Novel method for determination of trace amounts of citalopram in tablets by fast fourier continuous cyclic voltammetry at au microelectrode in flowing solutions
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of the Brazilian Chemical Society (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532007000100027 |
Resumo: | In this work, fast Fourier transform continuous cyclic voltammetric technique for the monitoring of ultra trace amounts of citalopram in a flow-injection system has been presented. The potential waveform, consisting of the potential steps for cleaning, stripping and potential ramp, was continuously applied on an Au disk microelectrode (with a 12.5 µm in radius). The proposed detection method has some advantages, the greatest of which are as follows: first, it is no more necessary to remove oxygen from the analyte solution and second, this is a very fast and appropriate technique for determination of the drug compound in a wide variety of chromatographic analysis methods. The method was linear over the concentration range of 7 - 116 pg mL-1 (r = 0.9960) with a limit of detection and quantitation 2.3 and 7 pg mL-1, respectively. The method has the requisite accuracy, sensitivity, precision and selectivity to assay citalopram in tablets. The influences of pH of eluent, accumulation potential, sweep rate, and accumulation time on the determination of the citalopram were considered. The proposed method was applied to the determination of citalopram in a pharmaceutical preparation. |
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Novel method for determination of trace amounts of citalopram in tablets by fast fourier continuous cyclic voltammetry at au microelectrode in flowing solutionscitalopramfast Fourier transformationflow injection analysisUltra microelectrodecyclic voltammetryIn this work, fast Fourier transform continuous cyclic voltammetric technique for the monitoring of ultra trace amounts of citalopram in a flow-injection system has been presented. The potential waveform, consisting of the potential steps for cleaning, stripping and potential ramp, was continuously applied on an Au disk microelectrode (with a 12.5 µm in radius). The proposed detection method has some advantages, the greatest of which are as follows: first, it is no more necessary to remove oxygen from the analyte solution and second, this is a very fast and appropriate technique for determination of the drug compound in a wide variety of chromatographic analysis methods. The method was linear over the concentration range of 7 - 116 pg mL-1 (r = 0.9960) with a limit of detection and quantitation 2.3 and 7 pg mL-1, respectively. The method has the requisite accuracy, sensitivity, precision and selectivity to assay citalopram in tablets. The influences of pH of eluent, accumulation potential, sweep rate, and accumulation time on the determination of the citalopram were considered. The proposed method was applied to the determination of citalopram in a pharmaceutical preparation.Sociedade Brasileira de Química2007-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532007000100027Journal of the Brazilian Chemical Society v.18 n.1 2007reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532007000100027info:eu-repo/semantics/openAccessNorouzi,ParvizDaneshgar,ParandisGanjali,Mohammad RezaMoosavi-Movahedi,Aliakbareng2007-03-23T00:00:00Zoai:scielo:S0103-50532007000100027Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2007-03-23T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
Novel method for determination of trace amounts of citalopram in tablets by fast fourier continuous cyclic voltammetry at au microelectrode in flowing solutions |
title |
Novel method for determination of trace amounts of citalopram in tablets by fast fourier continuous cyclic voltammetry at au microelectrode in flowing solutions |
spellingShingle |
Novel method for determination of trace amounts of citalopram in tablets by fast fourier continuous cyclic voltammetry at au microelectrode in flowing solutions Norouzi,Parviz citalopram fast Fourier transformation flow injection analysis Ultra microelectrode cyclic voltammetry |
title_short |
Novel method for determination of trace amounts of citalopram in tablets by fast fourier continuous cyclic voltammetry at au microelectrode in flowing solutions |
title_full |
Novel method for determination of trace amounts of citalopram in tablets by fast fourier continuous cyclic voltammetry at au microelectrode in flowing solutions |
title_fullStr |
Novel method for determination of trace amounts of citalopram in tablets by fast fourier continuous cyclic voltammetry at au microelectrode in flowing solutions |
title_full_unstemmed |
Novel method for determination of trace amounts of citalopram in tablets by fast fourier continuous cyclic voltammetry at au microelectrode in flowing solutions |
title_sort |
Novel method for determination of trace amounts of citalopram in tablets by fast fourier continuous cyclic voltammetry at au microelectrode in flowing solutions |
author |
Norouzi,Parviz |
author_facet |
Norouzi,Parviz Daneshgar,Parandis Ganjali,Mohammad Reza Moosavi-Movahedi,Aliakbar |
author_role |
author |
author2 |
Daneshgar,Parandis Ganjali,Mohammad Reza Moosavi-Movahedi,Aliakbar |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Norouzi,Parviz Daneshgar,Parandis Ganjali,Mohammad Reza Moosavi-Movahedi,Aliakbar |
dc.subject.por.fl_str_mv |
citalopram fast Fourier transformation flow injection analysis Ultra microelectrode cyclic voltammetry |
topic |
citalopram fast Fourier transformation flow injection analysis Ultra microelectrode cyclic voltammetry |
description |
In this work, fast Fourier transform continuous cyclic voltammetric technique for the monitoring of ultra trace amounts of citalopram in a flow-injection system has been presented. The potential waveform, consisting of the potential steps for cleaning, stripping and potential ramp, was continuously applied on an Au disk microelectrode (with a 12.5 µm in radius). The proposed detection method has some advantages, the greatest of which are as follows: first, it is no more necessary to remove oxygen from the analyte solution and second, this is a very fast and appropriate technique for determination of the drug compound in a wide variety of chromatographic analysis methods. The method was linear over the concentration range of 7 - 116 pg mL-1 (r = 0.9960) with a limit of detection and quantitation 2.3 and 7 pg mL-1, respectively. The method has the requisite accuracy, sensitivity, precision and selectivity to assay citalopram in tablets. The influences of pH of eluent, accumulation potential, sweep rate, and accumulation time on the determination of the citalopram were considered. The proposed method was applied to the determination of citalopram in a pharmaceutical preparation. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532007000100027 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532007000100027 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0103-50532007000100027 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Journal of the Brazilian Chemical Society v.18 n.1 2007 reponame:Journal of the Brazilian Chemical Society (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Journal of the Brazilian Chemical Society (Online) |
collection |
Journal of the Brazilian Chemical Society (Online) |
repository.name.fl_str_mv |
Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
||office@jbcs.sbq.org.br |
_version_ |
1750318167793598464 |