Synthesis and in vitro activity of limonene derivatives against Leishmania and Trypanosoma

Detalhes bibliográficos
Autor(a) principal: Graebin, Cedric S.
Data de Publicação: 2010
Outros Autores: Madeira, Maria de F., Yokoyama-Yasunaka, Jenicer K. U., Miguel, Danilo C., Uliana, Silvia Reni Bortolin, Benitez, Diego, Cerecetto, Hugo, González, Mercedes, Rosa, Ricardo Gomes da, Eifler-Lima, Vera Lucia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/37461
Resumo: 2020-11-28
id CRUZ_ce79a28050a779ffb0e84f49bb34faeb
oai_identifier_str oai:www.arca.fiocruz.br:icict/37461
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Graebin, Cedric S.Madeira, Maria de F.Yokoyama-Yasunaka, Jenicer K. U.Miguel, Danilo C.Uliana, Silvia Reni BortolinBenitez, DiegoCerecetto, HugoGonzález, MercedesRosa, Ricardo Gomes daEifler-Lima, Vera Lucia2019-11-28T14:59:30Z2019-11-28T14:59:30Z2010GRAEBIN, Cedric S. et al. Synthesis and in vitro activity of limonene derivatives against Leishmania and Trypanosoma. European Journal of Medicinal Chemistry, v. 45, p. 1524-1528, 2010.0223-5234https://www.arca.fiocruz.br/handle/icict/3746110.1016/j.ejmech.2009.12.0611768-3254engElsevierSynthesis and in vitro activity of limonene derivatives against Leishmania and Trypanosomainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-11-28Universidade Federal do Rio Grande do Sul. Faculdade de Farmácia. Laboratório de Síntese Orgânica Medicinal. Porto Alegre, RS, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas Serviço de Parasitologia. Rio de Janeiro, RJ, Brasil.Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, Brasil.Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, Brasil.Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, Brasil.Universidad de la República. Facultad de Ciencias/Química. Departamento de Química Orgânica. Montevideo, Uruguay.Universidad de la República. Facultad de Ciencias/Química. Departamento de Química Orgânica. Montevideo, Uruguay.Universidad de la República. Facultad de Ciencias/Química. Departamento de Química Orgânica. Montevideo, Uruguay.Universidade Federal do Rio Grande do Sul. Instituto de Química. Laboratório de Catálise por Metais de Transição. Porto Alegre, RS, Brasil.Universidade Federal do Rio Grande do Sul. Faculdade de Farmácia. Laboratório de Síntese Orgânica Medicinal. Porto Alegre, RS, Brasil.The synthesis and in vitro activity of R(þ)-Limonene derivatives against Leishmania and Trypanosoma cruzi strains are reported. Seven compounds have shown better in vitro activity against Leishmania (V.)braziliensis than the standard drug pentamidine. Additionally, we have identified two promising new anti-T. cruzi limonene derivatives.LimoneneLeishmaniaTrypanosoma cruziAnti-parasitic activityHydroaminomethylationinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/37461/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Graebin_Cedric_etal_INI_2010.pdfve_Graebin_Cedric_etal_INI_2010.pdfapplication/pdf287343https://www.arca.fiocruz.br/bitstream/icict/37461/2/ve_Graebin_Cedric_etal_INI_2010.pdfe668ae5a088a52a8b62f3147e209f6a9MD52TEXTve_Graebin_Cedric_etal_INI_2010.pdf.txtve_Graebin_Cedric_etal_INI_2010.pdf.txtExtracted texttext/plain25940https://www.arca.fiocruz.br/bitstream/icict/37461/3/ve_Graebin_Cedric_etal_INI_2010.pdf.txt8d2cd71180c7657334420177eab7f887MD53icict/374612021-09-06 10:49:22.716oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-09-06T13:49:22Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Synthesis and in vitro activity of limonene derivatives against Leishmania and Trypanosoma
title Synthesis and in vitro activity of limonene derivatives against Leishmania and Trypanosoma
spellingShingle Synthesis and in vitro activity of limonene derivatives against Leishmania and Trypanosoma
Graebin, Cedric S.
Limonene
Leishmania
Trypanosoma cruzi
Anti-parasitic activity
Hydroaminomethylation
title_short Synthesis and in vitro activity of limonene derivatives against Leishmania and Trypanosoma
title_full Synthesis and in vitro activity of limonene derivatives against Leishmania and Trypanosoma
title_fullStr Synthesis and in vitro activity of limonene derivatives against Leishmania and Trypanosoma
title_full_unstemmed Synthesis and in vitro activity of limonene derivatives against Leishmania and Trypanosoma
title_sort Synthesis and in vitro activity of limonene derivatives against Leishmania and Trypanosoma
author Graebin, Cedric S.
author_facet Graebin, Cedric S.
Madeira, Maria de F.
Yokoyama-Yasunaka, Jenicer K. U.
Miguel, Danilo C.
Uliana, Silvia Reni Bortolin
Benitez, Diego
Cerecetto, Hugo
González, Mercedes
Rosa, Ricardo Gomes da
Eifler-Lima, Vera Lucia
author_role author
author2 Madeira, Maria de F.
Yokoyama-Yasunaka, Jenicer K. U.
Miguel, Danilo C.
Uliana, Silvia Reni Bortolin
Benitez, Diego
Cerecetto, Hugo
González, Mercedes
Rosa, Ricardo Gomes da
Eifler-Lima, Vera Lucia
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Graebin, Cedric S.
Madeira, Maria de F.
Yokoyama-Yasunaka, Jenicer K. U.
Miguel, Danilo C.
Uliana, Silvia Reni Bortolin
Benitez, Diego
Cerecetto, Hugo
González, Mercedes
Rosa, Ricardo Gomes da
Eifler-Lima, Vera Lucia
dc.subject.en.pt_BR.fl_str_mv Limonene
Leishmania
Trypanosoma cruzi
Anti-parasitic activity
Hydroaminomethylation
topic Limonene
Leishmania
Trypanosoma cruzi
Anti-parasitic activity
Hydroaminomethylation
description 2020-11-28
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2019-11-28T14:59:30Z
dc.date.available.fl_str_mv 2019-11-28T14:59:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GRAEBIN, Cedric S. et al. Synthesis and in vitro activity of limonene derivatives against Leishmania and Trypanosoma. European Journal of Medicinal Chemistry, v. 45, p. 1524-1528, 2010.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/37461
dc.identifier.issn.pt_BR.fl_str_mv 0223-5234
dc.identifier.doi.none.fl_str_mv 10.1016/j.ejmech.2009.12.061
dc.identifier.eissn.none.fl_str_mv 1768-3254
identifier_str_mv GRAEBIN, Cedric S. et al. Synthesis and in vitro activity of limonene derivatives against Leishmania and Trypanosoma. European Journal of Medicinal Chemistry, v. 45, p. 1524-1528, 2010.
0223-5234
10.1016/j.ejmech.2009.12.061
1768-3254
url https://www.arca.fiocruz.br/handle/icict/37461
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/37461/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/37461/2/ve_Graebin_Cedric_etal_INI_2010.pdf
https://www.arca.fiocruz.br/bitstream/icict/37461/3/ve_Graebin_Cedric_etal_INI_2010.pdf.txt
bitstream.checksum.fl_str_mv 8a4605be74aa9ea9d79846c1fba20a33
e668ae5a088a52a8b62f3147e209f6a9
8d2cd71180c7657334420177eab7f887
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1813009209774571520

Registros relacionados