2"-Ethyl-furanoflavone derivatives from the stems of Cassia fistula and their cytotoxicity

Detalhes bibliográficos
Autor(a) principal: Gao,Xue-Mei
Data de Publicação: 2013
Outros Autores: Shen,Yan-Qiong, Huang,Xiang-Zhong, Yang,Li-Ying, Shu,Li-Dan, Hu,Qiu-Fen, Li,Gan-Peng
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532013000400023
Resumo: Two new 2"-ethyl-furanoflavones named fistulaflavones A and B together with six known furanoflavones were isolated from the stems of Cassia fistula. The structures were elucidated by spectroscopic methods including extensive 1D, 2D NMR and high resolution electrospray ionization mass spectrometry (HRESIMS) techniques, and comparison with literature data. All the compounds were evaluated for their cytotoxicity against five human tumor cell lines. One of the compounds showed potent cytotoxicity against SHSY5Y and MCF7 cells with IC50 values of 2.7 and 2.6 µmol L-1, respectively.
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spelling 2"-Ethyl-furanoflavone derivatives from the stems of Cassia fistula and their cytotoxicityCassia fistula2"-ethyl-furanoflavonesfuranoflavonescytotoxicityTwo new 2"-ethyl-furanoflavones named fistulaflavones A and B together with six known furanoflavones were isolated from the stems of Cassia fistula. The structures were elucidated by spectroscopic methods including extensive 1D, 2D NMR and high resolution electrospray ionization mass spectrometry (HRESIMS) techniques, and comparison with literature data. All the compounds were evaluated for their cytotoxicity against five human tumor cell lines. One of the compounds showed potent cytotoxicity against SHSY5Y and MCF7 cells with IC50 values of 2.7 and 2.6 µmol L-1, respectively.Sociedade Brasileira de Química2013-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532013000400023Journal of the Brazilian Chemical Society v.24 n.4 2013reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.5935/0103-5053.20130091info:eu-repo/semantics/openAccessGao,Xue-MeiShen,Yan-QiongHuang,Xiang-ZhongYang,Li-YingShu,Li-DanHu,Qiu-FenLi,Gan-Pengeng2013-05-20T00:00:00Zoai:scielo:S0103-50532013000400023Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2013-05-20T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv 2"-Ethyl-furanoflavone derivatives from the stems of Cassia fistula and their cytotoxicity
title 2"-Ethyl-furanoflavone derivatives from the stems of Cassia fistula and their cytotoxicity
spellingShingle 2"-Ethyl-furanoflavone derivatives from the stems of Cassia fistula and their cytotoxicity
Gao,Xue-Mei
Cassia fistula
2"-ethyl-furanoflavones
furanoflavones
cytotoxicity
title_short 2"-Ethyl-furanoflavone derivatives from the stems of Cassia fistula and their cytotoxicity
title_full 2"-Ethyl-furanoflavone derivatives from the stems of Cassia fistula and their cytotoxicity
title_fullStr 2"-Ethyl-furanoflavone derivatives from the stems of Cassia fistula and their cytotoxicity
title_full_unstemmed 2"-Ethyl-furanoflavone derivatives from the stems of Cassia fistula and their cytotoxicity
title_sort 2"-Ethyl-furanoflavone derivatives from the stems of Cassia fistula and their cytotoxicity
author Gao,Xue-Mei
author_facet Gao,Xue-Mei
Shen,Yan-Qiong
Huang,Xiang-Zhong
Yang,Li-Ying
Shu,Li-Dan
Hu,Qiu-Fen
Li,Gan-Peng
author_role author
author2 Shen,Yan-Qiong
Huang,Xiang-Zhong
Yang,Li-Ying
Shu,Li-Dan
Hu,Qiu-Fen
Li,Gan-Peng
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Gao,Xue-Mei
Shen,Yan-Qiong
Huang,Xiang-Zhong
Yang,Li-Ying
Shu,Li-Dan
Hu,Qiu-Fen
Li,Gan-Peng
dc.subject.por.fl_str_mv Cassia fistula
2"-ethyl-furanoflavones
furanoflavones
cytotoxicity
topic Cassia fistula
2"-ethyl-furanoflavones
furanoflavones
cytotoxicity
description Two new 2"-ethyl-furanoflavones named fistulaflavones A and B together with six known furanoflavones were isolated from the stems of Cassia fistula. The structures were elucidated by spectroscopic methods including extensive 1D, 2D NMR and high resolution electrospray ionization mass spectrometry (HRESIMS) techniques, and comparison with literature data. All the compounds were evaluated for their cytotoxicity against five human tumor cell lines. One of the compounds showed potent cytotoxicity against SHSY5Y and MCF7 cells with IC50 values of 2.7 and 2.6 µmol L-1, respectively.
publishDate 2013
dc.date.none.fl_str_mv 2013-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532013000400023
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532013000400023
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/0103-5053.20130091
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.24 n.4 2013
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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