Three new triterpenes from the resinous bark of Protium kleinii and their antinociceptive activity

Detalhes bibliográficos
Autor(a) principal: Lima,Fabiana V.
Data de Publicação: 2005
Outros Autores: Malheiros,Angela, Otuki,Michel F., Calixto,João B., Yunes,Rosendo A., Cechinel Filho,Valdir, Delle Monache,Franco
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532005000400014
Resumo: Three novel pentacyclic triterpenes have been isolated from the resin of Protium kleinii and their structures elucidated by NMR spectroscopy as 3-oxo-11beta,16beta-dihydroxy-urs-12-ene (1), 3-oxo-11beta-hydroxy-urs-12-ene (2) and 3-oxo-11beta-hydroxy-olean-12-ene (3). The systemic administration of the above compounds (10-100 mg kg-1, i.p.) was able to inhibited both first and second phase of the formalin-induced nociception in mice. The known triterpenes 3beta,16beta-dihydroxy-olean-12-ene (brein) (4) and a mixture of alpha (5)- and beta-amyrin (6) were also found.
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spelling Three new triterpenes from the resinous bark of Protium kleinii and their antinociceptive activityProtium kleiniiBurseraceaepentacyclic triterpenesantinociceptive activityThree novel pentacyclic triterpenes have been isolated from the resin of Protium kleinii and their structures elucidated by NMR spectroscopy as 3-oxo-11beta,16beta-dihydroxy-urs-12-ene (1), 3-oxo-11beta-hydroxy-urs-12-ene (2) and 3-oxo-11beta-hydroxy-olean-12-ene (3). The systemic administration of the above compounds (10-100 mg kg-1, i.p.) was able to inhibited both first and second phase of the formalin-induced nociception in mice. The known triterpenes 3beta,16beta-dihydroxy-olean-12-ene (brein) (4) and a mixture of alpha (5)- and beta-amyrin (6) were also found.Sociedade Brasileira de Química2005-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532005000400014Journal of the Brazilian Chemical Society v.16 n.3b 2005reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532005000400014info:eu-repo/semantics/openAccessLima,Fabiana V.Malheiros,AngelaOtuki,Michel F.Calixto,João B.Yunes,Rosendo A.Cechinel Filho,ValdirDelle Monache,Francoeng2005-08-09T00:00:00Zoai:scielo:S0103-50532005000400014Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2005-08-09T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Three new triterpenes from the resinous bark of Protium kleinii and their antinociceptive activity
title Three new triterpenes from the resinous bark of Protium kleinii and their antinociceptive activity
spellingShingle Three new triterpenes from the resinous bark of Protium kleinii and their antinociceptive activity
Lima,Fabiana V.
Protium kleinii
Burseraceae
pentacyclic triterpenes
antinociceptive activity
title_short Three new triterpenes from the resinous bark of Protium kleinii and their antinociceptive activity
title_full Three new triterpenes from the resinous bark of Protium kleinii and their antinociceptive activity
title_fullStr Three new triterpenes from the resinous bark of Protium kleinii and their antinociceptive activity
title_full_unstemmed Three new triterpenes from the resinous bark of Protium kleinii and their antinociceptive activity
title_sort Three new triterpenes from the resinous bark of Protium kleinii and their antinociceptive activity
author Lima,Fabiana V.
author_facet Lima,Fabiana V.
Malheiros,Angela
Otuki,Michel F.
Calixto,João B.
Yunes,Rosendo A.
Cechinel Filho,Valdir
Delle Monache,Franco
author_role author
author2 Malheiros,Angela
Otuki,Michel F.
Calixto,João B.
Yunes,Rosendo A.
Cechinel Filho,Valdir
Delle Monache,Franco
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Lima,Fabiana V.
Malheiros,Angela
Otuki,Michel F.
Calixto,João B.
Yunes,Rosendo A.
Cechinel Filho,Valdir
Delle Monache,Franco
dc.subject.por.fl_str_mv Protium kleinii
Burseraceae
pentacyclic triterpenes
antinociceptive activity
topic Protium kleinii
Burseraceae
pentacyclic triterpenes
antinociceptive activity
description Three novel pentacyclic triterpenes have been isolated from the resin of Protium kleinii and their structures elucidated by NMR spectroscopy as 3-oxo-11beta,16beta-dihydroxy-urs-12-ene (1), 3-oxo-11beta-hydroxy-urs-12-ene (2) and 3-oxo-11beta-hydroxy-olean-12-ene (3). The systemic administration of the above compounds (10-100 mg kg-1, i.p.) was able to inhibited both first and second phase of the formalin-induced nociception in mice. The known triterpenes 3beta,16beta-dihydroxy-olean-12-ene (brein) (4) and a mixture of alpha (5)- and beta-amyrin (6) were also found.
publishDate 2005
dc.date.none.fl_str_mv 2005-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532005000400014
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532005000400014
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-50532005000400014
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.16 n.3b 2005
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
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instname_str Sociedade Brasileira de Química (SBQ)
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reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
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