Implementation of a Spectrofluorimetric Method to the Determination of 8-Methoxypsoralen in Capsules and Creams Used in Treatment of Psoriasis and Vitiligo: an Evaluation of the Quality of Compounding Pharmacies in Rio de Janeiro

Detalhes bibliográficos
Autor(a) principal: Oliveira,Catarina A.
Data de Publicação: 2017
Outros Autores: Gouvêa,Marcos M., Ribeiro,Flávio H. S. A., Ricci-Júnior,Eduardo, Marques,Flávia F. C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532017000801517
Resumo: 8-Methoxypsoralen is a widely sold drug in Brazil as handled capsules and creams because it is only industrially available as soft gel capsules of 10 mg. In order to contribute to the quality control of these pharmaceutical forms, a spectrofluorimetric method was implemented and applied for the evaluation of the quality of compounding pharmacies in the state of Rio de Janeiro (Brazil). Solutions of 8-methoxypsoralen prepared in ethanol/water (30:70 v/v) produced fluorescence signals at excitation/emission wavelengths of 305/495 nm. The method presented good precision (relative standard deviation, RSD < 4.8%) and recoveries in the pharmaceutical samples from 88.5-108% indicated its feasibility. The results of assay (dosing) and uniformity of content suggested that two of the three evaluated pharmacies did not have appropriate techniques in the preparation of these formulations, which could potentially reduce the efficiency of dermatoses treatment. The implemented method is an alternative to those described in literature for pharmaceutical forms containing 8-methoxypsoralen.
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spelling Implementation of a Spectrofluorimetric Method to the Determination of 8-Methoxypsoralen in Capsules and Creams Used in Treatment of Psoriasis and Vitiligo: an Evaluation of the Quality of Compounding Pharmacies in Rio de Janeiro8-methoxypsoralenspectrofluorimetrycompounded medicinequality controlcompounding pharmacydermatosis8-Methoxypsoralen is a widely sold drug in Brazil as handled capsules and creams because it is only industrially available as soft gel capsules of 10 mg. In order to contribute to the quality control of these pharmaceutical forms, a spectrofluorimetric method was implemented and applied for the evaluation of the quality of compounding pharmacies in the state of Rio de Janeiro (Brazil). Solutions of 8-methoxypsoralen prepared in ethanol/water (30:70 v/v) produced fluorescence signals at excitation/emission wavelengths of 305/495 nm. The method presented good precision (relative standard deviation, RSD < 4.8%) and recoveries in the pharmaceutical samples from 88.5-108% indicated its feasibility. The results of assay (dosing) and uniformity of content suggested that two of the three evaluated pharmacies did not have appropriate techniques in the preparation of these formulations, which could potentially reduce the efficiency of dermatoses treatment. The implemented method is an alternative to those described in literature for pharmaceutical forms containing 8-methoxypsoralen.Sociedade Brasileira de Química2017-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532017000801517Journal of the Brazilian Chemical Society v.28 n.8 2017reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.21577/0103-5053.20170003info:eu-repo/semantics/openAccessOliveira,Catarina A.Gouvêa,Marcos M.Ribeiro,Flávio H. S. A.Ricci-Júnior,EduardoMarques,Flávia F. C.eng2017-07-18T00:00:00Zoai:scielo:S0103-50532017000801517Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2017-07-18T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Implementation of a Spectrofluorimetric Method to the Determination of 8-Methoxypsoralen in Capsules and Creams Used in Treatment of Psoriasis and Vitiligo: an Evaluation of the Quality of Compounding Pharmacies in Rio de Janeiro
title Implementation of a Spectrofluorimetric Method to the Determination of 8-Methoxypsoralen in Capsules and Creams Used in Treatment of Psoriasis and Vitiligo: an Evaluation of the Quality of Compounding Pharmacies in Rio de Janeiro
spellingShingle Implementation of a Spectrofluorimetric Method to the Determination of 8-Methoxypsoralen in Capsules and Creams Used in Treatment of Psoriasis and Vitiligo: an Evaluation of the Quality of Compounding Pharmacies in Rio de Janeiro
Oliveira,Catarina A.
8-methoxypsoralen
spectrofluorimetry
compounded medicine
quality control
compounding pharmacy
dermatosis
title_short Implementation of a Spectrofluorimetric Method to the Determination of 8-Methoxypsoralen in Capsules and Creams Used in Treatment of Psoriasis and Vitiligo: an Evaluation of the Quality of Compounding Pharmacies in Rio de Janeiro
title_full Implementation of a Spectrofluorimetric Method to the Determination of 8-Methoxypsoralen in Capsules and Creams Used in Treatment of Psoriasis and Vitiligo: an Evaluation of the Quality of Compounding Pharmacies in Rio de Janeiro
title_fullStr Implementation of a Spectrofluorimetric Method to the Determination of 8-Methoxypsoralen in Capsules and Creams Used in Treatment of Psoriasis and Vitiligo: an Evaluation of the Quality of Compounding Pharmacies in Rio de Janeiro
title_full_unstemmed Implementation of a Spectrofluorimetric Method to the Determination of 8-Methoxypsoralen in Capsules and Creams Used in Treatment of Psoriasis and Vitiligo: an Evaluation of the Quality of Compounding Pharmacies in Rio de Janeiro
title_sort Implementation of a Spectrofluorimetric Method to the Determination of 8-Methoxypsoralen in Capsules and Creams Used in Treatment of Psoriasis and Vitiligo: an Evaluation of the Quality of Compounding Pharmacies in Rio de Janeiro
author Oliveira,Catarina A.
author_facet Oliveira,Catarina A.
Gouvêa,Marcos M.
Ribeiro,Flávio H. S. A.
Ricci-Júnior,Eduardo
Marques,Flávia F. C.
author_role author
author2 Gouvêa,Marcos M.
Ribeiro,Flávio H. S. A.
Ricci-Júnior,Eduardo
Marques,Flávia F. C.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Oliveira,Catarina A.
Gouvêa,Marcos M.
Ribeiro,Flávio H. S. A.
Ricci-Júnior,Eduardo
Marques,Flávia F. C.
dc.subject.por.fl_str_mv 8-methoxypsoralen
spectrofluorimetry
compounded medicine
quality control
compounding pharmacy
dermatosis
topic 8-methoxypsoralen
spectrofluorimetry
compounded medicine
quality control
compounding pharmacy
dermatosis
description 8-Methoxypsoralen is a widely sold drug in Brazil as handled capsules and creams because it is only industrially available as soft gel capsules of 10 mg. In order to contribute to the quality control of these pharmaceutical forms, a spectrofluorimetric method was implemented and applied for the evaluation of the quality of compounding pharmacies in the state of Rio de Janeiro (Brazil). Solutions of 8-methoxypsoralen prepared in ethanol/water (30:70 v/v) produced fluorescence signals at excitation/emission wavelengths of 305/495 nm. The method presented good precision (relative standard deviation, RSD < 4.8%) and recoveries in the pharmaceutical samples from 88.5-108% indicated its feasibility. The results of assay (dosing) and uniformity of content suggested that two of the three evaluated pharmacies did not have appropriate techniques in the preparation of these formulations, which could potentially reduce the efficiency of dermatoses treatment. The implemented method is an alternative to those described in literature for pharmaceutical forms containing 8-methoxypsoralen.
publishDate 2017
dc.date.none.fl_str_mv 2017-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532017000801517
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532017000801517
dc.language.iso.fl_str_mv eng
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dc.relation.none.fl_str_mv 10.21577/0103-5053.20170003
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dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.28 n.8 2017
reponame:Journal of the Brazilian Chemical Society (Online)
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reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
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