Constituents from Maytenus ilicifolia leaves and bioguided fractionation for gastroprotective activity

Detalhes bibliográficos
Autor(a) principal: Leite,João Paulo V.
Data de Publicação: 2010
Outros Autores: Braga,Fernão C., Romussi,Giovanni, Persoli,Rita M., Tabach,Ricardo, Carlini,Elisaldo A., Oliveira,Alaíde B.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532010000200009
Resumo: Maytenus ilicifolia Mart. ex Reissek is traditionally used in Brazil for treatment of gastric ulcers. Here we report the phytochemical investigation of an ethanol extract of M. ilicifolia leaves (EEMIL) aiming at the isolation of constituents which were used as chemical markers to monitor an activity-guided fractionation of a lyophilized aqueous extract of M. ilicifolia leaves (LAEMIL). From EEMIL, four flavonoids were isolated, namely the tri-flavonoid glycosides mauritianin (1), trifolin, (2) hyperin (4), and epi-catechin (5). Fractionation of LAEMIL led to 5 fractions which afforded the tetra-glycoside kaempferol derivative (3), and galactitol (6). LAEMIL and its fractions were evaluated in rats for their effects on gastric secretion volume and pH. HPLC (High Performance Liquid Chromatography) analysis revealed that only fractions containing the tri- and tetra-flavonoid glycosides 1 and 3 caused significant increase of gastric volume and pH, thus indicating that these glycosides play an important role on the gastroprotective effect of M.ilicifolia leaves.
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spelling Constituents from Maytenus ilicifolia leaves and bioguided fractionation for gastroprotective activityMaytenus ilicifoliaflavonoid glycosidesgastroprotective activityliquid chromatographyMaytenus ilicifolia Mart. ex Reissek is traditionally used in Brazil for treatment of gastric ulcers. Here we report the phytochemical investigation of an ethanol extract of M. ilicifolia leaves (EEMIL) aiming at the isolation of constituents which were used as chemical markers to monitor an activity-guided fractionation of a lyophilized aqueous extract of M. ilicifolia leaves (LAEMIL). From EEMIL, four flavonoids were isolated, namely the tri-flavonoid glycosides mauritianin (1), trifolin, (2) hyperin (4), and epi-catechin (5). Fractionation of LAEMIL led to 5 fractions which afforded the tetra-glycoside kaempferol derivative (3), and galactitol (6). LAEMIL and its fractions were evaluated in rats for their effects on gastric secretion volume and pH. HPLC (High Performance Liquid Chromatography) analysis revealed that only fractions containing the tri- and tetra-flavonoid glycosides 1 and 3 caused significant increase of gastric volume and pH, thus indicating that these glycosides play an important role on the gastroprotective effect of M.ilicifolia leaves.Sociedade Brasileira de Química2010-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532010000200009Journal of the Brazilian Chemical Society v.21 n.2 2010reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532010000200009info:eu-repo/semantics/openAccessLeite,João Paulo V.Braga,Fernão C.Romussi,GiovanniPersoli,Rita M.Tabach,RicardoCarlini,Elisaldo A.Oliveira,Alaíde B.eng2010-03-16T00:00:00Zoai:scielo:S0103-50532010000200009Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2010-03-16T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Constituents from Maytenus ilicifolia leaves and bioguided fractionation for gastroprotective activity
title Constituents from Maytenus ilicifolia leaves and bioguided fractionation for gastroprotective activity
spellingShingle Constituents from Maytenus ilicifolia leaves and bioguided fractionation for gastroprotective activity
Leite,João Paulo V.
Maytenus ilicifolia
flavonoid glycosides
gastroprotective activity
liquid chromatography
title_short Constituents from Maytenus ilicifolia leaves and bioguided fractionation for gastroprotective activity
title_full Constituents from Maytenus ilicifolia leaves and bioguided fractionation for gastroprotective activity
title_fullStr Constituents from Maytenus ilicifolia leaves and bioguided fractionation for gastroprotective activity
title_full_unstemmed Constituents from Maytenus ilicifolia leaves and bioguided fractionation for gastroprotective activity
title_sort Constituents from Maytenus ilicifolia leaves and bioguided fractionation for gastroprotective activity
author Leite,João Paulo V.
author_facet Leite,João Paulo V.
Braga,Fernão C.
Romussi,Giovanni
Persoli,Rita M.
Tabach,Ricardo
Carlini,Elisaldo A.
Oliveira,Alaíde B.
author_role author
author2 Braga,Fernão C.
Romussi,Giovanni
Persoli,Rita M.
Tabach,Ricardo
Carlini,Elisaldo A.
Oliveira,Alaíde B.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Leite,João Paulo V.
Braga,Fernão C.
Romussi,Giovanni
Persoli,Rita M.
Tabach,Ricardo
Carlini,Elisaldo A.
Oliveira,Alaíde B.
dc.subject.por.fl_str_mv Maytenus ilicifolia
flavonoid glycosides
gastroprotective activity
liquid chromatography
topic Maytenus ilicifolia
flavonoid glycosides
gastroprotective activity
liquid chromatography
description Maytenus ilicifolia Mart. ex Reissek is traditionally used in Brazil for treatment of gastric ulcers. Here we report the phytochemical investigation of an ethanol extract of M. ilicifolia leaves (EEMIL) aiming at the isolation of constituents which were used as chemical markers to monitor an activity-guided fractionation of a lyophilized aqueous extract of M. ilicifolia leaves (LAEMIL). From EEMIL, four flavonoids were isolated, namely the tri-flavonoid glycosides mauritianin (1), trifolin, (2) hyperin (4), and epi-catechin (5). Fractionation of LAEMIL led to 5 fractions which afforded the tetra-glycoside kaempferol derivative (3), and galactitol (6). LAEMIL and its fractions were evaluated in rats for their effects on gastric secretion volume and pH. HPLC (High Performance Liquid Chromatography) analysis revealed that only fractions containing the tri- and tetra-flavonoid glycosides 1 and 3 caused significant increase of gastric volume and pH, thus indicating that these glycosides play an important role on the gastroprotective effect of M.ilicifolia leaves.
publishDate 2010
dc.date.none.fl_str_mv 2010-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532010000200009
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532010000200009
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-50532010000200009
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.21 n.2 2010
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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