Electrochemical oxidation of chlorhexidine and its amperometric determination by flow-injection analysis

Detalhes bibliográficos
Autor(a) principal: Lima,Ana Paula de
Data de Publicação: 2014
Outros Autores: Stefano,Jessica S., Montes,Rodrigo H. O., Cunha,Rafael R., Silva,Luiz A. J., Richter,Eduardo M., Muñoz,Rodrigo A. A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532014000300006
Resumo: The electrochemical oxidation of chlorhexidine is investigated for the first time and its amperometric determination using a flow-injection analysis (FIA) system is demonstrated. An oxidation peak was observed at around 1.3 V in a 0.1 mol L-1 HClO4 solution at a glassy-carbon electrode. The mechanism of the electrochemical oxidation of chlorhexidine is pH-dependent and involves a single-electron transfer possibly via radical cation formation. The FIA parameters were optimized and a detection limit of 0.3 µmol L-1 was obtained. The proposed method was applied in mouth rinses and skin disinfectants samples and compared with high-performance liquid chromatography.
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spelling Electrochemical oxidation of chlorhexidine and its amperometric determination by flow-injection analysischlorhexidine oxidationbare electrodeorganochlorideantisepticThe electrochemical oxidation of chlorhexidine is investigated for the first time and its amperometric determination using a flow-injection analysis (FIA) system is demonstrated. An oxidation peak was observed at around 1.3 V in a 0.1 mol L-1 HClO4 solution at a glassy-carbon electrode. The mechanism of the electrochemical oxidation of chlorhexidine is pH-dependent and involves a single-electron transfer possibly via radical cation formation. The FIA parameters were optimized and a detection limit of 0.3 µmol L-1 was obtained. The proposed method was applied in mouth rinses and skin disinfectants samples and compared with high-performance liquid chromatography.Sociedade Brasileira de Química2014-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532014000300006Journal of the Brazilian Chemical Society v.25 n.3 2014reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.5935/0103-5053.20130267info:eu-repo/semantics/openAccessLima,Ana Paula deStefano,Jessica S.Montes,Rodrigo H. O.Cunha,Rafael R.Silva,Luiz A. J.Richter,Eduardo M.Muñoz,Rodrigo A. A.eng2014-03-19T00:00:00Zoai:scielo:S0103-50532014000300006Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2014-03-19T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Electrochemical oxidation of chlorhexidine and its amperometric determination by flow-injection analysis
title Electrochemical oxidation of chlorhexidine and its amperometric determination by flow-injection analysis
spellingShingle Electrochemical oxidation of chlorhexidine and its amperometric determination by flow-injection analysis
Lima,Ana Paula de
chlorhexidine oxidation
bare electrode
organochloride
antiseptic
title_short Electrochemical oxidation of chlorhexidine and its amperometric determination by flow-injection analysis
title_full Electrochemical oxidation of chlorhexidine and its amperometric determination by flow-injection analysis
title_fullStr Electrochemical oxidation of chlorhexidine and its amperometric determination by flow-injection analysis
title_full_unstemmed Electrochemical oxidation of chlorhexidine and its amperometric determination by flow-injection analysis
title_sort Electrochemical oxidation of chlorhexidine and its amperometric determination by flow-injection analysis
author Lima,Ana Paula de
author_facet Lima,Ana Paula de
Stefano,Jessica S.
Montes,Rodrigo H. O.
Cunha,Rafael R.
Silva,Luiz A. J.
Richter,Eduardo M.
Muñoz,Rodrigo A. A.
author_role author
author2 Stefano,Jessica S.
Montes,Rodrigo H. O.
Cunha,Rafael R.
Silva,Luiz A. J.
Richter,Eduardo M.
Muñoz,Rodrigo A. A.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Lima,Ana Paula de
Stefano,Jessica S.
Montes,Rodrigo H. O.
Cunha,Rafael R.
Silva,Luiz A. J.
Richter,Eduardo M.
Muñoz,Rodrigo A. A.
dc.subject.por.fl_str_mv chlorhexidine oxidation
bare electrode
organochloride
antiseptic
topic chlorhexidine oxidation
bare electrode
organochloride
antiseptic
description The electrochemical oxidation of chlorhexidine is investigated for the first time and its amperometric determination using a flow-injection analysis (FIA) system is demonstrated. An oxidation peak was observed at around 1.3 V in a 0.1 mol L-1 HClO4 solution at a glassy-carbon electrode. The mechanism of the electrochemical oxidation of chlorhexidine is pH-dependent and involves a single-electron transfer possibly via radical cation formation. The FIA parameters were optimized and a detection limit of 0.3 µmol L-1 was obtained. The proposed method was applied in mouth rinses and skin disinfectants samples and compared with high-performance liquid chromatography.
publishDate 2014
dc.date.none.fl_str_mv 2014-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532014000300006
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532014000300006
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/0103-5053.20130267
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.25 n.3 2014
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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