Steroids from the Brazilian Zoanthids Palythoa caribaeorum and Palythoa variabilis

Detalhes bibliográficos
Autor(a) principal: Pinto,Francisco C. L.
Data de Publicação: 2017
Outros Autores: Almeida,José Gustavo L., Silveira,Edilberto R., Costa,Arinice M., Guimarães,Larissa A., Wilke,Diego V., Costa-Lotufo,Letícia V., Torres,Maria da Conceição M., Pessoa,Otília Deusdênia L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532017000300485
Resumo: Two unreported ergostane-type sterols 24(R)-7α-hydroperoxy-ergost-5-en-3β-ol and 6β-carboxyl-24(R)-(8→6)-abeo-ergostan-3β,5β-diol, along with seven known ones were isolated from the hexane and alcohol extracts from the zoanthids Palythoa caribaeorum and Palythoa variabilis. The structures of the new compounds were determined using spectroscopic techniques, including 1D and 2D nuclear magnetic resonance (NMR), high-resolution electrospray ionization mass spectrometry (HRESIMS), and comparison with data previously published. 6β-Carboxyl-24(R)-(8→6)-abeo-ergostan-3β,5β-diol showed moderate cytotoxicity against colon cancer cells (HCT-116) as previously described for others abeo-sterol derivatives.
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spelling Steroids from the Brazilian Zoanthids Palythoa caribaeorum and Palythoa variabilisPalythoa caribaeorumPalythoa variabilisergostane sterolscytotoxic activityTwo unreported ergostane-type sterols 24(R)-7α-hydroperoxy-ergost-5-en-3β-ol and 6β-carboxyl-24(R)-(8→6)-abeo-ergostan-3β,5β-diol, along with seven known ones were isolated from the hexane and alcohol extracts from the zoanthids Palythoa caribaeorum and Palythoa variabilis. The structures of the new compounds were determined using spectroscopic techniques, including 1D and 2D nuclear magnetic resonance (NMR), high-resolution electrospray ionization mass spectrometry (HRESIMS), and comparison with data previously published. 6β-Carboxyl-24(R)-(8→6)-abeo-ergostan-3β,5β-diol showed moderate cytotoxicity against colon cancer cells (HCT-116) as previously described for others abeo-sterol derivatives.Sociedade Brasileira de Química2017-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532017000300485Journal of the Brazilian Chemical Society v.28 n.3 2017reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.21577/0103-5053.20160323info:eu-repo/semantics/openAccessPinto,Francisco C. L.Almeida,José Gustavo L.Silveira,Edilberto R.Costa,Arinice M.Guimarães,Larissa A.Wilke,Diego V.Costa-Lotufo,Letícia V.Torres,Maria da Conceição M.Pessoa,Otília Deusdênia L.eng2017-02-10T00:00:00Zoai:scielo:S0103-50532017000300485Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2017-02-10T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Steroids from the Brazilian Zoanthids Palythoa caribaeorum and Palythoa variabilis
title Steroids from the Brazilian Zoanthids Palythoa caribaeorum and Palythoa variabilis
spellingShingle Steroids from the Brazilian Zoanthids Palythoa caribaeorum and Palythoa variabilis
Pinto,Francisco C. L.
Palythoa caribaeorum
Palythoa variabilis
ergostane sterols
cytotoxic activity
title_short Steroids from the Brazilian Zoanthids Palythoa caribaeorum and Palythoa variabilis
title_full Steroids from the Brazilian Zoanthids Palythoa caribaeorum and Palythoa variabilis
title_fullStr Steroids from the Brazilian Zoanthids Palythoa caribaeorum and Palythoa variabilis
title_full_unstemmed Steroids from the Brazilian Zoanthids Palythoa caribaeorum and Palythoa variabilis
title_sort Steroids from the Brazilian Zoanthids Palythoa caribaeorum and Palythoa variabilis
author Pinto,Francisco C. L.
author_facet Pinto,Francisco C. L.
Almeida,José Gustavo L.
Silveira,Edilberto R.
Costa,Arinice M.
Guimarães,Larissa A.
Wilke,Diego V.
Costa-Lotufo,Letícia V.
Torres,Maria da Conceição M.
Pessoa,Otília Deusdênia L.
author_role author
author2 Almeida,José Gustavo L.
Silveira,Edilberto R.
Costa,Arinice M.
Guimarães,Larissa A.
Wilke,Diego V.
Costa-Lotufo,Letícia V.
Torres,Maria da Conceição M.
Pessoa,Otília Deusdênia L.
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Pinto,Francisco C. L.
Almeida,José Gustavo L.
Silveira,Edilberto R.
Costa,Arinice M.
Guimarães,Larissa A.
Wilke,Diego V.
Costa-Lotufo,Letícia V.
Torres,Maria da Conceição M.
Pessoa,Otília Deusdênia L.
dc.subject.por.fl_str_mv Palythoa caribaeorum
Palythoa variabilis
ergostane sterols
cytotoxic activity
topic Palythoa caribaeorum
Palythoa variabilis
ergostane sterols
cytotoxic activity
description Two unreported ergostane-type sterols 24(R)-7α-hydroperoxy-ergost-5-en-3β-ol and 6β-carboxyl-24(R)-(8→6)-abeo-ergostan-3β,5β-diol, along with seven known ones were isolated from the hexane and alcohol extracts from the zoanthids Palythoa caribaeorum and Palythoa variabilis. The structures of the new compounds were determined using spectroscopic techniques, including 1D and 2D nuclear magnetic resonance (NMR), high-resolution electrospray ionization mass spectrometry (HRESIMS), and comparison with data previously published. 6β-Carboxyl-24(R)-(8→6)-abeo-ergostan-3β,5β-diol showed moderate cytotoxicity against colon cancer cells (HCT-116) as previously described for others abeo-sterol derivatives.
publishDate 2017
dc.date.none.fl_str_mv 2017-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532017000300485
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532017000300485
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.21577/0103-5053.20160323
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.28 n.3 2017
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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