Chemoenzymatic Synthesis and Anti-Inflammatory Activity of Fatty Acid Amides Prepared from Bertholletia excelsa (Brazil Nut) Triglycerides

• Autor(a) principal: Barata,Pedro H. S.
• Data de Publicação: 2020
• Outros Autores: Sarquis,Ícaro R., Carvalho,Helison O., Barros,Albenise S., Rodrigues,Alex B., Galue-Parra,Adan J., Silva,Edilene O., Carvalho,José Carlos T., Ferreira,Irlon M.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Journal of the Brazilian Chemical Society (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532020000801557
• topic: direct aminolysis; biocatalysis; oleoylethanolamine; palmitoethanolamide; alkylamides

This study reports the synthesis of fatty acid amides (FAA), analogous to anandamide, prepared from Brazil nut oil (BNO), using Amano lipase from Pseudomonas fluorescens as a catalyst of direct aminolysis, with a good yield (95-68%). The anti-inflammatory effects of BNO and FAA were evaluated by the carrageenan-induced paw edema method. Analysis of the formation of edema showed that these FAA, at all dose used, significantly reduced the development of edema.