Immunomodulatory Effects of Palladium(II) Complexes of 1,2,4-Triazole on Murine Peritoneal Macrophages
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/S0103-50532009000300005 http://hdl.handle.net/11449/7335 |
Resumo: | The 1,2,4-triazolyl-bridged polynuclear complexes [{PdCl(2)(mu-Htrz)}(n)] (1) and [{PdBr(2)(mu-Htrz)}(n)] (2) have been obtained in this work. Compound 1 is prepared by the displacement of acetonitrile from [PdCl(2)(MeCN)(2)] by 1,2,4-triazole (Htrz). Further addition of potassium bromide to the reaction medium afforded complex 2. The new complexes have been isolated, purified and characterized by means of elemental analysis, IR and UV-visible electronic spectroscopies and thermogravimetric (TG) curves. The experimental data suggested that, in both cases, the coordination of 1,2,4-Htrz takes place through the N(2) and N(4) atoms, bridging the palladium centers. The square-planar coordination polyhedron of palladium(II) is determined by two nitrogen atoms from the triazole ligands, while the other two coordination positions are occupied by the chloro (1) or bromo (2) ligands. TG curves indicated that the nature of the anionic ligand does not affect significantly the thermal stability of 1 and 2. The final products of the thermal decompositions were identified as metallic palladium by X-ray powder diffractometry. Preliminary tests involving the evaluation of the effects of compounds 1, 2 and Htrz on H(2)O(2) and NO production in cultures of peritoneal macrophages from BALB/c mice were carried out in vitro. |
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Immunomodulatory Effects of Palladium(II) Complexes of 1,2,4-Triazole on Murine Peritoneal Macrophagespalladium(II) complexes1,2,4-triazolemacrophagesnitric oxidehydrogen peroxideThe 1,2,4-triazolyl-bridged polynuclear complexes [{PdCl(2)(mu-Htrz)}(n)] (1) and [{PdBr(2)(mu-Htrz)}(n)] (2) have been obtained in this work. Compound 1 is prepared by the displacement of acetonitrile from [PdCl(2)(MeCN)(2)] by 1,2,4-triazole (Htrz). Further addition of potassium bromide to the reaction medium afforded complex 2. The new complexes have been isolated, purified and characterized by means of elemental analysis, IR and UV-visible electronic spectroscopies and thermogravimetric (TG) curves. The experimental data suggested that, in both cases, the coordination of 1,2,4-Htrz takes place through the N(2) and N(4) atoms, bridging the palladium centers. The square-planar coordination polyhedron of palladium(II) is determined by two nitrogen atoms from the triazole ligands, while the other two coordination positions are occupied by the chloro (1) or bromo (2) ligands. TG curves indicated that the nature of the anionic ligand does not affect significantly the thermal stability of 1 and 2. The final products of the thermal decompositions were identified as metallic palladium by X-ray powder diffractometry. Preliminary tests involving the evaluation of the effects of compounds 1, 2 and Htrz on H(2)O(2) and NO production in cultures of peritoneal macrophages from BALB/c mice were carried out in vitro.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Univ Estadual Paulista, Inst Quim Araraquara, Dept Quim Geral & Inorgan, BR-14801970 Araraquara, SP, BrazilUniv Estadual Paulista, Fac Ciencias Farmaceut, Dept Anal Clin, BR-14801902 Araraquara, SP, BrazilUniv Estadual Paulista, Inst Quim Araraquara, Dept Quim Geral & Inorgan, BR-14801970 Araraquara, SP, BrazilUniv Estadual Paulista, Fac Ciencias Farmaceut, Dept Anal Clin, BR-14801902 Araraquara, SP, BrazilSoc Brasileira QuimicaUniversidade Estadual Paulista (Unesp)Bego, Amadeu Moura [UNESP]Frem, Regina Célia Galvão [UNESP]Netto, Adelino Vieira de Godoy [UNESP]Mauro, Antonio Eduardo [UNESP]Ananias, Sandra R. [UNESP]Carlos, Iracilda Z. [UNESP]da Rocha, Michelle C. [UNESP]2014-05-20T13:23:58Z2014-05-20T13:23:58Z2009-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article437-444http://dx.doi.org/10.1590/S0103-50532009000300005Journal of The Brazilian Chemical Society. São Paulo: Soc Brasileira Quimica, v. 20, n. 3, p. 437-444, 2009.0103-5053http://hdl.handle.net/11449/733510.1590/S0103-50532009000300005S0103-50532009000300005WOS:000266403300004S0103-50532009000300005.pdf330022397081444879276770536508190000-0002-0057-7964Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of the Brazilian Chemical Society1.4440,357info:eu-repo/semantics/openAccess2024-06-21T15:18:09Zoai:repositorio.unesp.br:11449/7335Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T13:50:49.474235Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Immunomodulatory Effects of Palladium(II) Complexes of 1,2,4-Triazole on Murine Peritoneal Macrophages |
