Application of a New Strategy of Validation Based on "β,γ-Content Tolerance Interval" for Checking the Chiral Chromatography Method for Quantification of the Chiral Impurity of Levofloxacin

Detalhes bibliográficos
Autor(a) principal: Bouchafra,Houda
Data de Publicação: 2016
Outros Autores: El karbane,Miloud, Azougagh,Mohamed, Jhilal,Fayssal, Sosse,Saad Alawi, El hadrami,EL Mestafa, Saffaj,Taoufiq, Ihssane,Bouchaîb
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532016000300500
Resumo: A simple and accurate chiral high performance liquid chromatography (HPLC) method was developed for determination of Levofloxacin and its chiral impurity (R)-enantiomer. The chiral impurity Levofloxacin separation method was optimized by Box-Behnken design and validated by an innovative analytical approach recently developed in our laboratory. This last approach as well as uncertainty estimation consists of building a graphical decision-making tool, based on the β,γ-content tolerance interval, called the uncertainty profile. The proposal approach applied to the optimized chiral separation method of Levofloxacin shows its fitness.
id SBQ-2_44f89269f27156704d94da821eb67adc
oai_identifier_str oai:scielo:S0103-50532016000300500
network_acronym_str SBQ-2
network_name_str Journal of the Brazilian Chemical Society (Online)
repository_id_str
spelling Application of a New Strategy of Validation Based on "β,γ-Content Tolerance Interval" for Checking the Chiral Chromatography Method for Quantification of the Chiral Impurity of LevofloxacinLevofloxacinexperimental designuncertainty profileβ,γ-content tolerance intervalmeasurement uncertaintyA simple and accurate chiral high performance liquid chromatography (HPLC) method was developed for determination of Levofloxacin and its chiral impurity (R)-enantiomer. The chiral impurity Levofloxacin separation method was optimized by Box-Behnken design and validated by an innovative analytical approach recently developed in our laboratory. This last approach as well as uncertainty estimation consists of building a graphical decision-making tool, based on the β,γ-content tolerance interval, called the uncertainty profile. The proposal approach applied to the optimized chiral separation method of Levofloxacin shows its fitness.Sociedade Brasileira de Química2016-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532016000300500Journal of the Brazilian Chemical Society v.27 n.3 2016reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.5935/0103-5053.20150277info:eu-repo/semantics/openAccessBouchafra,HoudaEl karbane,MiloudAzougagh,MohamedJhilal,FayssalSosse,Saad AlawiEl hadrami,EL MestafaSaffaj,TaoufiqIhssane,Bouchaîbeng2016-03-10T00:00:00Zoai:scielo:S0103-50532016000300500Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2016-03-10T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Application of a New Strategy of Validation Based on "β,γ-Content Tolerance Interval" for Checking the Chiral Chromatography Method for Quantification of the Chiral Impurity of Levofloxacin
title Application of a New Strategy of Validation Based on "β,γ-Content Tolerance Interval" for Checking the Chiral Chromatography Method for Quantification of the Chiral Impurity of Levofloxacin
spellingShingle Application of a New Strategy of Validation Based on "β,γ-Content Tolerance Interval" for Checking the Chiral Chromatography Method for Quantification of the Chiral Impurity of Levofloxacin
Bouchafra,Houda
Levofloxacin
experimental design
uncertainty profile
β,γ-content tolerance interval
measurement uncertainty
title_short Application of a New Strategy of Validation Based on "β,γ-Content Tolerance Interval" for Checking the Chiral Chromatography Method for Quantification of the Chiral Impurity of Levofloxacin
title_full Application of a New Strategy of Validation Based on "β,γ-Content Tolerance Interval" for Checking the Chiral Chromatography Method for Quantification of the Chiral Impurity of Levofloxacin
title_fullStr Application of a New Strategy of Validation Based on "β,γ-Content Tolerance Interval" for Checking the Chiral Chromatography Method for Quantification of the Chiral Impurity of Levofloxacin
title_full_unstemmed Application of a New Strategy of Validation Based on "β,γ-Content Tolerance Interval" for Checking the Chiral Chromatography Method for Quantification of the Chiral Impurity of Levofloxacin
title_sort Application of a New Strategy of Validation Based on "β,γ-Content Tolerance Interval" for Checking the Chiral Chromatography Method for Quantification of the Chiral Impurity of Levofloxacin
author Bouchafra,Houda
author_facet Bouchafra,Houda
El karbane,Miloud
Azougagh,Mohamed
Jhilal,Fayssal
Sosse,Saad Alawi
El hadrami,EL Mestafa
Saffaj,Taoufiq
Ihssane,Bouchaîb
author_role author
author2 El karbane,Miloud
Azougagh,Mohamed
Jhilal,Fayssal
Sosse,Saad Alawi
El hadrami,EL Mestafa
Saffaj,Taoufiq
Ihssane,Bouchaîb
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Bouchafra,Houda
El karbane,Miloud
Azougagh,Mohamed
Jhilal,Fayssal
Sosse,Saad Alawi
El hadrami,EL Mestafa
Saffaj,Taoufiq
Ihssane,Bouchaîb
dc.subject.por.fl_str_mv Levofloxacin
experimental design
uncertainty profile
β,γ-content tolerance interval
measurement uncertainty
topic Levofloxacin
experimental design
uncertainty profile
β,γ-content tolerance interval
measurement uncertainty
description A simple and accurate chiral high performance liquid chromatography (HPLC) method was developed for determination of Levofloxacin and its chiral impurity (R)-enantiomer. The chiral impurity Levofloxacin separation method was optimized by Box-Behnken design and validated by an innovative analytical approach recently developed in our laboratory. This last approach as well as uncertainty estimation consists of building a graphical decision-making tool, based on the β,γ-content tolerance interval, called the uncertainty profile. The proposal approach applied to the optimized chiral separation method of Levofloxacin shows its fitness.
publishDate 2016
dc.date.none.fl_str_mv 2016-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532016000300500
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532016000300500
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/0103-5053.20150277
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.27 n.3 2016
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
_version_ 1750318178251046912

Registros relacionados