Immunomodulatory Effects of Palladium(II) Complexes of 1,2,4-Triazole on Murine Peritoneal Macrophages

Detalhes bibliográficos
Autor(a) principal: Bego, Amadeu Moura [UNESP]
Data de Publicação: 2009
Outros Autores: Frem, Regina Célia Galvão [UNESP], Netto, Adelino Vieira de Godoy [UNESP], Mauro, Antonio Eduardo [UNESP], Ananias, Sandra R. [UNESP], Carlos, Iracilda Z. [UNESP], da Rocha, Michelle C. [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/S0103-50532009000300005
http://hdl.handle.net/11449/7335
Resumo: The 1,2,4-triazolyl-bridged polynuclear complexes [{PdCl(2)(mu-Htrz)}(n)] (1) and [{PdBr(2)(mu-Htrz)}(n)] (2) have been obtained in this work. Compound 1 is prepared by the displacement of acetonitrile from [PdCl(2)(MeCN)(2)] by 1,2,4-triazole (Htrz). Further addition of potassium bromide to the reaction medium afforded complex 2. The new complexes have been isolated, purified and characterized by means of elemental analysis, IR and UV-visible electronic spectroscopies and thermogravimetric (TG) curves. The experimental data suggested that, in both cases, the coordination of 1,2,4-Htrz takes place through the N(2) and N(4) atoms, bridging the palladium centers. The square-planar coordination polyhedron of palladium(II) is determined by two nitrogen atoms from the triazole ligands, while the other two coordination positions are occupied by the chloro (1) or bromo (2) ligands. TG curves indicated that the nature of the anionic ligand does not affect significantly the thermal stability of 1 and 2. The final products of the thermal decompositions were identified as metallic palladium by X-ray powder diffractometry. Preliminary tests involving the evaluation of the effects of compounds 1, 2 and Htrz on H(2)O(2) and NO production in cultures of peritoneal macrophages from BALB/c mice were carried out in vitro.
id UNSP_92fe9b1793a1d81921f608b94df132f6
oai_identifier_str oai:repositorio.unesp.br:11449/7335
network_acronym_str UNSP
network_name_str Repositório Institucional da UNESP
repository_id_str 2946
spelling Immunomodulatory Effects of Palladium(II) Complexes of 1,2,4-Triazole on Murine Peritoneal Macrophagespalladium(II) complexes1,2,4-triazolemacrophagesnitric oxidehydrogen peroxideThe 1,2,4-triazolyl-bridged polynuclear complexes [{PdCl(2)(mu-Htrz)}(n)] (1) and [{PdBr(2)(mu-Htrz)}(n)] (2) have been obtained in this work. Compound 1 is prepared by the displacement of acetonitrile from [PdCl(2)(MeCN)(2)] by 1,2,4-triazole (Htrz). Further addition of potassium bromide to the reaction medium afforded complex 2. The new complexes have been isolated, purified and characterized by means of elemental analysis, IR and UV-visible electronic spectroscopies and thermogravimetric (TG) curves. The experimental data suggested that, in both cases, the coordination of 1,2,4-Htrz takes place through the N(2) and N(4) atoms, bridging the palladium centers. The square-planar coordination polyhedron of palladium(II) is determined by two nitrogen atoms from the triazole ligands, while the other two coordination positions are occupied by the chloro (1) or bromo (2) ligands. TG curves indicated that the nature of the anionic ligand does not affect significantly the thermal stability of 1 and 2. The final products of the thermal decompositions were identified as metallic palladium by X-ray powder diffractometry. Preliminary tests involving the evaluation of the effects of compounds 1, 2 and Htrz on H(2)O(2) and NO production in cultures of peritoneal macrophages from BALB/c mice were carried out in vitro.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Univ Estadual Paulista, Inst Quim Araraquara, Dept Quim Geral & Inorgan, BR-14801970 Araraquara, SP, BrazilUniv Estadual Paulista, Fac Ciencias Farmaceut, Dept Anal Clin, BR-14801902 Araraquara, SP, BrazilUniv Estadual Paulista, Inst Quim Araraquara, Dept Quim Geral & Inorgan, BR-14801970 Araraquara, SP, BrazilUniv Estadual Paulista, Fac Ciencias Farmaceut, Dept Anal Clin, BR-14801902 Araraquara, SP, BrazilSoc Brasileira QuimicaUniversidade Estadual Paulista (Unesp)Bego, Amadeu Moura [UNESP]Frem, Regina Célia Galvão [UNESP]Netto, Adelino Vieira de Godoy [UNESP]Mauro, Antonio Eduardo [UNESP]Ananias, Sandra R. [UNESP]Carlos, Iracilda Z. [UNESP]da Rocha, Michelle C. [UNESP]2014-05-20T13:23:58Z2014-05-20T13:23:58Z2009-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article437-444http://dx.doi.org/10.1590/S0103-50532009000300005Journal of The Brazilian Chemical Society. São Paulo: Soc Brasileira Quimica, v. 20, n. 3, p. 437-444, 2009.0103-5053http://hdl.handle.net/11449/733510.1590/S0103-50532009000300005S0103-50532009000300005WOS:000266403300004S0103-50532009000300005.pdf330022397081444879276770536508190000-0002-0057-7964Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of the Brazilian Chemical Society1.4440,357info:eu-repo/semantics/openAccess2024-06-21T15:18:09Zoai:repositorio.unesp.br:11449/7335Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T13:50:49.474235Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Immunomodulatory Effects of Palladium(II) Complexes of 1,2,4-Triazole on Murine Peritoneal Macrophages
