Three new triterpenes from the resinous bark of Protium kleinii and their antinociceptive activity
Autor(a) principal: | |
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Data de Publicação: | 2005 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of the Brazilian Chemical Society (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532005000400014 |
Resumo: | Three novel pentacyclic triterpenes have been isolated from the resin of Protium kleinii and their structures elucidated by NMR spectroscopy as 3-oxo-11beta,16beta-dihydroxy-urs-12-ene (1), 3-oxo-11beta-hydroxy-urs-12-ene (2) and 3-oxo-11beta-hydroxy-olean-12-ene (3). The systemic administration of the above compounds (10-100 mg kg-1, i.p.) was able to inhibited both first and second phase of the formalin-induced nociception in mice. The known triterpenes 3beta,16beta-dihydroxy-olean-12-ene (brein) (4) and a mixture of alpha (5)- and beta-amyrin (6) were also found. |
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Three new triterpenes from the resinous bark of Protium kleinii and their antinociceptive activityProtium kleiniiBurseraceaepentacyclic triterpenesantinociceptive activityThree novel pentacyclic triterpenes have been isolated from the resin of Protium kleinii and their structures elucidated by NMR spectroscopy as 3-oxo-11beta,16beta-dihydroxy-urs-12-ene (1), 3-oxo-11beta-hydroxy-urs-12-ene (2) and 3-oxo-11beta-hydroxy-olean-12-ene (3). The systemic administration of the above compounds (10-100 mg kg-1, i.p.) was able to inhibited both first and second phase of the formalin-induced nociception in mice. The known triterpenes 3beta,16beta-dihydroxy-olean-12-ene (brein) (4) and a mixture of alpha (5)- and beta-amyrin (6) were also found.Sociedade Brasileira de Química2005-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532005000400014Journal of the Brazilian Chemical Society v.16 n.3b 2005reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532005000400014info:eu-repo/semantics/openAccessLima,Fabiana V.Malheiros,AngelaOtuki,Michel F.Calixto,João B.Yunes,Rosendo A.Cechinel Filho,ValdirDelle Monache,Francoeng2005-08-09T00:00:00Zoai:scielo:S0103-50532005000400014Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2005-08-09T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
Three new triterpenes from the resinous bark of Protium kleinii and their antinociceptive activity |
title |
Three new triterpenes from the resinous bark of Protium kleinii and their antinociceptive activity |
spellingShingle |
Three new triterpenes from the resinous bark of Protium kleinii and their antinociceptive activity Lima,Fabiana V. Protium kleinii Burseraceae pentacyclic triterpenes antinociceptive activity |
title_short |
Three new triterpenes from the resinous bark of Protium kleinii and their antinociceptive activity |
title_full |
Three new triterpenes from the resinous bark of Protium kleinii and their antinociceptive activity |
title_fullStr |
Three new triterpenes from the resinous bark of Protium kleinii and their antinociceptive activity |
title_full_unstemmed |
Three new triterpenes from the resinous bark of Protium kleinii and their antinociceptive activity |
title_sort |
Three new triterpenes from the resinous bark of Protium kleinii and their antinociceptive activity |
author |
Lima,Fabiana V. |
author_facet |
Lima,Fabiana V. Malheiros,Angela Otuki,Michel F. Calixto,João B. Yunes,Rosendo A. Cechinel Filho,Valdir Delle Monache,Franco |
author_role |
author |
author2 |
Malheiros,Angela Otuki,Michel F. Calixto,João B. Yunes,Rosendo A. Cechinel Filho,Valdir Delle Monache,Franco |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Lima,Fabiana V. Malheiros,Angela Otuki,Michel F. Calixto,João B. Yunes,Rosendo A. Cechinel Filho,Valdir Delle Monache,Franco |
dc.subject.por.fl_str_mv |
Protium kleinii Burseraceae pentacyclic triterpenes antinociceptive activity |
topic |
Protium kleinii Burseraceae pentacyclic triterpenes antinociceptive activity |
description |
Three novel pentacyclic triterpenes have been isolated from the resin of Protium kleinii and their structures elucidated by NMR spectroscopy as 3-oxo-11beta,16beta-dihydroxy-urs-12-ene (1), 3-oxo-11beta-hydroxy-urs-12-ene (2) and 3-oxo-11beta-hydroxy-olean-12-ene (3). The systemic administration of the above compounds (10-100 mg kg-1, i.p.) was able to inhibited both first and second phase of the formalin-induced nociception in mice. The known triterpenes 3beta,16beta-dihydroxy-olean-12-ene (brein) (4) and a mixture of alpha (5)- and beta-amyrin (6) were also found. |
publishDate |
2005 |
dc.date.none.fl_str_mv |
2005-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532005000400014 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532005000400014 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0103-50532005000400014 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Journal of the Brazilian Chemical Society v.16 n.3b 2005 reponame:Journal of the Brazilian Chemical Society (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Journal of the Brazilian Chemical Society (Online) |
collection |
Journal of the Brazilian Chemical Society (Online) |
repository.name.fl_str_mv |
Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
||office@jbcs.sbq.org.br |
_version_ |
1750318166220734464 |