Synthesis and antiproliferative activity of novel limonene derivatives with a substituted thiourea moiety

Detalhes bibliográficos
Autor(a) principal: Figueiredo,Isis M.
Data de Publicação: 2006
Outros Autores: Santos,Luciane V. dos, Costa,Willian F. da, Carvalho,João E. de, Silva,Cleuza C. da, Sacoman,Juliana L., Kohn,Luciana K., Sarragiotto,Maria H.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532006000500020
Resumo: A series of R-(+)-limonene derivatives bearing a substituted thiourea moiety (3-13) and five S-methyl analogs (14-18) were synthesized and evaluated for their in vitro antiproliferative activity against human cancer cell lines. Compounds bearing aromatic substituents (3-6) exhibit cytotastic activity in the full panel of cell lines tested, with GI50 values in the range of 2.5 to 24 µmol L-1. Compounds 3, 10, 12 and 16 were the most active with GI50 values in the range of 0.41 to 3.0 µmol L-1, against different cell lines.
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spelling Synthesis and antiproliferative activity of novel limonene derivatives with a substituted thiourea moietylimonene derivativesthioureasantiproliferative activityA series of R-(+)-limonene derivatives bearing a substituted thiourea moiety (3-13) and five S-methyl analogs (14-18) were synthesized and evaluated for their in vitro antiproliferative activity against human cancer cell lines. Compounds bearing aromatic substituents (3-6) exhibit cytotastic activity in the full panel of cell lines tested, with GI50 values in the range of 2.5 to 24 µmol L-1. Compounds 3, 10, 12 and 16 were the most active with GI50 values in the range of 0.41 to 3.0 µmol L-1, against different cell lines.Sociedade Brasileira de Química2006-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532006000500020Journal of the Brazilian Chemical Society v.17 n.5 2006reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532006000500020info:eu-repo/semantics/openAccessFigueiredo,Isis M.Santos,Luciane V. dosCosta,Willian F. daCarvalho,João E. deSilva,Cleuza C. daSacoman,Juliana L.Kohn,Luciana K.Sarragiotto,Maria H.eng2006-12-01T00:00:00Zoai:scielo:S0103-50532006000500020Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2006-12-01T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Synthesis and antiproliferative activity of novel limonene derivatives with a substituted thiourea moiety
title Synthesis and antiproliferative activity of novel limonene derivatives with a substituted thiourea moiety
spellingShingle Synthesis and antiproliferative activity of novel limonene derivatives with a substituted thiourea moiety
Figueiredo,Isis M.
limonene derivatives
thioureas
antiproliferative activity
title_short Synthesis and antiproliferative activity of novel limonene derivatives with a substituted thiourea moiety
title_full Synthesis and antiproliferative activity of novel limonene derivatives with a substituted thiourea moiety
title_fullStr Synthesis and antiproliferative activity of novel limonene derivatives with a substituted thiourea moiety
title_full_unstemmed Synthesis and antiproliferative activity of novel limonene derivatives with a substituted thiourea moiety
title_sort Synthesis and antiproliferative activity of novel limonene derivatives with a substituted thiourea moiety
author Figueiredo,Isis M.
author_facet Figueiredo,Isis M.
Santos,Luciane V. dos
Costa,Willian F. da
Carvalho,João E. de
Silva,Cleuza C. da
Sacoman,Juliana L.
Kohn,Luciana K.
Sarragiotto,Maria H.
author_role author
author2 Santos,Luciane V. dos
Costa,Willian F. da
Carvalho,João E. de
Silva,Cleuza C. da
Sacoman,Juliana L.
Kohn,Luciana K.
Sarragiotto,Maria H.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Figueiredo,Isis M.
Santos,Luciane V. dos
Costa,Willian F. da
Carvalho,João E. de
Silva,Cleuza C. da
Sacoman,Juliana L.
Kohn,Luciana K.
Sarragiotto,Maria H.
dc.subject.por.fl_str_mv limonene derivatives
thioureas
antiproliferative activity
topic limonene derivatives
thioureas
antiproliferative activity
description A series of R-(+)-limonene derivatives bearing a substituted thiourea moiety (3-13) and five S-methyl analogs (14-18) were synthesized and evaluated for their in vitro antiproliferative activity against human cancer cell lines. Compounds bearing aromatic substituents (3-6) exhibit cytotastic activity in the full panel of cell lines tested, with GI50 values in the range of 2.5 to 24 µmol L-1. Compounds 3, 10, 12 and 16 were the most active with GI50 values in the range of 0.41 to 3.0 µmol L-1, against different cell lines.
publishDate 2006
dc.date.none.fl_str_mv 2006-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532006000500020
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532006000500020
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-50532006000500020
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.17 n.5 2006
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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