title Immunomodulatory Effects of Palladium(II) Complexes of 1,2,4-Triazole on Murine Peritoneal Macrophages
spellingShingle Immunomodulatory Effects of Palladium(II) Complexes of 1,2,4-Triazole on Murine Peritoneal Macrophages
Bego, Amadeu Moura [UNESP]
palladium(II) complexes
1,2,4-triazole
macrophages
nitric oxide
hydrogen peroxide
title_short Immunomodulatory Effects of Palladium(II) Complexes of 1,2,4-Triazole on Murine Peritoneal Macrophages
title_full Immunomodulatory Effects of Palladium(II) Complexes of 1,2,4-Triazole on Murine Peritoneal Macrophages
title_fullStr Immunomodulatory Effects of Palladium(II) Complexes of 1,2,4-Triazole on Murine Peritoneal Macrophages
title_full_unstemmed Immunomodulatory Effects of Palladium(II) Complexes of 1,2,4-Triazole on Murine Peritoneal Macrophages
title_sort Immunomodulatory Effects of Palladium(II) Complexes of 1,2,4-Triazole on Murine Peritoneal Macrophages
author Bego, Amadeu Moura [UNESP]
author_facet Bego, Amadeu Moura [UNESP]
Frem, Regina Célia Galvão [UNESP]
Netto, Adelino Vieira de Godoy [UNESP]
Mauro, Antonio Eduardo [UNESP]
Ananias, Sandra R. [UNESP]
Carlos, Iracilda Z. [UNESP]
da Rocha, Michelle C. [UNESP]
author_role author
author2 Frem, Regina Célia Galvão [UNESP]
Netto, Adelino Vieira de Godoy [UNESP]
Mauro, Antonio Eduardo [UNESP]
Ananias, Sandra R. [UNESP]
Carlos, Iracilda Z. [UNESP]
da Rocha, Michelle C. [UNESP]
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Bego, Amadeu Moura [UNESP]
Frem, Regina Célia Galvão [UNESP]
Netto, Adelino Vieira de Godoy [UNESP]
Mauro, Antonio Eduardo [UNESP]
Ananias, Sandra R. [UNESP]
Carlos, Iracilda Z. [UNESP]
da Rocha, Michelle C. [UNESP]
dc.subject.por.fl_str_mv palladium(II) complexes
1,2,4-triazole
macrophages
nitric oxide
hydrogen peroxide
topic palladium(II) complexes
1,2,4-triazole
macrophages
nitric oxide
hydrogen peroxide
description The 1,2,4-triazolyl-bridged polynuclear complexes [{PdCl(2)(mu-Htrz)}(n)] (1) and [{PdBr(2)(mu-Htrz)}(n)] (2) have been obtained in this work. Compound 1 is prepared by the displacement of acetonitrile from [PdCl(2)(MeCN)(2)] by 1,2,4-triazole (Htrz). Further addition of potassium bromide to the reaction medium afforded complex 2. The new complexes have been isolated, purified and characterized by means of elemental analysis, IR and UV-visible electronic spectroscopies and thermogravimetric (TG) curves. The experimental data suggested that, in both cases, the coordination of 1,2,4-Htrz takes place through the N(2) and N(4) atoms, bridging the palladium centers. The square-planar coordination polyhedron of palladium(II) is determined by two nitrogen atoms from the triazole ligands, while the other two coordination positions are occupied by the chloro (1) or bromo (2) ligands. TG curves indicated that the nature of the anionic ligand does not affect significantly the thermal stability of 1 and 2. The final products of the thermal decompositions were identified as metallic palladium by X-ray powder diffractometry. Preliminary tests involving the evaluation of the effects of compounds 1, 2 and Htrz on H(2)O(2) and NO production in cultures of peritoneal macrophages from BALB/c mice were carried out in vitro.
publishDate 2009
dc.date.none.fl_str_mv 2009-01-01
2014-05-20T13:23:58Z
2014-05-20T13:23:58Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0103-50532009000300005
Journal of The Brazilian Chemical Society. São Paulo: Soc Brasileira Quimica, v. 20, n. 3, p. 437-444, 2009.
0103-5053
http://hdl.handle.net/11449/7335
10.1590/S0103-50532009000300005
S0103-50532009000300005
WOS:000266403300004
S0103-50532009000300005.pdf
3300223970814448
7927677053650819
0000-0002-0057-7964
url http://dx.doi.org/10.1590/S0103-50532009000300005
http://hdl.handle.net/11449/7335
identifier_str_mv Journal of The Brazilian Chemical Society. São Paulo: Soc Brasileira Quimica, v. 20, n. 3, p. 437-444, 2009.
0103-5053
10.1590/S0103-50532009000300005
S0103-50532009000300005
WOS:000266403300004
S0103-50532009000300005.pdf
3300223970814448
7927677053650819
0000-0002-0057-7964
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of the Brazilian Chemical Society
1.444
0,357
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 437-444
dc.publisher.none.fl_str_mv Soc Brasileira Quimica
publisher.none.fl_str_mv Soc Brasileira Quimica
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128283845328896