Immunomodulatory effects of palladium(II) complexes of 1,2,4-triazole on murine peritoneal macrophages

Detalhes bibliográficos
Autor(a) principal: Bego,Amadeu M.
Data de Publicação: 2009
Outros Autores: Frem,Regina C. G., Netto,Adelino V.G., Mauro,Antonio E., Ananias,Sandra R., Carlos,Iracilda Z., Rocha,Michelle C. da
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532009000300005
Resumo: The 1,2,4-triazolyl-bridged polynuclear complexes [{PdCl2(µ-Htrz)}n] (1) and [{PdBr2(µ-Htrz)}n] (2) have been obtained in this work. Compound 1 is prepared by the displacement of acetonitrile from [PdCl2(MeCN)2] by 1,2,4-triazole (Htrz). Further addition of potassium bromide to the reaction medium afforded complex 2. The new complexes have been isolated, purified and characterized by means of elemental analysis, IR and UV-visible electronic spectroscopies and thermogravimetric (TG) curves. The experimental data suggested that, in both cases, the coordination of 1,2,4-Htrz takes place through the N(2) and N(4) atoms, bridging the palladium centers. The square-planar coordination polyhedron of palladium(II) is determined by two nitrogen atoms from the triazole ligands, while the other two coordination positions are occupied by the chloro (1) or bromo (2) ligands. TG curves indicated that the nature of the anionic ligand does not affect significantly the thermal stability of 1 and 2. The final products of the thermal decompositions were identified as metallic palladium by X-ray powder diffractometry. Preliminary tests involving the evaluation of the effects of compounds 1, 2 and Htrz on H2O2 and NO production in cultures of peritoneal macrophages from BALB/c mice were carried out in vitro.
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spelling Immunomodulatory effects of palladium(II) complexes of 1,2,4-triazole on murine peritoneal macrophagespalladium(II) complexes1,2,4-triazolemacrophagesnitric oxidehydrogen peroxideThe 1,2,4-triazolyl-bridged polynuclear complexes [{PdCl2(µ-Htrz)}n] (1) and [{PdBr2(µ-Htrz)}n] (2) have been obtained in this work. Compound 1 is prepared by the displacement of acetonitrile from [PdCl2(MeCN)2] by 1,2,4-triazole (Htrz). Further addition of potassium bromide to the reaction medium afforded complex 2. The new complexes have been isolated, purified and characterized by means of elemental analysis, IR and UV-visible electronic spectroscopies and thermogravimetric (TG) curves. The experimental data suggested that, in both cases, the coordination of 1,2,4-Htrz takes place through the N(2) and N(4) atoms, bridging the palladium centers. The square-planar coordination polyhedron of palladium(II) is determined by two nitrogen atoms from the triazole ligands, while the other two coordination positions are occupied by the chloro (1) or bromo (2) ligands. TG curves indicated that the nature of the anionic ligand does not affect significantly the thermal stability of 1 and 2. The final products of the thermal decompositions were identified as metallic palladium by X-ray powder diffractometry. Preliminary tests involving the evaluation of the effects of compounds 1, 2 and Htrz on H2O2 and NO production in cultures of peritoneal macrophages from BALB/c mice were carried out in vitro.Sociedade Brasileira de Química2009-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532009000300005Journal of the Brazilian Chemical Society v.20 n.3 2009reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532009000300005info:eu-repo/semantics/openAccessBego,Amadeu M.Frem,Regina C. G.Netto,Adelino V.G.Mauro,Antonio E.Ananias,Sandra R.Carlos,Iracilda Z.Rocha,Michelle C. daeng2009-05-25T00:00:00Zoai:scielo:S0103-50532009000300005Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2009-05-25T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Immunomodulatory effects of palladium(II) complexes of 1,2,4-triazole on murine peritoneal macrophages
title Immunomodulatory effects of palladium(II) complexes of 1,2,4-triazole on murine peritoneal macrophages
spellingShingle Immunomodulatory effects of palladium(II) complexes of 1,2,4-triazole on murine peritoneal macrophages
Bego,Amadeu M.
palladium(II) complexes
1,2,4-triazole
macrophages
nitric oxide
hydrogen peroxide
title_short Immunomodulatory effects of palladium(II) complexes of 1,2,4-triazole on murine peritoneal macrophages
title_full Immunomodulatory effects of palladium(II) complexes of 1,2,4-triazole on murine peritoneal macrophages
title_fullStr Immunomodulatory effects of palladium(II) complexes of 1,2,4-triazole on murine peritoneal macrophages
title_full_unstemmed Immunomodulatory effects of palladium(II) complexes of 1,2,4-triazole on murine peritoneal macrophages
title_sort Immunomodulatory effects of palladium(II) complexes of 1,2,4-triazole on murine peritoneal macrophages
author Bego,Amadeu M.
author_facet Bego,Amadeu M.
Frem,Regina C. G.
Netto,Adelino V.G.
Mauro,Antonio E.
Ananias,Sandra R.
Carlos,Iracilda Z.
Rocha,Michelle C. da
author_role author
author2 Frem,Regina C. G.
Netto,Adelino V.G.
Mauro,Antonio E.
Ananias,Sandra R.
Carlos,Iracilda Z.
Rocha,Michelle C. da
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Bego,Amadeu M.
Frem,Regina C. G.
Netto,Adelino V.G.
Mauro,Antonio E.
Ananias,Sandra R.
Carlos,Iracilda Z.
Rocha,Michelle C. da
dc.subject.por.fl_str_mv palladium(II) complexes
1,2,4-triazole
macrophages
nitric oxide
hydrogen peroxide
topic palladium(II) complexes
1,2,4-triazole
macrophages
nitric oxide
hydrogen peroxide
description The 1,2,4-triazolyl-bridged polynuclear complexes [{PdCl2(µ-Htrz)}n] (1) and [{PdBr2(µ-Htrz)}n] (2) have been obtained in this work. Compound 1 is prepared by the displacement of acetonitrile from [PdCl2(MeCN)2] by 1,2,4-triazole (Htrz). Further addition of potassium bromide to the reaction medium afforded complex 2. The new complexes have been isolated, purified and characterized by means of elemental analysis, IR and UV-visible electronic spectroscopies and thermogravimetric (TG) curves. The experimental data suggested that, in both cases, the coordination of 1,2,4-Htrz takes place through the N(2) and N(4) atoms, bridging the palladium centers. The square-planar coordination polyhedron of palladium(II) is determined by two nitrogen atoms from the triazole ligands, while the other two coordination positions are occupied by the chloro (1) or bromo (2) ligands. TG curves indicated that the nature of the anionic ligand does not affect significantly the thermal stability of 1 and 2. The final products of the thermal decompositions were identified as metallic palladium by X-ray powder diffractometry. Preliminary tests involving the evaluation of the effects of compounds 1, 2 and Htrz on H2O2 and NO production in cultures of peritoneal macrophages from BALB/c mice were carried out in vitro.
publishDate 2009
dc.date.none.fl_str_mv 2009-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532009000300005
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dc.language.iso.fl_str_mv eng
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dc.relation.none.fl_str_mv 10.1590/S0103-50532009000300005
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.20 n.3 2009
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
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collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
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