Immunomodulatory effects of palladium(II) complexes of 1,2,4-triazole on murine peritoneal macrophages
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of the Brazilian Chemical Society (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532009000300005 |
Resumo: | The 1,2,4-triazolyl-bridged polynuclear complexes [{PdCl2(µ-Htrz)}n] (1) and [{PdBr2(µ-Htrz)}n] (2) have been obtained in this work. Compound 1 is prepared by the displacement of acetonitrile from [PdCl2(MeCN)2] by 1,2,4-triazole (Htrz). Further addition of potassium bromide to the reaction medium afforded complex 2. The new complexes have been isolated, purified and characterized by means of elemental analysis, IR and UV-visible electronic spectroscopies and thermogravimetric (TG) curves. The experimental data suggested that, in both cases, the coordination of 1,2,4-Htrz takes place through the N(2) and N(4) atoms, bridging the palladium centers. The square-planar coordination polyhedron of palladium(II) is determined by two nitrogen atoms from the triazole ligands, while the other two coordination positions are occupied by the chloro (1) or bromo (2) ligands. TG curves indicated that the nature of the anionic ligand does not affect significantly the thermal stability of 1 and 2. The final products of the thermal decompositions were identified as metallic palladium by X-ray powder diffractometry. Preliminary tests involving the evaluation of the effects of compounds 1, 2 and Htrz on H2O2 and NO production in cultures of peritoneal macrophages from BALB/c mice were carried out in vitro. |
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Immunomodulatory effects of palladium(II) complexes of 1,2,4-triazole on murine peritoneal macrophagespalladium(II) complexes1,2,4-triazolemacrophagesnitric oxidehydrogen peroxideThe 1,2,4-triazolyl-bridged polynuclear complexes [{PdCl2(µ-Htrz)}n] (1) and [{PdBr2(µ-Htrz)}n] (2) have been obtained in this work. Compound 1 is prepared by the displacement of acetonitrile from [PdCl2(MeCN)2] by 1,2,4-triazole (Htrz). Further addition of potassium bromide to the reaction medium afforded complex 2. The new complexes have been isolated, purified and characterized by means of elemental analysis, IR and UV-visible electronic spectroscopies and thermogravimetric (TG) curves. The experimental data suggested that, in both cases, the coordination of 1,2,4-Htrz takes place through the N(2) and N(4) atoms, bridging the palladium centers. The square-planar coordination polyhedron of palladium(II) is determined by two nitrogen atoms from the triazole ligands, while the other two coordination positions are occupied by the chloro (1) or bromo (2) ligands. TG curves indicated that the nature of the anionic ligand does not affect significantly the thermal stability of 1 and 2. The final products of the thermal decompositions were identified as metallic palladium by X-ray powder diffractometry. Preliminary tests involving the evaluation of the effects of compounds 1, 2 and Htrz on H2O2 and NO production in cultures of peritoneal macrophages from BALB/c mice were carried out in vitro.Sociedade Brasileira de Química2009-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532009000300005Journal of the Brazilian Chemical Society v.20 n.3 2009reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532009000300005info:eu-repo/semantics/openAccessBego,Amadeu M.Frem,Regina C. G.Netto,Adelino V.G.Mauro,Antonio E.Ananias,Sandra R.Carlos,Iracilda Z.Rocha,Michelle C. daeng2009-05-25T00:00:00Zoai:scielo:S0103-50532009000300005Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2009-05-25T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
Immunomodulatory effects of palladium(II) complexes of 1,2,4-triazole on murine peritoneal macrophages |
title |
Immunomodulatory effects of palladium(II) complexes of 1,2,4-triazole on murine peritoneal macrophages |
spellingShingle |
Immunomodulatory effects of palladium(II) complexes of 1,2,4-triazole on murine peritoneal macrophages Bego,Amadeu M. palladium(II) complexes 1,2,4-triazole macrophages nitric oxide hydrogen peroxide |
title_short |
Immunomodulatory effects of palladium(II) complexes of 1,2,4-triazole on murine peritoneal macrophages |
title_full |
Immunomodulatory effects of palladium(II) complexes of 1,2,4-triazole on murine peritoneal macrophages |
title_fullStr |
Immunomodulatory effects of palladium(II) complexes of 1,2,4-triazole on murine peritoneal macrophages |
title_full_unstemmed |
Immunomodulatory effects of palladium(II) complexes of 1,2,4-triazole on murine peritoneal macrophages |
title_sort |
Immunomodulatory effects of palladium(II) complexes of 1,2,4-triazole on murine peritoneal macrophages |
author |
Bego,Amadeu M. |
author_facet |
Bego,Amadeu M. Frem,Regina C. G. Netto,Adelino V.G. Mauro,Antonio E. Ananias,Sandra R. Carlos,Iracilda Z. Rocha,Michelle C. da |
author_role |
author |
author2 |
Frem,Regina C. G. Netto,Adelino V.G. Mauro,Antonio E. Ananias,Sandra R. Carlos,Iracilda Z. Rocha,Michelle C. da |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Bego,Amadeu M. Frem,Regina C. G. Netto,Adelino V.G. Mauro,Antonio E. Ananias,Sandra R. Carlos,Iracilda Z. Rocha,Michelle C. da |
dc.subject.por.fl_str_mv |
palladium(II) complexes 1,2,4-triazole macrophages nitric oxide hydrogen peroxide |
topic |
palladium(II) complexes 1,2,4-triazole macrophages nitric oxide hydrogen peroxide |
description |
The 1,2,4-triazolyl-bridged polynuclear complexes [{PdCl2(µ-Htrz)}n] (1) and [{PdBr2(µ-Htrz)}n] (2) have been obtained in this work. Compound 1 is prepared by the displacement of acetonitrile from [PdCl2(MeCN)2] by 1,2,4-triazole (Htrz). Further addition of potassium bromide to the reaction medium afforded complex 2. The new complexes have been isolated, purified and characterized by means of elemental analysis, IR and UV-visible electronic spectroscopies and thermogravimetric (TG) curves. The experimental data suggested that, in both cases, the coordination of 1,2,4-Htrz takes place through the N(2) and N(4) atoms, bridging the palladium centers. The square-planar coordination polyhedron of palladium(II) is determined by two nitrogen atoms from the triazole ligands, while the other two coordination positions are occupied by the chloro (1) or bromo (2) ligands. TG curves indicated that the nature of the anionic ligand does not affect significantly the thermal stability of 1 and 2. The final products of the thermal decompositions were identified as metallic palladium by X-ray powder diffractometry. Preliminary tests involving the evaluation of the effects of compounds 1, 2 and Htrz on H2O2 and NO production in cultures of peritoneal macrophages from BALB/c mice were carried out in vitro. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532009000300005 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532009000300005 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0103-50532009000300005 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Journal of the Brazilian Chemical Society v.20 n.3 2009 reponame:Journal of the Brazilian Chemical Society (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Journal of the Brazilian Chemical Society (Online) |
collection |
Journal of the Brazilian Chemical Society (Online) |
repository.name.fl_str_mv |
Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
||office@jbcs.sbq.org.br |
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1750318169775407104 |