Antifungal activity of natural and synthetic amides from Piper species

Detalhes bibliográficos
Autor(a) principal: Marques,Joaquim V.
Data de Publicação: 2010
Outros Autores: Oliveira,Alberto de, Raggi,Ludmila, Young,Maria C. M., Kato,Massuo J.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532010001000003
Resumo: The antifungal leaves extract from Piper scutifolium was submitted to bioactivity-guided chromatographic separation against Cladosporium cladosporioides and C. sphaerospermum yielding piperine, piperlonguminine and corcovadine as the active principles which displayed a detection limit of 1 µg. Structure-activity relationships were investigated with the preparation of twelve analogs having differences in the number of unsaturations, aromatic ring substituents and in the amide moiety. Analogs having a single double-bond and no substituent in the aromatic ring displayed higher activity, while N,N,-diethyl analogs displayed higher dose-dependent activity.
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spelling Antifungal activity of natural and synthetic amides from Piper speciesPiperantifungalanalogsamidesThe antifungal leaves extract from Piper scutifolium was submitted to bioactivity-guided chromatographic separation against Cladosporium cladosporioides and C. sphaerospermum yielding piperine, piperlonguminine and corcovadine as the active principles which displayed a detection limit of 1 µg. Structure-activity relationships were investigated with the preparation of twelve analogs having differences in the number of unsaturations, aromatic ring substituents and in the amide moiety. Analogs having a single double-bond and no substituent in the aromatic ring displayed higher activity, while N,N,-diethyl analogs displayed higher dose-dependent activity.Sociedade Brasileira de Química2010-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532010001000003Journal of the Brazilian Chemical Society v.21 n.10 2010reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532010001000003info:eu-repo/semantics/openAccessMarques,Joaquim V.Oliveira,Alberto deRaggi,LudmilaYoung,Maria C. M.Kato,Massuo J.eng2010-12-01T00:00:00Zoai:scielo:S0103-50532010001000003Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2010-12-01T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Antifungal activity of natural and synthetic amides from Piper species
title Antifungal activity of natural and synthetic amides from Piper species
spellingShingle Antifungal activity of natural and synthetic amides from Piper species
Marques,Joaquim V.
Piper
antifungal
analogs
amides
title_short Antifungal activity of natural and synthetic amides from Piper species
title_full Antifungal activity of natural and synthetic amides from Piper species
title_fullStr Antifungal activity of natural and synthetic amides from Piper species
title_full_unstemmed Antifungal activity of natural and synthetic amides from Piper species
title_sort Antifungal activity of natural and synthetic amides from Piper species
author Marques,Joaquim V.
author_facet Marques,Joaquim V.
Oliveira,Alberto de
Raggi,Ludmila
Young,Maria C. M.
Kato,Massuo J.
author_role author
author2 Oliveira,Alberto de
Raggi,Ludmila
Young,Maria C. M.
Kato,Massuo J.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Marques,Joaquim V.
Oliveira,Alberto de
Raggi,Ludmila
Young,Maria C. M.
Kato,Massuo J.
dc.subject.por.fl_str_mv Piper
antifungal
analogs
amides
topic Piper
antifungal
analogs
amides
description The antifungal leaves extract from Piper scutifolium was submitted to bioactivity-guided chromatographic separation against Cladosporium cladosporioides and C. sphaerospermum yielding piperine, piperlonguminine and corcovadine as the active principles which displayed a detection limit of 1 µg. Structure-activity relationships were investigated with the preparation of twelve analogs having differences in the number of unsaturations, aromatic ring substituents and in the amide moiety. Analogs having a single double-bond and no substituent in the aromatic ring displayed higher activity, while N,N,-diethyl analogs displayed higher dose-dependent activity.
publishDate 2010
dc.date.none.fl_str_mv 2010-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532010001000003
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532010001000003
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-50532010001000003
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.21 n.10 2010
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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