Dextrorotatory Chromomycins from the Marine Streptomyces sp. Associated to Palythoa caribaeorum

Detalhes bibliográficos
Autor(a) principal: Pinto,Francisco C. L.
Data de Publicação: 2020
Outros Autores: Silveira,Edilberto R., Vasconcelos,Ana Caroline L., Florêncio,Katharine G. D., Oliveira,Francisca A. S., Sahm,Bianca B., Costa-Lotufo,Letícia V., Bauermeister,Anelize, Lopes,Norberto P., Wilke,Diego V., Pessoa,Otília D. L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532020000100143
Resumo: A Streptomyces sp. (BRA-384) was selected among nine strains of bacteria isolated from the zoanthids Palythoa caribaeorum due to the high cytotoxic activity presented by its EtOAc extract (inhibitory concentration mean (IC50) of 2 ng mL-1) against colon cancer cell line. From the EtOAc extract of BRA-384 three new chemical entities (A6, A7 and A8) and one dextrorotatory chromomycin (A5), a promising class of anticancer compounds, were identified. The cytotoxicity of chromomycins A5 to A8 was tested against five tumor cell lines (HCT 116 (human colon adenocarcinoma), MCF-7 (human breast carcinoma), PC-3M (human metastatic prostate cancer), 501-mel (human metastatic melanoma) and MM200 (metastatic melanoma)). All chromomycins were highly potent showing IC50 values from 0.2 to 133 nM. Chromomycin A5 was consistently the most potent over all tested cells (IC50 values from 0.2 in MM200 to 7.9 nM in PC-3M), inclusive when compared to the standard chemotherapeutic agent doxorubicin, that presented IC50 values ranging from 147 to 568 nM against MM200 and MCF-7, respectively.
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spelling Dextrorotatory Chromomycins from the Marine Streptomyces sp. Associated to Palythoa caribaeorumPalythoa caribaeorumchromomycinscytotoxic activityA Streptomyces sp. (BRA-384) was selected among nine strains of bacteria isolated from the zoanthids Palythoa caribaeorum due to the high cytotoxic activity presented by its EtOAc extract (inhibitory concentration mean (IC50) of 2 ng mL-1) against colon cancer cell line. From the EtOAc extract of BRA-384 three new chemical entities (A6, A7 and A8) and one dextrorotatory chromomycin (A5), a promising class of anticancer compounds, were identified. The cytotoxicity of chromomycins A5 to A8 was tested against five tumor cell lines (HCT 116 (human colon adenocarcinoma), MCF-7 (human breast carcinoma), PC-3M (human metastatic prostate cancer), 501-mel (human metastatic melanoma) and MM200 (metastatic melanoma)). All chromomycins were highly potent showing IC50 values from 0.2 to 133 nM. Chromomycin A5 was consistently the most potent over all tested cells (IC50 values from 0.2 in MM200 to 7.9 nM in PC-3M), inclusive when compared to the standard chemotherapeutic agent doxorubicin, that presented IC50 values ranging from 147 to 568 nM against MM200 and MCF-7, respectively.Sociedade Brasileira de Química2020-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532020000100143Journal of the Brazilian Chemical Society v.31 n.1 2020reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.21577/0103-5053.20190144info:eu-repo/semantics/openAccessPinto,Francisco C. L.Silveira,Edilberto R.Vasconcelos,Ana Caroline L.Florêncio,Katharine G. D.Oliveira,Francisca A. S.Sahm,Bianca B.Costa-Lotufo,Letícia V.Bauermeister,AnelizeLopes,Norberto P.Wilke,Diego V.Pessoa,Otília D. L.eng2020-06-05T00:00:00Zoai:scielo:S0103-50532020000100143Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2020-06-05T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Dextrorotatory Chromomycins from the Marine Streptomyces sp. Associated to Palythoa caribaeorum
title Dextrorotatory Chromomycins from the Marine Streptomyces sp. Associated to Palythoa caribaeorum
spellingShingle Dextrorotatory Chromomycins from the Marine Streptomyces sp. Associated to Palythoa caribaeorum
Pinto,Francisco C. L.
Palythoa caribaeorum
chromomycins
cytotoxic activity
title_short Dextrorotatory Chromomycins from the Marine Streptomyces sp. Associated to Palythoa caribaeorum
title_full Dextrorotatory Chromomycins from the Marine Streptomyces sp. Associated to Palythoa caribaeorum
title_fullStr Dextrorotatory Chromomycins from the Marine Streptomyces sp. Associated to Palythoa caribaeorum
title_full_unstemmed Dextrorotatory Chromomycins from the Marine Streptomyces sp. Associated to Palythoa caribaeorum
title_sort Dextrorotatory Chromomycins from the Marine Streptomyces sp. Associated to Palythoa caribaeorum
author Pinto,Francisco C. L.
author_facet Pinto,Francisco C. L.
Silveira,Edilberto R.
Vasconcelos,Ana Caroline L.
Florêncio,Katharine G. D.
Oliveira,Francisca A. S.
Sahm,Bianca B.
Costa-Lotufo,Letícia V.
Bauermeister,Anelize
Lopes,Norberto P.
Wilke,Diego V.
Pessoa,Otília D. L.
author_role author
author2 Silveira,Edilberto R.
Vasconcelos,Ana Caroline L.
Florêncio,Katharine G. D.
Oliveira,Francisca A. S.
Sahm,Bianca B.
Costa-Lotufo,Letícia V.
Bauermeister,Anelize
Lopes,Norberto P.
Wilke,Diego V.
Pessoa,Otília D. L.
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Pinto,Francisco C. L.
Silveira,Edilberto R.
Vasconcelos,Ana Caroline L.
Florêncio,Katharine G. D.
Oliveira,Francisca A. S.
Sahm,Bianca B.
Costa-Lotufo,Letícia V.
Bauermeister,Anelize
Lopes,Norberto P.
Wilke,Diego V.
Pessoa,Otília D. L.
dc.subject.por.fl_str_mv Palythoa caribaeorum
chromomycins
cytotoxic activity
topic Palythoa caribaeorum
chromomycins
cytotoxic activity
description A Streptomyces sp. (BRA-384) was selected among nine strains of bacteria isolated from the zoanthids Palythoa caribaeorum due to the high cytotoxic activity presented by its EtOAc extract (inhibitory concentration mean (IC50) of 2 ng mL-1) against colon cancer cell line. From the EtOAc extract of BRA-384 three new chemical entities (A6, A7 and A8) and one dextrorotatory chromomycin (A5), a promising class of anticancer compounds, were identified. The cytotoxicity of chromomycins A5 to A8 was tested against five tumor cell lines (HCT 116 (human colon adenocarcinoma), MCF-7 (human breast carcinoma), PC-3M (human metastatic prostate cancer), 501-mel (human metastatic melanoma) and MM200 (metastatic melanoma)). All chromomycins were highly potent showing IC50 values from 0.2 to 133 nM. Chromomycin A5 was consistently the most potent over all tested cells (IC50 values from 0.2 in MM200 to 7.9 nM in PC-3M), inclusive when compared to the standard chemotherapeutic agent doxorubicin, that presented IC50 values ranging from 147 to 568 nM against MM200 and MCF-7, respectively.
publishDate 2020
dc.date.none.fl_str_mv 2020-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532020000100143
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532020000100143
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.21577/0103-5053.20190144
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.31 n.1 2020
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
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