Development and Characterization of Vitamin A-Loaded Solid Lipid Nanoparticles for Topical Application
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of the Brazilian Chemical Society (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532017000701177 |
Resumo: | Vitamin A and its esters are commonly found in topical applications because of their advantageous properties, however, have the drawback that are highly sensitive to ultraviolet radiation. The aim of this work was to develop and characterize a novel formulation of solid lipid nanoparticles suitable for topical applications in order to protect vitamin A from degradation. Vitamin A-loaded nanoparticles were successfully prepared by hot homogenization employing Gelucire 44/14® and cetyl alcohol as carrier materials, showing an entrapment efficiency of more than 90%. Particle size, measured by dynamic light scattering, was ca. 40 nm, while transmission electron microscopy images showed that dried nanoparticles were spherical with an average size of about 30-50 nm. Small angle X-ray scattering was used to study their aspect ratio and their physicochemical properties were evaluated by differential scanning calorimetry, infrared spectroscopy and X-ray powder diffraction, additionally, stability of vitamin A was studied by UV-Vis spectroscopy. |
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Development and Characterization of Vitamin A-Loaded Solid Lipid Nanoparticles for Topical Applicationsolid lipid nanoparticlesvitamin Atopical deliveryVitamin A and its esters are commonly found in topical applications because of their advantageous properties, however, have the drawback that are highly sensitive to ultraviolet radiation. The aim of this work was to develop and characterize a novel formulation of solid lipid nanoparticles suitable for topical applications in order to protect vitamin A from degradation. Vitamin A-loaded nanoparticles were successfully prepared by hot homogenization employing Gelucire 44/14® and cetyl alcohol as carrier materials, showing an entrapment efficiency of more than 90%. Particle size, measured by dynamic light scattering, was ca. 40 nm, while transmission electron microscopy images showed that dried nanoparticles were spherical with an average size of about 30-50 nm. Small angle X-ray scattering was used to study their aspect ratio and their physicochemical properties were evaluated by differential scanning calorimetry, infrared spectroscopy and X-ray powder diffraction, additionally, stability of vitamin A was studied by UV-Vis spectroscopy.Sociedade Brasileira de Química2017-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532017000701177Journal of the Brazilian Chemical Society v.28 n.7 2017reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.21577/0103-5053.20160276info:eu-repo/semantics/openAccessArgimón,MauricioRomero,MarianoMiranda,PabloMombrú,Álvaro W.Miraballes,IrisZimet,PatriciaPardo,Helenaeng2017-06-23T00:00:00Zoai:scielo:S0103-50532017000701177Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2017-06-23T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
Development and Characterization of Vitamin A-Loaded Solid Lipid Nanoparticles for Topical Application |
title |
Development and Characterization of Vitamin A-Loaded Solid Lipid Nanoparticles for Topical Application |
spellingShingle |
Development and Characterization of Vitamin A-Loaded Solid Lipid Nanoparticles for Topical Application Argimón,Mauricio solid lipid nanoparticles vitamin A topical delivery |
title_short |
Development and Characterization of Vitamin A-Loaded Solid Lipid Nanoparticles for Topical Application |
title_full |
Development and Characterization of Vitamin A-Loaded Solid Lipid Nanoparticles for Topical Application |
title_fullStr |
Development and Characterization of Vitamin A-Loaded Solid Lipid Nanoparticles for Topical Application |
title_full_unstemmed |
Development and Characterization of Vitamin A-Loaded Solid Lipid Nanoparticles for Topical Application |
title_sort |
Development and Characterization of Vitamin A-Loaded Solid Lipid Nanoparticles for Topical Application |
author |
Argimón,Mauricio |
author_facet |
Argimón,Mauricio Romero,Mariano Miranda,Pablo Mombrú,Álvaro W. Miraballes,Iris Zimet,Patricia Pardo,Helena |
author_role |
author |
author2 |
Romero,Mariano Miranda,Pablo Mombrú,Álvaro W. Miraballes,Iris Zimet,Patricia Pardo,Helena |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Argimón,Mauricio Romero,Mariano Miranda,Pablo Mombrú,Álvaro W. Miraballes,Iris Zimet,Patricia Pardo,Helena |
dc.subject.por.fl_str_mv |
solid lipid nanoparticles vitamin A topical delivery |
topic |
solid lipid nanoparticles vitamin A topical delivery |
description |
Vitamin A and its esters are commonly found in topical applications because of their advantageous properties, however, have the drawback that are highly sensitive to ultraviolet radiation. The aim of this work was to develop and characterize a novel formulation of solid lipid nanoparticles suitable for topical applications in order to protect vitamin A from degradation. Vitamin A-loaded nanoparticles were successfully prepared by hot homogenization employing Gelucire 44/14® and cetyl alcohol as carrier materials, showing an entrapment efficiency of more than 90%. Particle size, measured by dynamic light scattering, was ca. 40 nm, while transmission electron microscopy images showed that dried nanoparticles were spherical with an average size of about 30-50 nm. Small angle X-ray scattering was used to study their aspect ratio and their physicochemical properties were evaluated by differential scanning calorimetry, infrared spectroscopy and X-ray powder diffraction, additionally, stability of vitamin A was studied by UV-Vis spectroscopy. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-07-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532017000701177 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532017000701177 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.21577/0103-5053.20160276 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Journal of the Brazilian Chemical Society v.28 n.7 2017 reponame:Journal of the Brazilian Chemical Society (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Journal of the Brazilian Chemical Society (Online) |
collection |
Journal of the Brazilian Chemical Society (Online) |
repository.name.fl_str_mv |
Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
||office@jbcs.sbq.org.br |
_version_ |
1750318179591127040 |