum
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of the Brazilian Chemical Society (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532020000100143 |
Resumo: | A Streptomyces sp. (BRA-384) was selected among nine strains of bacteria isolated from the zoanthids Palythoa caribaeorum due to the high cytotoxic activity presented by its EtOAc extract (inhibitory concentration mean (IC50) of 2 ng mL-1) against colon cancer cell line. From the EtOAc extract of BRA-384 three new chemical entities (A6, A7 and A8) and one dextrorotatory chromomycin (A5), a promising class of anticancer compounds, were identified. The cytotoxicity of chromomycins A5 to A8 was tested against five tumor cell lines (HCT 116 (human colon adenocarcinoma), MCF-7 (human breast carcinoma), PC-3M (human metastatic prostate cancer), 501-mel (human metastatic melanoma) and MM200 (metastatic melanoma)). All chromomycins were highly potent showing IC50 values from 0.2 to 133 nM. Chromomycin A5 was consistently the most potent over all tested cells (IC50 values from 0.2 in MM200 to 7.9 nM in PC-3M), inclusive when compared to the standard chemotherapeutic agent doxorubicin, that presented IC50 values ranging from 147 to 568 nM against MM200 and MCF-7, respectively. |
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Dextrorotatory Chromomycins from the Marine Streptomyces sp. Associated to Palythoa caribaeorumPalythoa caribaeorumchromomycinscytotoxic activityA Streptomyces sp. (BRA-384) was selected among nine strains of bacteria isolated from the zoanthids Palythoa caribaeorum due to the high cytotoxic activity presented by its EtOAc extract (inhibitory concentration mean (IC50) of 2 ng mL-1) against colon cancer cell line. From the EtOAc extract of BRA-384 three new chemical entities (A6, A7 and A8) and one dextrorotatory chromomycin (A5), a promising class of anticancer compounds, were identified. The cytotoxicity of chromomycins A5 to A8 was tested against five tumor cell lines (HCT 116 (human colon adenocarcinoma), MCF-7 (human breast carcinoma), PC-3M (human metastatic prostate cancer), 501-mel (human metastatic melanoma) and MM200 (metastatic melanoma)). All chromomycins were highly potent showing IC50 values from 0.2 to 133 nM. Chromomycin A5 was consistently the most potent over all tested cells (IC50 values from 0.2 in MM200 to 7.9 nM in PC-3M), inclusive when compared to the standard chemotherapeutic agent doxorubicin, that presented IC50 values ranging from 147 to 568 nM against MM200 and MCF-7, respectively.Sociedade Brasileira de Química2020-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532020000100143Journal of the Brazilian Chemical Society v.31 n.1 2020reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.21577/0103-5053.20190144info:eu-repo/semantics/openAccessPinto,Francisco C. L.Silveira,Edilberto R.Vasconcelos,Ana Caroline L.Florêncio,Katharine G. D.Oliveira,Francisca A. S.Sahm,Bianca B.Costa-Lotufo,Letícia V.Bauermeister,AnelizeLopes,Norberto P.Wilke,Diego V.Pessoa,Otília D. L.eng2020-06-05T00:00:00Zoai:scielo:S0103-50532020000100143Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2020-06-05T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
Dextrorotatory Chromomycins from the Marine Streptomyces sp. Associated to Palythoa caribaeorum |
title |
Dextrorotatory Chromomycins from the Marine Streptomyces sp. Associated to Palythoa caribaeorum |
spellingShingle |
Dextrorotatory Chromomycins from the Marine Streptomyces sp. Associated to Palythoa caribaeorum Pinto,Francisco C. L. Palythoa caribaeorum chromomycins cytotoxic activity |
title_short |
Dextrorotatory Chromomycins from the Marine Streptomyces sp. Associated to Palythoa caribaeorum |
title_full |
Dextrorotatory Chromomycins from the Marine Streptomyces sp. Associated to Palythoa caribaeorum |
title_fullStr |
Dextrorotatory Chromomycins from the Marine Streptomyces sp. Associated to Palythoa caribaeorum |
title_full_unstemmed |
Dextrorotatory Chromomycins from the Marine Streptomyces sp. Associated to Palythoa caribaeorum |
title_sort |
Dextrorotatory Chromomycins from the Marine Streptomyces sp. Associated to Palythoa caribaeorum |
author |
Pinto,Francisco C. L. |
author_facet |
Pinto,Francisco C. L. Silveira,Edilberto R. Vasconcelos,Ana Caroline L. Florêncio,Katharine G. D. Oliveira,Francisca A. S. Sahm,Bianca B. Costa-Lotufo,Letícia V. Bauermeister,Anelize Lopes,Norberto P. Wilke,Diego V. Pessoa,Otília D. L. |
author_role |
author |
author2 |
Silveira,Edilberto R. Vasconcelos,Ana Caroline L. Florêncio,Katharine G. D. Oliveira,Francisca A. S. Sahm,Bianca B. Costa-Lotufo,Letícia V. Bauermeister,Anelize Lopes,Norberto P. Wilke,Diego V. Pessoa,Otília D. L. |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Pinto,Francisco C. L. Silveira,Edilberto R. Vasconcelos,Ana Caroline L. Florêncio,Katharine G. D. Oliveira,Francisca A. S. Sahm,Bianca B. Costa-Lotufo,Letícia V. Bauermeister,Anelize Lopes,Norberto P. Wilke,Diego V. Pessoa,Otília D. L. |
dc.subject.por.fl_str_mv |
Palythoa caribaeorum chromomycins cytotoxic activity |
topic |
Palythoa caribaeorum chromomycins cytotoxic activity |
description |
A Streptomyces sp. (BRA-384) was selected among nine strains of bacteria isolated from the zoanthids Palythoa caribaeorum due to the high cytotoxic activity presented by its EtOAc extract (inhibitory concentration mean (IC50) of 2 ng mL-1) against colon cancer cell line. From the EtOAc extract of BRA-384 three new chemical entities (A6, A7 and A8) and one dextrorotatory chromomycin (A5), a promising class of anticancer compounds, were identified. The cytotoxicity of chromomycins A5 to A8 was tested against five tumor cell lines (HCT 116 (human colon adenocarcinoma), MCF-7 (human breast carcinoma), PC-3M (human metastatic prostate cancer), 501-mel (human metastatic melanoma) and MM200 (metastatic melanoma)). All chromomycins were highly potent showing IC50 values from 0.2 to 133 nM. Chromomycin A5 was consistently the most potent over all tested cells (IC50 values from 0.2 in MM200 to 7.9 nM in PC-3M), inclusive when compared to the standard chemotherapeutic agent doxorubicin, that presented IC50 values ranging from 147 to 568 nM against MM200 and MCF-7, respectively. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532020000100143 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532020000100143 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.21577/0103-5053.20190144 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Journal of the Brazilian Chemical Society v.31 n.1 2020 reponame:Journal of the Brazilian Chemical Society (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Journal of the Brazilian Chemical Society (Online) |
collection |
Journal of the Brazilian Chemical Society (Online) |
repository.name.fl_str_mv |
Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
||office@jbcs.sbq.org.br |
_version_ |
1750318182551257088 |