Synthesis and characterization of new amino acyl-4-thiazolidones

Detalhes bibliográficos
Autor(a) principal: Leite,Ana Cristina Lima
Data de Publicação: 2007
Outros Autores: Santos,Luciene Maria F., Moreira,Diogo Rodrigo de M., Brondani,Dalci José
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422007000200008
Resumo: A series of heterocyclic compounds with a 4-thiazolidone nucleus and amino acyl moiety were synthesized by protection reaction of thiosemicarbazide using the symmetrical anhydride (Boc)2O and cyclization with chloroacetic acid under mild conditions. Trifluoroacetic acid was used to obtain 4-thiazolidone and the alpha-amino acid condensation reactions were carried out using strategies for peptide synthesis. The characterization of this new class of compounds was performed using IR and ¹H-NMR spectroscopy.
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spelling Synthesis and characterization of new amino acyl-4-thiazolidones4-thiazolidonepeptidyl derivativesheterocyclic compoundsA series of heterocyclic compounds with a 4-thiazolidone nucleus and amino acyl moiety were synthesized by protection reaction of thiosemicarbazide using the symmetrical anhydride (Boc)2O and cyclization with chloroacetic acid under mild conditions. Trifluoroacetic acid was used to obtain 4-thiazolidone and the alpha-amino acid condensation reactions were carried out using strategies for peptide synthesis. The characterization of this new class of compounds was performed using IR and ¹H-NMR spectroscopy.Sociedade Brasileira de Química2007-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422007000200008Química Nova v.30 n.2 2007reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422007000200008info:eu-repo/semantics/openAccessLeite,Ana Cristina LimaSantos,Luciene Maria F.Moreira,Diogo Rodrigo de M.Brondani,Dalci Joséeng2007-03-13T00:00:00Zoai:scielo:S0100-40422007000200008Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2007-03-13T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Synthesis and characterization of new amino acyl-4-thiazolidones
title Synthesis and characterization of new amino acyl-4-thiazolidones
spellingShingle Synthesis and characterization of new amino acyl-4-thiazolidones
Leite,Ana Cristina Lima
4-thiazolidone
peptidyl derivatives
heterocyclic compounds
title_short Synthesis and characterization of new amino acyl-4-thiazolidones
title_full Synthesis and characterization of new amino acyl-4-thiazolidones
title_fullStr Synthesis and characterization of new amino acyl-4-thiazolidones
title_full_unstemmed Synthesis and characterization of new amino acyl-4-thiazolidones
title_sort Synthesis and characterization of new amino acyl-4-thiazolidones
author Leite,Ana Cristina Lima
author_facet Leite,Ana Cristina Lima
Santos,Luciene Maria F.
Moreira,Diogo Rodrigo de M.
Brondani,Dalci José
author_role author
author2 Santos,Luciene Maria F.
Moreira,Diogo Rodrigo de M.
Brondani,Dalci José
author2_role author
author
author
dc.contributor.author.fl_str_mv Leite,Ana Cristina Lima
Santos,Luciene Maria F.
Moreira,Diogo Rodrigo de M.
Brondani,Dalci José
dc.subject.por.fl_str_mv 4-thiazolidone
peptidyl derivatives
heterocyclic compounds
topic 4-thiazolidone
peptidyl derivatives
heterocyclic compounds
description A series of heterocyclic compounds with a 4-thiazolidone nucleus and amino acyl moiety were synthesized by protection reaction of thiosemicarbazide using the symmetrical anhydride (Boc)2O and cyclization with chloroacetic acid under mild conditions. Trifluoroacetic acid was used to obtain 4-thiazolidone and the alpha-amino acid condensation reactions were carried out using strategies for peptide synthesis. The characterization of this new class of compounds was performed using IR and ¹H-NMR spectroscopy.
publishDate 2007
dc.date.none.fl_str_mv 2007-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422007000200008
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422007000200008
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-40422007000200008
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.30 n.2 2007
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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