Synthesis and antiacetylcholinesterase activity of new D-glyceraldehyde heterocyclic derivatives

Detalhes bibliográficos
Autor(a) principal: Scorzo,Cecilia M.
Data de Publicação: 2010
Outros Autores: Fascio,Mirta L., D'Accorso,Norma B., Cabrera,Margarita Gutiérrez, Saavedra,Luís Astudillo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532010000100008
Resumo: We report herein the convenient procedures for the syntheses of different heterocyclic compounds from 2,3-O-isopropylidene-D-glyceraldehyde using intramolecular cyclization, 1,3-dipolar cycloaddition or bimolecular coupling reactions. The products were characterized by ¹H and 13C NMR spectroscopy and elemental analysis. The new heterocycles and their derivatives were evaluated as inhibitors of acetylcholinesterase enzyme.
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spelling Synthesis and antiacetylcholinesterase activity of new D-glyceraldehyde heterocyclic derivativesD-glyceraldehydeheterocyclic compoundscycloadditionacetylcholinesteraseAlzheimer´s diseaseWe report herein the convenient procedures for the syntheses of different heterocyclic compounds from 2,3-O-isopropylidene-D-glyceraldehyde using intramolecular cyclization, 1,3-dipolar cycloaddition or bimolecular coupling reactions. The products were characterized by ¹H and 13C NMR spectroscopy and elemental analysis. The new heterocycles and their derivatives were evaluated as inhibitors of acetylcholinesterase enzyme.Sociedade Brasileira de Química2010-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532010000100008Journal of the Brazilian Chemical Society v.21 n.1 2010reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532010000100008info:eu-repo/semantics/openAccessScorzo,Cecilia M.Fascio,Mirta L.D'Accorso,Norma B.Cabrera,Margarita GutiérrezSaavedra,Luís Astudilloeng2010-02-18T00:00:00Zoai:scielo:S0103-50532010000100008Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2010-02-18T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Synthesis and antiacetylcholinesterase activity of new D-glyceraldehyde heterocyclic derivatives
title Synthesis and antiacetylcholinesterase activity of new D-glyceraldehyde heterocyclic derivatives
spellingShingle Synthesis and antiacetylcholinesterase activity of new D-glyceraldehyde heterocyclic derivatives
Scorzo,Cecilia M.
D-glyceraldehyde
heterocyclic compounds
cycloaddition
acetylcholinesterase
Alzheimer´s disease
title_short Synthesis and antiacetylcholinesterase activity of new D-glyceraldehyde heterocyclic derivatives
title_full Synthesis and antiacetylcholinesterase activity of new D-glyceraldehyde heterocyclic derivatives
title_fullStr Synthesis and antiacetylcholinesterase activity of new D-glyceraldehyde heterocyclic derivatives
title_full_unstemmed Synthesis and antiacetylcholinesterase activity of new D-glyceraldehyde heterocyclic derivatives
title_sort Synthesis and antiacetylcholinesterase activity of new D-glyceraldehyde heterocyclic derivatives
author Scorzo,Cecilia M.
author_facet Scorzo,Cecilia M.
Fascio,Mirta L.
D'Accorso,Norma B.
Cabrera,Margarita Gutiérrez
Saavedra,Luís Astudillo
author_role author
author2 Fascio,Mirta L.
D'Accorso,Norma B.
Cabrera,Margarita Gutiérrez
Saavedra,Luís Astudillo
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Scorzo,Cecilia M.
Fascio,Mirta L.
D'Accorso,Norma B.
Cabrera,Margarita Gutiérrez
Saavedra,Luís Astudillo
dc.subject.por.fl_str_mv D-glyceraldehyde
heterocyclic compounds
cycloaddition
acetylcholinesterase
Alzheimer´s disease
topic D-glyceraldehyde
heterocyclic compounds
cycloaddition
acetylcholinesterase
Alzheimer´s disease
description We report herein the convenient procedures for the syntheses of different heterocyclic compounds from 2,3-O-isopropylidene-D-glyceraldehyde using intramolecular cyclization, 1,3-dipolar cycloaddition or bimolecular coupling reactions. The products were characterized by ¹H and 13C NMR spectroscopy and elemental analysis. The new heterocycles and their derivatives were evaluated as inhibitors of acetylcholinesterase enzyme.
publishDate 2010
dc.date.none.fl_str_mv 2010-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532010000100008
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532010000100008
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-50532010000100008
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.21 n.1 2010
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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