Thiazolidin-4-ones from 3-(Aminomethyl)pyridine, Arenealdehydes and Mercaptoacetic Acid: Synthesis and Radical Scavenger Activity

Detalhes bibliográficos
Autor(a) principal: Neves,Adriana M.
Data de Publicação: 2015
Outros Autores: Duval,Auri R., Berwaldt,Gabriele A., Gouvêa,Daniela P., Flores,Natália P., Silva,Pâmela G. da, Stefanello,Francieli M., Cunico,Wilson
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532015000200381
Resumo: The efficient synthesis of fifteen novel thiazolidin-4-ones from reaction of 3-(aminomethyl) pyridine (3-picolylamine), arenealdenhydes and mercaptoacetic acid was described. The desired compounds were obtained in moderated to good yields by two methodologies: conventional heating and ultrasound irradiation. The thiazolidin-4-ones were fully identified and characterized by nuclear magnetic resonance (NMR), gas chromatography coupled to mass spectrometry (GC‑MS) and high resolution mass spectrometry (HRMS) techniques. Four compounds showed radical scavenger activity in the 2,2’-azinobis-3-ethyl-benzothiazoline-6-sulfonic acid (ABTS) assay.
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spelling Thiazolidin-4-ones from 3-(Aminomethyl)pyridine, Arenealdehydes and Mercaptoacetic Acid: Synthesis and Radical Scavenger Activitythiazolidin-4-onespicolylaminesonochemistryradicalThe efficient synthesis of fifteen novel thiazolidin-4-ones from reaction of 3-(aminomethyl) pyridine (3-picolylamine), arenealdenhydes and mercaptoacetic acid was described. The desired compounds were obtained in moderated to good yields by two methodologies: conventional heating and ultrasound irradiation. The thiazolidin-4-ones were fully identified and characterized by nuclear magnetic resonance (NMR), gas chromatography coupled to mass spectrometry (GC‑MS) and high resolution mass spectrometry (HRMS) techniques. Four compounds showed radical scavenger activity in the 2,2’-azinobis-3-ethyl-benzothiazoline-6-sulfonic acid (ABTS) assay.Sociedade Brasileira de Química2015-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532015000200381Journal of the Brazilian Chemical Society v.26 n.2 2015reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.5935/0103-5053.20140291info:eu-repo/semantics/openAccessNeves,Adriana M.Duval,Auri R.Berwaldt,Gabriele A.Gouvêa,Daniela P.Flores,Natália P.Silva,Pâmela G. daStefanello,Francieli M.Cunico,Wilsoneng2015-10-26T00:00:00Zoai:scielo:S0103-50532015000200381Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2015-10-26T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Thiazolidin-4-ones from 3-(Aminomethyl)pyridine, Arenealdehydes and Mercaptoacetic Acid: Synthesis and Radical Scavenger Activity
title Thiazolidin-4-ones from 3-(Aminomethyl)pyridine, Arenealdehydes and Mercaptoacetic Acid: Synthesis and Radical Scavenger Activity
spellingShingle Thiazolidin-4-ones from 3-(Aminomethyl)pyridine, Arenealdehydes and Mercaptoacetic Acid: Synthesis and Radical Scavenger Activity
Neves,Adriana M.
thiazolidin-4-ones
picolylamine
sonochemistry
radical
title_short Thiazolidin-4-ones from 3-(Aminomethyl)pyridine, Arenealdehydes and Mercaptoacetic Acid: Synthesis and Radical Scavenger Activity
title_full Thiazolidin-4-ones from 3-(Aminomethyl)pyridine, Arenealdehydes and Mercaptoacetic Acid: Synthesis and Radical Scavenger Activity
title_fullStr Thiazolidin-4-ones from 3-(Aminomethyl)pyridine, Arenealdehydes and Mercaptoacetic Acid: Synthesis and Radical Scavenger Activity
title_full_unstemmed Thiazolidin-4-ones from 3-(Aminomethyl)pyridine, Arenealdehydes and Mercaptoacetic Acid: Synthesis and Radical Scavenger Activity
title_sort Thiazolidin-4-ones from 3-(Aminomethyl)pyridine, Arenealdehydes and Mercaptoacetic Acid: Synthesis and Radical Scavenger Activity
author Neves,Adriana M.
author_facet Neves,Adriana M.
Duval,Auri R.
Berwaldt,Gabriele A.
Gouvêa,Daniela P.
Flores,Natália P.
Silva,Pâmela G. da
Stefanello,Francieli M.
Cunico,Wilson
author_role author
author2 Duval,Auri R.
Berwaldt,Gabriele A.
Gouvêa,Daniela P.
Flores,Natália P.
Silva,Pâmela G. da
Stefanello,Francieli M.
Cunico,Wilson
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Neves,Adriana M.
Duval,Auri R.
Berwaldt,Gabriele A.
Gouvêa,Daniela P.
Flores,Natália P.
Silva,Pâmela G. da
Stefanello,Francieli M.
Cunico,Wilson
dc.subject.por.fl_str_mv thiazolidin-4-ones
picolylamine
sonochemistry
radical
topic thiazolidin-4-ones
picolylamine
sonochemistry
radical
description The efficient synthesis of fifteen novel thiazolidin-4-ones from reaction of 3-(aminomethyl) pyridine (3-picolylamine), arenealdenhydes and mercaptoacetic acid was described. The desired compounds were obtained in moderated to good yields by two methodologies: conventional heating and ultrasound irradiation. The thiazolidin-4-ones were fully identified and characterized by nuclear magnetic resonance (NMR), gas chromatography coupled to mass spectrometry (GC‑MS) and high resolution mass spectrometry (HRMS) techniques. Four compounds showed radical scavenger activity in the 2,2’-azinobis-3-ethyl-benzothiazoline-6-sulfonic acid (ABTS) assay.
publishDate 2015
dc.date.none.fl_str_mv 2015-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532015000200381
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532015000200381
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/0103-5053.20140291
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.26 n.2 2015
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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