Limonin Derivatives: Synthesis Using Methodology in Solution and Heterogeneous Medium and Evaluation of the Antimicrobial Activity

• Autor(a) principal: Tavares,Luciana C.
• Data de Publicação: 2016
• Outros Autores: Fernandes,Tanize S., Ilha,Vinicius, Neto,Alexandre T., Santos,Eveline W. dos, Burrow,Robert A., Duarte,Fábio A., Flores,Erico M. M., Silva,Ubiratan F., Mostardeiro,Marco A., Morel,Ademir F.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Journal of the Brazilian Chemical Society (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532016000100161
• topic: limonin derivatives; methodology in solution; heterogeneous medium; antimicrobial

We herein described the preparation of a novel series of limonin derivatives (modification in A-ring), which was synthesized efficiently using methodology in solution as well as in heterogeneous medium (K-10). In addition, we obtained derivatives by inserting the 1,2,3-triazole nucleus via click reaction and also prepared derivatives from reactions with limonin-7-oxime. All compounds were submitted to investigation of the antimicrobial activity against a collection of microorganisms. The results of the antimicrobial activity, in general, demonstrated that a relevant number of synthetic derivatives presented higher activity than the natural product.