Stability indicating square-wave stripping voltammetric method for determination of gatifloxacin in pharmaceutical formulation and human blood

Detalhes bibliográficos
Autor(a) principal: El-Desoky,Hanaa Salah
Data de Publicação: 2009
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532009001000004
Resumo: A fully validated, sensitive and precise stability-indicating square-wave adsorptive cathodic stripping voltammetric method has been developed for determination of gatifloxacin in the bulk form, pharmaceutical formulation, and in spiked human serum and real plasma samples. The achieved detection limits of gatifloxacin in the bulk form and human serum were 1.5 × 10-9 and 2.2 × 10-9 mol L-1, respectively. The described method was applied successfully for determination of gatifloxacin in formulation and human biological samples without extraction prior to the analysis. No significant interferences from common excipients, some common metal ions, organic species, co-administrated drugs and from the acid-induced degradation products were obtained during analysis of gatifloxacin in the various analyzed samples. Besides, pharmacokinetic parameters of gatifloxacin in plasma of healthy volunteers following the administration of an oral single dose (400 mg gatifloxacin) were also estimated by means of the described stripping voltammetric method.
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spelling Stability indicating square-wave stripping voltammetric method for determination of gatifloxacin in pharmaceutical formulation and human bloodgatifloxacintequin tabletshuman bloodstripping voltammetrypharmacokinetic parametersA fully validated, sensitive and precise stability-indicating square-wave adsorptive cathodic stripping voltammetric method has been developed for determination of gatifloxacin in the bulk form, pharmaceutical formulation, and in spiked human serum and real plasma samples. The achieved detection limits of gatifloxacin in the bulk form and human serum were 1.5 × 10-9 and 2.2 × 10-9 mol L-1, respectively. The described method was applied successfully for determination of gatifloxacin in formulation and human biological samples without extraction prior to the analysis. No significant interferences from common excipients, some common metal ions, organic species, co-administrated drugs and from the acid-induced degradation products were obtained during analysis of gatifloxacin in the various analyzed samples. Besides, pharmacokinetic parameters of gatifloxacin in plasma of healthy volunteers following the administration of an oral single dose (400 mg gatifloxacin) were also estimated by means of the described stripping voltammetric method.Sociedade Brasileira de Química2009-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532009001000004Journal of the Brazilian Chemical Society v.20 n.10 2009reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532009001000004info:eu-repo/semantics/openAccessEl-Desoky,Hanaa Salaheng2011-10-14T00:00:00Zoai:scielo:S0103-50532009001000004Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2011-10-14T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Stability indicating square-wave stripping voltammetric method for determination of gatifloxacin in pharmaceutical formulation and human blood
title Stability indicating square-wave stripping voltammetric method for determination of gatifloxacin in pharmaceutical formulation and human blood
spellingShingle Stability indicating square-wave stripping voltammetric method for determination of gatifloxacin in pharmaceutical formulation and human blood
El-Desoky,Hanaa Salah
gatifloxacin
tequin tablets
human blood
stripping voltammetry
pharmacokinetic parameters
title_short Stability indicating square-wave stripping voltammetric method for determination of gatifloxacin in pharmaceutical formulation and human blood
title_full Stability indicating square-wave stripping voltammetric method for determination of gatifloxacin in pharmaceutical formulation and human blood
title_fullStr Stability indicating square-wave stripping voltammetric method for determination of gatifloxacin in pharmaceutical formulation and human blood
title_full_unstemmed Stability indicating square-wave stripping voltammetric method for determination of gatifloxacin in pharmaceutical formulation and human blood
title_sort Stability indicating square-wave stripping voltammetric method for determination of gatifloxacin in pharmaceutical formulation and human blood
author El-Desoky,Hanaa Salah
author_facet El-Desoky,Hanaa Salah
author_role author
dc.contributor.author.fl_str_mv El-Desoky,Hanaa Salah
dc.subject.por.fl_str_mv gatifloxacin
tequin tablets
human blood
stripping voltammetry
pharmacokinetic parameters
topic gatifloxacin
tequin tablets
human blood
stripping voltammetry
pharmacokinetic parameters
description A fully validated, sensitive and precise stability-indicating square-wave adsorptive cathodic stripping voltammetric method has been developed for determination of gatifloxacin in the bulk form, pharmaceutical formulation, and in spiked human serum and real plasma samples. The achieved detection limits of gatifloxacin in the bulk form and human serum were 1.5 × 10-9 and 2.2 × 10-9 mol L-1, respectively. The described method was applied successfully for determination of gatifloxacin in formulation and human biological samples without extraction prior to the analysis. No significant interferences from common excipients, some common metal ions, organic species, co-administrated drugs and from the acid-induced degradation products were obtained during analysis of gatifloxacin in the various analyzed samples. Besides, pharmacokinetic parameters of gatifloxacin in plasma of healthy volunteers following the administration of an oral single dose (400 mg gatifloxacin) were also estimated by means of the described stripping voltammetric method.
publishDate 2009
dc.date.none.fl_str_mv 2009-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532009001000004
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532009001000004
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-50532009001000004
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.20 n.10 2009
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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