Synthesis of platinum complexes from N-benzyl ethylenediamine derivatives

Detalhes bibliográficos
Autor(a) principal: Almeida, Mauro Vieira de
Data de Publicação: 2000
Outros Autores: César, Elói Teixeira, Felício, Emanoel de Castro Antunes, Fontes, Ana Paula Soares, Robert-Gero, Malka
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFJF
Texto Completo: http://dx.doi.org/10.1590/S0103-50532000000200009
https://repositorio.ufjf.br/jspui/handle/ufjf/9185
Resumo: O ligante N-benziletilenodiamina e derivados foram preparados em bons rendimentos utilizando-se metodologia diferente da descrita na literatura. Espectros de RMN de 1H e de 13C foram empregados para a caracterização destes compostos. Nove novos complexos de platina(II) com estes ligantes, análogos da cisplatina e da carboplatina, foram preparados e caracterizados. Testes preliminares in vitro em linhagens celulares de carcinoma bucal humano (células KB) indicam que estes complexos são citotóxicos.
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spelling 2019-02-22T13:35:00Z2019-02-212019-02-22T13:35:00Z2000-04112154158http://dx.doi.org/10.1590/S0103-50532000000200009https://repositorio.ufjf.br/jspui/handle/ufjf/9185O ligante N-benziletilenodiamina e derivados foram preparados em bons rendimentos utilizando-se metodologia diferente da descrita na literatura. Espectros de RMN de 1H e de 13C foram empregados para a caracterização destes compostos. Nove novos complexos de platina(II) com estes ligantes, análogos da cisplatina e da carboplatina, foram preparados e caracterizados. Testes preliminares in vitro em linhagens celulares de carcinoma bucal humano (células KB) indicam que estes complexos são citotóxicos.N-benzylethylenediamine derivatives have been prepared in good yields using methodology diferent than that described in the literature. 1H and 13C NMR spectra were used to characterize those compounds. Nine new platinum(II) complexes, analogs of cisplatin and carboplatin, containing these ligands have been prepared and characterized. Preliminary in vitro tests against buccal human carcinoma cell lines (KB cells) showed that the complexes are cytotoxic.eng--BrasilJournal of the Brazilian Chemical Society-Platinum(II) complexesN-benzylethylenediamineAnticancer agentsSubstitution reactionsSynthesis of platinum complexes from N-benzyl ethylenediamine derivativesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleAlmeida, Mauro Vieira deCésar, Elói TeixeiraFelício, Emanoel de Castro AntunesFontes, Ana Paula SoaresRobert-Gero, Malkainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFJFinstname:Universidade Federal de Juiz de Fora (UFJF)instacron:UFJFTHUMBNAILSynthesis of platinum complexes from N-benzyl ethylenediamine derivatives.pdf.jpgSynthesis of platinum complexes from N-benzyl ethylenediamine derivatives.pdf.jpgGenerated Thumbnailimage/jpeg1546https://repositorio.ufjf.br/jspui/bitstream/ufjf/9185/6/Synthesis%20of%20platinum%20complexes%20from%20N-benzyl%20ethylenediamine%20derivatives.pdf.jpgfd8da71465571743936c092eeb0898c7MD56ORIGINALSynthesis of platinum complexes from N-benzyl ethylenediamine derivatives.pdfSynthesis of platinum complexes from N-benzyl ethylenediamine derivatives.pdfapplication/pdf39696https://repositorio.ufjf.br/jspui/bitstream/ufjf/9185/3/Synthesis%20of%20platinum%20complexes%20from%20N-benzyl%20ethylenediamine%20derivatives.pdfe87e811697d4fc4bec5489549343e546MD53LICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv Synthesis of platinum complexes from N-benzyl ethylenediamine derivatives
title Synthesis of platinum complexes from N-benzyl ethylenediamine derivatives
spellingShingle Synthesis of platinum complexes from N-benzyl ethylenediamine derivatives
Almeida, Mauro Vieira de
-
Platinum(II) complexes
N-benzylethylenediamine
Anticancer agents
Substitution reactions
title_short Synthesis of platinum complexes from N-benzyl ethylenediamine derivatives
title_full Synthesis of platinum complexes from N-benzyl ethylenediamine derivatives
title_fullStr Synthesis of platinum complexes from N-benzyl ethylenediamine derivatives
title_full_unstemmed Synthesis of platinum complexes from N-benzyl ethylenediamine derivatives
title_sort Synthesis of platinum complexes from N-benzyl ethylenediamine derivatives
author Almeida, Mauro Vieira de
author_facet Almeida, Mauro Vieira de
César, Elói Teixeira
Felício, Emanoel de Castro Antunes
Fontes, Ana Paula Soares
Robert-Gero, Malka
author_role author
author2 César, Elói Teixeira
Felício, Emanoel de Castro Antunes
Fontes, Ana Paula Soares
Robert-Gero, Malka
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Almeida, Mauro Vieira de
César, Elói Teixeira
Felício, Emanoel de Castro Antunes
Fontes, Ana Paula Soares
Robert-Gero, Malka
dc.subject.cnpq.fl_str_mv -
topic -
Platinum(II) complexes
N-benzylethylenediamine
Anticancer agents
Substitution reactions
dc.subject.por.fl_str_mv Platinum(II) complexes
N-benzylethylenediamine
Anticancer agents
Substitution reactions
description O ligante N-benziletilenodiamina e derivados foram preparados em bons rendimentos utilizando-se metodologia diferente da descrita na literatura. Espectros de RMN de 1H e de 13C foram empregados para a caracterização destes compostos. Nove novos complexos de platina(II) com estes ligantes, análogos da cisplatina e da carboplatina, foram preparados e caracterizados. Testes preliminares in vitro em linhagens celulares de carcinoma bucal humano (células KB) indicam que estes complexos são citotóxicos.
publishDate 2000
dc.date.issued.fl_str_mv 2000-04
dc.date.accessioned.fl_str_mv 2019-02-22T13:35:00Z
dc.date.available.fl_str_mv 2019-02-21
2019-02-22T13:35:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://repositorio.ufjf.br/jspui/handle/ufjf/9185
dc.identifier.doi.pt_BR.fl_str_mv http://dx.doi.org/10.1590/S0103-50532000000200009
url http://dx.doi.org/10.1590/S0103-50532000000200009
https://repositorio.ufjf.br/jspui/handle/ufjf/9185
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.pt_BR.fl_str_mv Journal of the Brazilian Chemical Society
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv -
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dc.publisher.country.fl_str_mv Brasil
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dc.source.none.fl_str_mv reponame:Repositório Institucional da UFJF
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