Synthesis of platinum complexes from N-benzyl ethylenediamine derivatives

Detalhes bibliográficos
Autor(a) principal: Almeida,Mauro V. de
Data de Publicação: 2000
Outros Autores: Cesar,Eloi T., Felício,Emanoel de C. A., Fontes,Ana Paula S., Robert-Gero,Malka
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532000000200009
Resumo: N-benzylethylenediamine derivatives have been prepared in good yields using methodology diferent than that described in the literature. ¹H and 13C NMR spectra were used to characterize those compounds. Nine new platinum(II) complexes, analogs of cisplatin and carboplatin, containing these ligands have been prepared and characterized. Preliminary in vitro tests against buccal human carcinoma cell lines (KB cells) showed that the complexes are cytotoxic.
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spelling Synthesis of platinum complexes from N-benzyl ethylenediamine derivativesplatinum(II) complexesN-benzylethylenediamineanticancer agentssubstitution reactionsN-benzylethylenediamine derivatives have been prepared in good yields using methodology diferent than that described in the literature. ¹H and 13C NMR spectra were used to characterize those compounds. Nine new platinum(II) complexes, analogs of cisplatin and carboplatin, containing these ligands have been prepared and characterized. Preliminary in vitro tests against buccal human carcinoma cell lines (KB cells) showed that the complexes are cytotoxic.Sociedade Brasileira de Química2000-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532000000200009Journal of the Brazilian Chemical Society v.11 n.2 2000reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532000000200009info:eu-repo/semantics/openAccessAlmeida,Mauro V. deCesar,Eloi T.Felício,Emanoel de C. A.Fontes,Ana Paula S.Robert-Gero,Malkaeng2000-10-23T00:00:00Zoai:scielo:S0103-50532000000200009Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2000-10-23T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Synthesis of platinum complexes from N-benzyl ethylenediamine derivatives
title Synthesis of platinum complexes from N-benzyl ethylenediamine derivatives
spellingShingle Synthesis of platinum complexes from N-benzyl ethylenediamine derivatives
Almeida,Mauro V. de
platinum(II) complexes
N-benzylethylenediamine
anticancer agents
substitution reactions
title_short Synthesis of platinum complexes from N-benzyl ethylenediamine derivatives
title_full Synthesis of platinum complexes from N-benzyl ethylenediamine derivatives
title_fullStr Synthesis of platinum complexes from N-benzyl ethylenediamine derivatives
title_full_unstemmed Synthesis of platinum complexes from N-benzyl ethylenediamine derivatives
title_sort Synthesis of platinum complexes from N-benzyl ethylenediamine derivatives
author Almeida,Mauro V. de
author_facet Almeida,Mauro V. de
Cesar,Eloi T.
Felício,Emanoel de C. A.
Fontes,Ana Paula S.
Robert-Gero,Malka
author_role author
author2 Cesar,Eloi T.
Felício,Emanoel de C. A.
Fontes,Ana Paula S.
Robert-Gero,Malka
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Almeida,Mauro V. de
Cesar,Eloi T.
Felício,Emanoel de C. A.
Fontes,Ana Paula S.
Robert-Gero,Malka
dc.subject.por.fl_str_mv platinum(II) complexes
N-benzylethylenediamine
anticancer agents
substitution reactions
topic platinum(II) complexes
N-benzylethylenediamine
anticancer agents
substitution reactions
description N-benzylethylenediamine derivatives have been prepared in good yields using methodology diferent than that described in the literature. ¹H and 13C NMR spectra were used to characterize those compounds. Nine new platinum(II) complexes, analogs of cisplatin and carboplatin, containing these ligands have been prepared and characterized. Preliminary in vitro tests against buccal human carcinoma cell lines (KB cells) showed that the complexes are cytotoxic.
publishDate 2000
dc.date.none.fl_str_mv 2000-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532000000200009
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532000000200009
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-50532000000200009
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.11 n.2 2000
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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