Antitumoral, antileishmanial and antimalarial activity of pentacyclic 1,4-naphthoquinone derivatives

Detalhes bibliográficos
Autor(a) principal: Silva,Alcides J.M. da
Data de Publicação: 2009
Outros Autores: Netto,Chaquip D., Pacienza-Lima,Wallace, Torres-Santos,Eduardo Caio, Rossi-Bergmann,Bartira, Maurel,Severine, Valentin,Alexis, Costa,Paulo R.R.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532009000100026
Resumo: Pterocarpanquinones 8a-c, previously synthesized in our laboratory, and an homologous series of derivatives, compounds 9a-c prepared in this work, were evaluated on breast cancer cells (MCF-7) and on the parasites Leishmania amazonensis and Plasmodium falciparum, in culture. Compounds 8a-c were more potent than 9a-c on tumor cells and Leishmania amazonensis. On the other hand, 9a-c showed to be more active on Plasmodium falciparum. All the compounds studied were bioselective, presenting negligible cytotoxicity against fresh murine lymphocytes and human lymphocytes activated by the mitogen phytohemaglutinin (PHA).
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spelling Antitumoral, antileishmanial and antimalarial activity of pentacyclic 1,4-naphthoquinone derivativesantineoplasicantiparasiticpterocarpansnaphtoquinonesoxa-Heck reactionantimalarialleishmanicidePterocarpanquinones 8a-c, previously synthesized in our laboratory, and an homologous series of derivatives, compounds 9a-c prepared in this work, were evaluated on breast cancer cells (MCF-7) and on the parasites Leishmania amazonensis and Plasmodium falciparum, in culture. Compounds 8a-c were more potent than 9a-c on tumor cells and Leishmania amazonensis. On the other hand, 9a-c showed to be more active on Plasmodium falciparum. All the compounds studied were bioselective, presenting negligible cytotoxicity against fresh murine lymphocytes and human lymphocytes activated by the mitogen phytohemaglutinin (PHA).Sociedade Brasileira de Química2009-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532009000100026Journal of the Brazilian Chemical Society v.20 n.1 2009reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532009000100026info:eu-repo/semantics/openAccessSilva,Alcides J.M. daNetto,Chaquip D.Pacienza-Lima,WallaceTorres-Santos,Eduardo CaioRossi-Bergmann,BartiraMaurel,SeverineValentin,AlexisCosta,Paulo R.R.eng2009-01-21T00:00:00Zoai:scielo:S0103-50532009000100026Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2009-01-21T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Antitumoral, antileishmanial and antimalarial activity of pentacyclic 1,4-naphthoquinone derivatives
title Antitumoral, antileishmanial and antimalarial activity of pentacyclic 1,4-naphthoquinone derivatives
spellingShingle Antitumoral, antileishmanial and antimalarial activity of pentacyclic 1,4-naphthoquinone derivatives
Silva,Alcides J.M. da
antineoplasic
antiparasitic
pterocarpans
naphtoquinones
oxa-Heck reaction
antimalarial
leishmanicide
title_short Antitumoral, antileishmanial and antimalarial activity of pentacyclic 1,4-naphthoquinone derivatives
title_full Antitumoral, antileishmanial and antimalarial activity of pentacyclic 1,4-naphthoquinone derivatives
title_fullStr Antitumoral, antileishmanial and antimalarial activity of pentacyclic 1,4-naphthoquinone derivatives
title_full_unstemmed Antitumoral, antileishmanial and antimalarial activity of pentacyclic 1,4-naphthoquinone derivatives
title_sort Antitumoral, antileishmanial and antimalarial activity of pentacyclic 1,4-naphthoquinone derivatives
author Silva,Alcides J.M. da
author_facet Silva,Alcides J.M. da
Netto,Chaquip D.
Pacienza-Lima,Wallace
Torres-Santos,Eduardo Caio
Rossi-Bergmann,Bartira
Maurel,Severine
Valentin,Alexis
Costa,Paulo R.R.
author_role author
author2 Netto,Chaquip D.
Pacienza-Lima,Wallace
Torres-Santos,Eduardo Caio
Rossi-Bergmann,Bartira
Maurel,Severine
Valentin,Alexis
Costa,Paulo R.R.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Silva,Alcides J.M. da
Netto,Chaquip D.
Pacienza-Lima,Wallace
Torres-Santos,Eduardo Caio
Rossi-Bergmann,Bartira
Maurel,Severine
Valentin,Alexis
Costa,Paulo R.R.
dc.subject.por.fl_str_mv antineoplasic
antiparasitic
pterocarpans
naphtoquinones
oxa-Heck reaction
antimalarial
leishmanicide
topic antineoplasic
antiparasitic
pterocarpans
naphtoquinones
oxa-Heck reaction
antimalarial
leishmanicide
description Pterocarpanquinones 8a-c, previously synthesized in our laboratory, and an homologous series of derivatives, compounds 9a-c prepared in this work, were evaluated on breast cancer cells (MCF-7) and on the parasites Leishmania amazonensis and Plasmodium falciparum, in culture. Compounds 8a-c were more potent than 9a-c on tumor cells and Leishmania amazonensis. On the other hand, 9a-c showed to be more active on Plasmodium falciparum. All the compounds studied were bioselective, presenting negligible cytotoxicity against fresh murine lymphocytes and human lymphocytes activated by the mitogen phytohemaglutinin (PHA).
publishDate 2009
dc.date.none.fl_str_mv 2009-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532009000100026
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532009000100026
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-50532009000100026
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.20 n.1 2009
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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