Chemical Constituents of the Seeds of Raphanus sativus and their Biological Activity
Autor(a) principal: | |
---|---|
Data de Publicação: | 2015 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of the Brazilian Chemical Society (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532015001102307 |
Resumo: | As part of our ongoing search for bioactive constituents of natural Korean medicinal resources, a bioassay-guided fractionation and chemical investigation of the MeOH extract of Raphanus sativus (Brassicaceae) seeds resulted in the isolation and identification of fifteen compounds, including a new phenolic compound. The structure of the new compound was determined by extensive spectroscopic analysis and the Mosher's method. One of the compounds has been recently reported as a synthetic product. Some compounds showed moderate antiproliferative activities against the tumor cell lines A549, SK-OV-3, SK-MEL-2, and HCT-15 with IC50 values in the range of 5.62 to 28.88 μM. Moreover, the anti-neuroinflammatory activities of the isolates were determined by measuring the nitric oxide (NO) levels in the medium using murine microglia BV-2 cells. With exception of one specific compound, all the others inhibited the lipopolysaccharide (LPS)-stimulated NO production (IC50 values < 200 μM). |
id |
SBQ-2_2cb71903ea9c03b75622bf82bee27dfc |
---|---|
oai_identifier_str |
oai:scielo:S0103-50532015001102307 |
network_acronym_str |
SBQ-2 |
network_name_str |
Journal of the Brazilian Chemical Society (Online) |
repository_id_str |
|
spelling |
Chemical Constituents of the Seeds of Raphanus sativus and their Biological ActivityRaphanus sativusBrassicaceaecytotoxicityanti-inflammationMosher’s methodAs part of our ongoing search for bioactive constituents of natural Korean medicinal resources, a bioassay-guided fractionation and chemical investigation of the MeOH extract of Raphanus sativus (Brassicaceae) seeds resulted in the isolation and identification of fifteen compounds, including a new phenolic compound. The structure of the new compound was determined by extensive spectroscopic analysis and the Mosher's method. One of the compounds has been recently reported as a synthetic product. Some compounds showed moderate antiproliferative activities against the tumor cell lines A549, SK-OV-3, SK-MEL-2, and HCT-15 with IC50 values in the range of 5.62 to 28.88 μM. Moreover, the anti-neuroinflammatory activities of the isolates were determined by measuring the nitric oxide (NO) levels in the medium using murine microglia BV-2 cells. With exception of one specific compound, all the others inhibited the lipopolysaccharide (LPS)-stimulated NO production (IC50 values < 200 μM).Sociedade Brasileira de Química2015-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532015001102307Journal of the Brazilian Chemical Society v.26 n.11 2015reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.5935/0103-5053.20150222info:eu-repo/semantics/openAccessKim,Ki HyunMoon,EunjungLee,Seoung RakPark,Kyoung JinKim,Sun YeouChoi,Sang UnLee,Kang Roeng2015-11-24T00:00:00Zoai:scielo:S0103-50532015001102307Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2015-11-24T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
Chemical Constituents of the Seeds of Raphanus sativus and their Biological Activity |
title |
Chemical Constituents of the Seeds of Raphanus sativus and their Biological Activity |
spellingShingle |
Chemical Constituents of the Seeds of Raphanus sativus and their Biological Activity Kim,Ki Hyun Raphanus sativus Brassicaceae cytotoxicity anti-inflammation Mosher’s method |
title_short |
Chemical Constituents of the Seeds of Raphanus sativus and their Biological Activity |
title_full |
Chemical Constituents of the Seeds of Raphanus sativus and their Biological Activity |
title_fullStr |
Chemical Constituents of the Seeds of Raphanus sativus and their Biological Activity |
title_full_unstemmed |
Chemical Constituents of the Seeds of Raphanus sativus and their Biological Activity |
title_sort |
Chemical Constituents of the Seeds of Raphanus sativus and their Biological Activity |
author |
Kim,Ki Hyun |
author_facet |
Kim,Ki Hyun Moon,Eunjung Lee,Seoung Rak Park,Kyoung Jin Kim,Sun Yeou Choi,Sang Un Lee,Kang Ro |
author_role |
author |
author2 |
Moon,Eunjung Lee,Seoung Rak Park,Kyoung Jin Kim,Sun Yeou Choi,Sang Un Lee,Kang Ro |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Kim,Ki Hyun Moon,Eunjung Lee,Seoung Rak Park,Kyoung Jin Kim,Sun Yeou Choi,Sang Un Lee,Kang Ro |
dc.subject.por.fl_str_mv |
Raphanus sativus Brassicaceae cytotoxicity anti-inflammation Mosher’s method |
topic |
Raphanus sativus Brassicaceae cytotoxicity anti-inflammation Mosher’s method |
description |
As part of our ongoing search for bioactive constituents of natural Korean medicinal resources, a bioassay-guided fractionation and chemical investigation of the MeOH extract of Raphanus sativus (Brassicaceae) seeds resulted in the isolation and identification of fifteen compounds, including a new phenolic compound. The structure of the new compound was determined by extensive spectroscopic analysis and the Mosher's method. One of the compounds has been recently reported as a synthetic product. Some compounds showed moderate antiproliferative activities against the tumor cell lines A549, SK-OV-3, SK-MEL-2, and HCT-15 with IC50 values in the range of 5.62 to 28.88 μM. Moreover, the anti-neuroinflammatory activities of the isolates were determined by measuring the nitric oxide (NO) levels in the medium using murine microglia BV-2 cells. With exception of one specific compound, all the others inhibited the lipopolysaccharide (LPS)-stimulated NO production (IC50 values < 200 μM). |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-11-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532015001102307 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532015001102307 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.5935/0103-5053.20150222 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Journal of the Brazilian Chemical Society v.26 n.11 2015 reponame:Journal of the Brazilian Chemical Society (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Journal of the Brazilian Chemical Society (Online) |
collection |
Journal of the Brazilian Chemical Society (Online) |
repository.name.fl_str_mv |
Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
||office@jbcs.sbq.org.br |
_version_ |
1750318177840005120 |