title |
Immunomodulatory Effects of Palladium(II) Complexes of 1,2,4-Triazole on Murine Peritoneal Macrophages |
spellingShingle |
Immunomodulatory Effects of Palladium(II) Complexes of 1,2,4-Triazole on Murine Peritoneal Macrophages Bego, Amadeu Moura [UNESP] palladium(II) complexes 1,2,4-triazole macrophages nitric oxide hydrogen peroxide |
title_short |
Immunomodulatory Effects of Palladium(II) Complexes of 1,2,4-Triazole on Murine Peritoneal Macrophages |
title_full |
Immunomodulatory Effects of Palladium(II) Complexes of 1,2,4-Triazole on Murine Peritoneal Macrophages |
title_fullStr |
Immunomodulatory Effects of Palladium(II) Complexes of 1,2,4-Triazole on Murine Peritoneal Macrophages |
title_full_unstemmed |
Immunomodulatory Effects of Palladium(II) Complexes of 1,2,4-Triazole on Murine Peritoneal Macrophages |
title_sort |
Immunomodulatory Effects of Palladium(II) Complexes of 1,2,4-Triazole on Murine Peritoneal Macrophages |
author |
Bego, Amadeu Moura [UNESP] |
author_facet |
Bego, Amadeu Moura [UNESP] Frem, Regina Célia Galvão [UNESP] Netto, Adelino Vieira de Godoy [UNESP] Mauro, Antonio Eduardo [UNESP] Ananias, Sandra R. [UNESP] Carlos, Iracilda Z. [UNESP] da Rocha, Michelle C. [UNESP] |
author_role |
author |
author2 |
Frem, Regina Célia Galvão [UNESP] Netto, Adelino Vieira de Godoy [UNESP] Mauro, Antonio Eduardo [UNESP] Ananias, Sandra R. [UNESP] Carlos, Iracilda Z. [UNESP] da Rocha, Michelle C. [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Bego, Amadeu Moura [UNESP] Frem, Regina Célia Galvão [UNESP] Netto, Adelino Vieira de Godoy [UNESP] Mauro, Antonio Eduardo [UNESP] Ananias, Sandra R. [UNESP] Carlos, Iracilda Z. [UNESP] da Rocha, Michelle C. [UNESP] |
dc.subject.por.fl_str_mv |
palladium(II) complexes 1,2,4-triazole macrophages nitric oxide hydrogen peroxide |
topic |
palladium(II) complexes 1,2,4-triazole macrophages nitric oxide hydrogen peroxide |
description |
The 1,2,4-triazolyl-bridged polynuclear complexes [{PdCl(2)(mu-Htrz)}(n)] (1) and [{PdBr(2)(mu-Htrz)}(n)] (2) have been obtained in this work. Compound 1 is prepared by the displacement of acetonitrile from [PdCl(2)(MeCN)(2)] by 1,2,4-triazole (Htrz). Further addition of potassium bromide to the reaction medium afforded complex 2. The new complexes have been isolated, purified and characterized by means of elemental analysis, IR and UV-visible electronic spectroscopies and thermogravimetric (TG) curves. The experimental data suggested that, in both cases, the coordination of 1,2,4-Htrz takes place through the N(2) and N(4) atoms, bridging the palladium centers. The square-planar coordination polyhedron of palladium(II) is determined by two nitrogen atoms from the triazole ligands, while the other two coordination positions are occupied by the chloro (1) or bromo (2) ligands. TG curves indicated that the nature of the anionic ligand does not affect significantly the thermal stability of 1 and 2. The final products of the thermal decompositions were identified as metallic palladium by X-ray powder diffractometry. Preliminary tests involving the evaluation of the effects of compounds 1, 2 and Htrz on H(2)O(2) and NO production in cultures of peritoneal macrophages from BALB/c mice were carried out in vitro. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-01-01 2014-05-20T13:23:58Z 2014-05-20T13:23:58Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0103-50532009000300005 Journal of The Brazilian Chemical Society. São Paulo: Soc Brasileira Quimica, v. 20, n. 3, p. 437-444, 2009. 0103-5053 http://hdl.handle.net/11449/7335 10.1590/S0103-50532009000300005 S0103-50532009000300005 WOS:000266403300004 S0103-50532009000300005.pdf 3300223970814448 7927677053650819 0000-0002-0057-7964 |
url |
http://dx.doi.org/10.1590/S0103-50532009000300005 http://hdl.handle.net/11449/7335 |
identifier_str_mv |
Journal of The Brazilian Chemical Society. São Paulo: Soc Brasileira Quimica, v. 20, n. 3, p. 437-444, 2009. 0103-5053 10.1590/S0103-50532009000300005 S0103-50532009000300005 WOS:000266403300004 S0103-50532009000300005.pdf 3300223970814448 7927677053650819 0000-0002-0057-7964 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of the Brazilian Chemical Society 1.444 0,357 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
437-444 |
dc.publisher.none.fl_str_mv |
Soc Brasileira Quimica |
publisher.none.fl_str_mv |
Soc Brasileira Quimica |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1808128283845328896 |