Simultaneous HPTLC determination of nabumetone and paracetamol in combined tablet dosage form
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of the Brazilian Chemical Society (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532011000600010 |
Resumo: | A new simple high performance thin layer chromatographic method (HPTLC) for simultaneous determination of nabumetone and paracetamol in combined tablet dosage form was developed and validated. The separations were carried out on Merck aluminum plates precoated with silica gel 60 F254, using toluene:2-propanol:acetic acid (8:2:0.1, v/v/v) as mobile phase. Quantitative determination of bands was done by densitometric scanning at 236 nm. The calculated retention factors for nabumetone and paracetamol were 0.78 ± 0.03 and 0.32 ± 0.03, respectively. The method was validated with respect to linearity, accuracy, precision and robustness. The calibration curves showed to be linear over a range of 50-250 ng per band for both drugs. The method has been successfully applied for the analysis of drugs in pharmaceutical formulation. The percentages of assay (mean ± S.D.) were 99.89 ± 1.15 for nabumetone and 101.10 ± 0.71 for paracetamol, both of commercially available tablets. |
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Simultaneous HPTLC determination of nabumetone and paracetamol in combined tablet dosage formnabumetoneparacetamolhigh performance thin layer chromatography (HPTLC)tablet dosage formA new simple high performance thin layer chromatographic method (HPTLC) for simultaneous determination of nabumetone and paracetamol in combined tablet dosage form was developed and validated. The separations were carried out on Merck aluminum plates precoated with silica gel 60 F254, using toluene:2-propanol:acetic acid (8:2:0.1, v/v/v) as mobile phase. Quantitative determination of bands was done by densitometric scanning at 236 nm. The calculated retention factors for nabumetone and paracetamol were 0.78 ± 0.03 and 0.32 ± 0.03, respectively. The method was validated with respect to linearity, accuracy, precision and robustness. The calibration curves showed to be linear over a range of 50-250 ng per band for both drugs. The method has been successfully applied for the analysis of drugs in pharmaceutical formulation. The percentages of assay (mean ± S.D.) were 99.89 ± 1.15 for nabumetone and 101.10 ± 0.71 for paracetamol, both of commercially available tablets.Sociedade Brasileira de Química2011-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532011000600010Journal of the Brazilian Chemical Society v.22 n.6 2011reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532011000600010info:eu-repo/semantics/openAccessGandhi,Santosh V.Ranher,Sandeep S.Deshpande,Padmanabh B.Shah,Dixit K.eng2011-06-10T00:00:00Zoai:scielo:S0103-50532011000600010Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2011-06-10T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
Simultaneous HPTLC determination of nabumetone and paracetamol in combined tablet dosage form |
title |
Simultaneous HPTLC determination of nabumetone and paracetamol in combined tablet dosage form |
spellingShingle |
Simultaneous HPTLC determination of nabumetone and paracetamol in combined tablet dosage form Gandhi,Santosh V. nabumetone paracetamol high performance thin layer chromatography (HPTLC) tablet dosage form |
title_short |
Simultaneous HPTLC determination of nabumetone and paracetamol in combined tablet dosage form |
title_full |
Simultaneous HPTLC determination of nabumetone and paracetamol in combined tablet dosage form |
title_fullStr |
Simultaneous HPTLC determination of nabumetone and paracetamol in combined tablet dosage form |
title_full_unstemmed |
Simultaneous HPTLC determination of nabumetone and paracetamol in combined tablet dosage form |
title_sort |
Simultaneous HPTLC determination of nabumetone and paracetamol in combined tablet dosage form |
author |
Gandhi,Santosh V. |
author_facet |
Gandhi,Santosh V. Ranher,Sandeep S. Deshpande,Padmanabh B. Shah,Dixit K. |
author_role |
author |
author2 |
Ranher,Sandeep S. Deshpande,Padmanabh B. Shah,Dixit K. |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Gandhi,Santosh V. Ranher,Sandeep S. Deshpande,Padmanabh B. Shah,Dixit K. |
dc.subject.por.fl_str_mv |
nabumetone paracetamol high performance thin layer chromatography (HPTLC) tablet dosage form |
topic |
nabumetone paracetamol high performance thin layer chromatography (HPTLC) tablet dosage form |
description |
A new simple high performance thin layer chromatographic method (HPTLC) for simultaneous determination of nabumetone and paracetamol in combined tablet dosage form was developed and validated. The separations were carried out on Merck aluminum plates precoated with silica gel 60 F254, using toluene:2-propanol:acetic acid (8:2:0.1, v/v/v) as mobile phase. Quantitative determination of bands was done by densitometric scanning at 236 nm. The calculated retention factors for nabumetone and paracetamol were 0.78 ± 0.03 and 0.32 ± 0.03, respectively. The method was validated with respect to linearity, accuracy, precision and robustness. The calibration curves showed to be linear over a range of 50-250 ng per band for both drugs. The method has been successfully applied for the analysis of drugs in pharmaceutical formulation. The percentages of assay (mean ± S.D.) were 99.89 ± 1.15 for nabumetone and 101.10 ± 0.71 for paracetamol, both of commercially available tablets. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532011000600010 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532011000600010 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0103-50532011000600010 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Journal of the Brazilian Chemical Society v.22 n.6 2011 reponame:Journal of the Brazilian Chemical Society (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Journal of the Brazilian Chemical Society (Online) |
collection |
Journal of the Brazilian Chemical Society (Online) |
repository.name.fl_str_mv |
Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
||office@jbcs.sbq.org.br |
_version_ |
1750318172290940928 |