Photochemical and Electrochemical Study of the Release of Nitric Oxide from [Ru(bpy)2L(NO)](PF6)n Complexes (L = Imidazole, 1-Methylimidazole, Sulfite and Thiourea), Toward the Development of Therapeutic Photodynamic Agents

Detalhes bibliográficos
Autor(a) principal: Cândido,Manuela C. L.
Data de Publicação: 2015
Outros Autores: Oliveira,Arquimedes M., Silva,Francisco O. N., Holanda,Alda K. M., Pereira,Walysson Gomes, Sousa,Eduardo H. S., Carneiro,Zumira A., Silva,Roberto S., Lopes,Luiz G. F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532015000901824
Resumo: The development of NO photoreleaser compounds has important potential applications on medicine, particularly on preventing topic infections and controlling cancers. Due to these expectations, the photochemical release of nitric oxide from complexes of [Ru(bpy)2LX]n+, where L = imidazole, 1-methylimidazole, sulphite and thiourea and X = NO+ and NO2− was investigated employing spectroscopic and electrochemical techniques. The release of NO was confirmed by chronoamperometry using a NO selective electrode, while the other product, mainly [RuIIH2O], was detected by UV-Visible spectroscopy and electrochemical techniques for all complexes except for thiourea. The amount of NO released by these complexes upon irradiation was determined using a new developed method using square wave voltammetry.
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spelling Photochemical and Electrochemical Study of the Release of Nitric Oxide from [Ru(bpy)2L(NO)](PF6)n Complexes (L = Imidazole, 1-Methylimidazole, Sulfite and Thiourea), Toward the Development of Therapeutic Photodynamic Agentsruthenium nitrosyl complexesphotochemicalphotodynamic therapymetallodrugThe development of NO photoreleaser compounds has important potential applications on medicine, particularly on preventing topic infections and controlling cancers. Due to these expectations, the photochemical release of nitric oxide from complexes of [Ru(bpy)2LX]n+, where L = imidazole, 1-methylimidazole, sulphite and thiourea and X = NO+ and NO2− was investigated employing spectroscopic and electrochemical techniques. The release of NO was confirmed by chronoamperometry using a NO selective electrode, while the other product, mainly [RuIIH2O], was detected by UV-Visible spectroscopy and electrochemical techniques for all complexes except for thiourea. The amount of NO released by these complexes upon irradiation was determined using a new developed method using square wave voltammetry.Sociedade Brasileira de Química2015-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532015000901824Journal of the Brazilian Chemical Society v.26 n.9 2015reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.5935/0103-5053.20150159info:eu-repo/semantics/openAccessCândido,Manuela C. L.Oliveira,Arquimedes M.Silva,Francisco O. N.Holanda,Alda K. M.Pereira,Walysson GomesSousa,Eduardo H. S.Carneiro,Zumira A.Silva,Roberto S.Lopes,Luiz G. F.eng2015-09-11T00:00:00Zoai:scielo:S0103-50532015000901824Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2015-09-11T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Photochemical and Electrochemical Study of the Release of Nitric Oxide from [Ru(bpy)2L(NO)](PF6)n Complexes (L = Imidazole, 1-Methylimidazole, Sulfite and Thiourea), Toward the Development of Therapeutic Photodynamic Agents
title Photochemical and Electrochemical Study of the Release of Nitric Oxide from [Ru(bpy)2L(NO)](PF6)n Complexes (L = Imidazole, 1-Methylimidazole, Sulfite and Thiourea), Toward the Development of Therapeutic Photodynamic Agents
spellingShingle Photochemical and Electrochemical Study of the Release of Nitric Oxide from [Ru(bpy)2L(NO)](PF6)n Complexes (L = Imidazole, 1-Methylimidazole, Sulfite and Thiourea), Toward the Development of Therapeutic Photodynamic Agents
Cândido,Manuela C. L.
ruthenium nitrosyl complexes
photochemical
photodynamic therapy
metallodrug
title_short Photochemical and Electrochemical Study of the Release of Nitric Oxide from [Ru(bpy)2L(NO)](PF6)n Complexes (L = Imidazole, 1-Methylimidazole, Sulfite and Thiourea), Toward the Development of Therapeutic Photodynamic Agents
title_full Photochemical and Electrochemical Study of the Release of Nitric Oxide from [Ru(bpy)2L(NO)](PF6)n Complexes (L = Imidazole, 1-Methylimidazole, Sulfite and Thiourea), Toward the Development of Therapeutic Photodynamic Agents
title_fullStr Photochemical and Electrochemical Study of the Release of Nitric Oxide from [Ru(bpy)2L(NO)](PF6)n Complexes (L = Imidazole, 1-Methylimidazole, Sulfite and Thiourea), Toward the Development of Therapeutic Photodynamic Agents
title_full_unstemmed Photochemical and Electrochemical Study of the Release of Nitric Oxide from [Ru(bpy)2L(NO)](PF6)n Complexes (L = Imidazole, 1-Methylimidazole, Sulfite and Thiourea), Toward the Development of Therapeutic Photodynamic Agents
title_sort Photochemical and Electrochemical Study of the Release of Nitric Oxide from [Ru(bpy)2L(NO)](PF6)n Complexes (L = Imidazole, 1-Methylimidazole, Sulfite and Thiourea), Toward the Development of Therapeutic Photodynamic Agents
author Cândido,Manuela C. L.
author_facet Cândido,Manuela C. L.
Oliveira,Arquimedes M.
Silva,Francisco O. N.
Holanda,Alda K. M.
Pereira,Walysson Gomes
Sousa,Eduardo H. S.
Carneiro,Zumira A.
Silva,Roberto S.
Lopes,Luiz G. F.
author_role author
author2 Oliveira,Arquimedes M.
Silva,Francisco O. N.
Holanda,Alda K. M.
Pereira,Walysson Gomes
Sousa,Eduardo H. S.
Carneiro,Zumira A.
Silva,Roberto S.
Lopes,Luiz G. F.
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Cândido,Manuela C. L.
Oliveira,Arquimedes M.
Silva,Francisco O. N.
Holanda,Alda K. M.
Pereira,Walysson Gomes
Sousa,Eduardo H. S.
Carneiro,Zumira A.
Silva,Roberto S.
Lopes,Luiz G. F.
dc.subject.por.fl_str_mv ruthenium nitrosyl complexes
photochemical
photodynamic therapy
metallodrug
topic ruthenium nitrosyl complexes
photochemical
photodynamic therapy
metallodrug
description The development of NO photoreleaser compounds has important potential applications on medicine, particularly on preventing topic infections and controlling cancers. Due to these expectations, the photochemical release of nitric oxide from complexes of [Ru(bpy)2LX]n+, where L = imidazole, 1-methylimidazole, sulphite and thiourea and X = NO+ and NO2− was investigated employing spectroscopic and electrochemical techniques. The release of NO was confirmed by chronoamperometry using a NO selective electrode, while the other product, mainly [RuIIH2O], was detected by UV-Visible spectroscopy and electrochemical techniques for all complexes except for thiourea. The amount of NO released by these complexes upon irradiation was determined using a new developed method using square wave voltammetry.
publishDate 2015
dc.date.none.fl_str_mv 2015-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532015000901824
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532015000901824
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/0103-5053.20150159
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.26 n.9 2015
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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