Antioxidant Properties of Croton zehntneri Pax et Hoffm. Essential Oil and Its Inclusion Complex with β-Cyclodextrin Prepared by Spray Drying

Detalhes bibliográficos
Autor(a) principal: Sousa,Antônio J. P.
Data de Publicação: 2022
Outros Autores: Oliveira,George L. S., Fonseca,Lorenna, Rocha,Marcio S., Rai,Mahendra, Santos,Francisco E. P., Lima,Sidney G. de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532022001001244
Resumo: Croton zehntneri Pax et Hoffm. is a plant from Northeastern Brazil, whose main component of its essential oil is estragole. Its thermal instability and low aqueous solubility prevent its technological application. This study aimed to prepare and characterize the Croton zehntneri essential oil (CZEO) complexed with β-cyclodextrin (β-CD), and to evaluate antioxidant activity of free and complexed-CZEO in vitro systems by the elimination of 2,2-diphenyl-1-picrylhydrazyl radicals (DPPH•), 2,2’-azinobis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS•+), hydroxyl and nitric oxide, as well as their ability to transfer electrons by the reducing potential. The infrared spectroscopy and thermal techniques demonstrated the formation of the inclusion complex (Est/β-CD) obtained by spray drying method. The free CZEO and its Est/β-CD at 0.9, 1.8, 3.6, 7.2, 14.4 and 28.8 µg mL-1 showed the ability to remove DPPH• (EC50 (half maximal effective concentration) 26.06 and 9.46 µg mL-1, respectively) and ABTS•+ (EC50 22.73 and 4.47 µg mL-1, respectively), nitric oxide inhibition (EC50 17.65 and 2.68 µg mL-1, respectively), hydroxyl radical sequestration (EC50 23.42 and 2.34 µg mL-1, respectively) and reducing potential (EC50 46.48 and 12.47 µg mL-1, respectively). The formation of the inclusion complex significantly increases its antioxidant potential.
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spelling Antioxidant Properties of Croton zehntneri Pax et Hoffm. Essential Oil and Its Inclusion Complex with β-Cyclodextrin Prepared by Spray DryingCroton zehntneriestragoleβ-cyclodextrinantioxidant potentialCroton zehntneri Pax et Hoffm. is a plant from Northeastern Brazil, whose main component of its essential oil is estragole. Its thermal instability and low aqueous solubility prevent its technological application. This study aimed to prepare and characterize the Croton zehntneri essential oil (CZEO) complexed with β-cyclodextrin (β-CD), and to evaluate antioxidant activity of free and complexed-CZEO in vitro systems by the elimination of 2,2-diphenyl-1-picrylhydrazyl radicals (DPPH•), 2,2’-azinobis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS•+), hydroxyl and nitric oxide, as well as their ability to transfer electrons by the reducing potential. The infrared spectroscopy and thermal techniques demonstrated the formation of the inclusion complex (Est/β-CD) obtained by spray drying method. The free CZEO and its Est/β-CD at 0.9, 1.8, 3.6, 7.2, 14.4 and 28.8 µg mL-1 showed the ability to remove DPPH• (EC50 (half maximal effective concentration) 26.06 and 9.46 µg mL-1, respectively) and ABTS•+ (EC50 22.73 and 4.47 µg mL-1, respectively), nitric oxide inhibition (EC50 17.65 and 2.68 µg mL-1, respectively), hydroxyl radical sequestration (EC50 23.42 and 2.34 µg mL-1, respectively) and reducing potential (EC50 46.48 and 12.47 µg mL-1, respectively). The formation of the inclusion complex significantly increases its antioxidant potential.Sociedade Brasileira de Química2022-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532022001001244Journal of the Brazilian Chemical Society v.33 n.10 2022reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.21577/0103-5053.20220051info:eu-repo/semantics/openAccessSousa,Antônio J. P.Oliveira,George L. S.Fonseca,LorennaRocha,Marcio S.Rai,MahendraSantos,Francisco E. P.Lima,Sidney G. deeng2022-10-07T00:00:00Zoai:scielo:S0103-50532022001001244Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2022-10-07T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Antioxidant Properties of Croton zehntneri Pax et Hoffm. Essential Oil and Its Inclusion Complex with β-Cyclodextrin Prepared by Spray Drying
title Antioxidant Properties of Croton zehntneri Pax et Hoffm. Essential Oil and Its Inclusion Complex with β-Cyclodextrin Prepared by Spray Drying
spellingShingle Antioxidant Properties of Croton zehntneri Pax et Hoffm. Essential Oil and Its Inclusion Complex with β-Cyclodextrin Prepared by Spray Drying
Sousa,Antônio J. P.
Croton zehntneri
estragole
β-cyclodextrin
antioxidant potential
title_short Antioxidant Properties of Croton zehntneri Pax et Hoffm. Essential Oil and Its Inclusion Complex with β-Cyclodextrin Prepared by Spray Drying
title_full Antioxidant Properties of Croton zehntneri Pax et Hoffm. Essential Oil and Its Inclusion Complex with β-Cyclodextrin Prepared by Spray Drying
title_fullStr Antioxidant Properties of Croton zehntneri Pax et Hoffm. Essential Oil and Its Inclusion Complex with β-Cyclodextrin Prepared by Spray Drying
title_full_unstemmed Antioxidant Properties of Croton zehntneri Pax et Hoffm. Essential Oil and Its Inclusion Complex with β-Cyclodextrin Prepared by Spray Drying
title_sort Antioxidant Properties of Croton zehntneri Pax et Hoffm. Essential Oil and Its Inclusion Complex with β-Cyclodextrin Prepared by Spray Drying
author Sousa,Antônio J. P.
author_facet Sousa,Antônio J. P.
Oliveira,George L. S.
Fonseca,Lorenna
Rocha,Marcio S.
Rai,Mahendra
Santos,Francisco E. P.
Lima,Sidney G. de
author_role author
author2 Oliveira,George L. S.
Fonseca,Lorenna
Rocha,Marcio S.
Rai,Mahendra
Santos,Francisco E. P.
Lima,Sidney G. de
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Sousa,Antônio J. P.
Oliveira,George L. S.
Fonseca,Lorenna
Rocha,Marcio S.
Rai,Mahendra
Santos,Francisco E. P.
Lima,Sidney G. de
dc.subject.por.fl_str_mv Croton zehntneri
estragole
β-cyclodextrin
antioxidant potential
topic Croton zehntneri
estragole
β-cyclodextrin
antioxidant potential
description Croton zehntneri Pax et Hoffm. is a plant from Northeastern Brazil, whose main component of its essential oil is estragole. Its thermal instability and low aqueous solubility prevent its technological application. This study aimed to prepare and characterize the Croton zehntneri essential oil (CZEO) complexed with β-cyclodextrin (β-CD), and to evaluate antioxidant activity of free and complexed-CZEO in vitro systems by the elimination of 2,2-diphenyl-1-picrylhydrazyl radicals (DPPH•), 2,2’-azinobis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS•+), hydroxyl and nitric oxide, as well as their ability to transfer electrons by the reducing potential. The infrared spectroscopy and thermal techniques demonstrated the formation of the inclusion complex (Est/β-CD) obtained by spray drying method. The free CZEO and its Est/β-CD at 0.9, 1.8, 3.6, 7.2, 14.4 and 28.8 µg mL-1 showed the ability to remove DPPH• (EC50 (half maximal effective concentration) 26.06 and 9.46 µg mL-1, respectively) and ABTS•+ (EC50 22.73 and 4.47 µg mL-1, respectively), nitric oxide inhibition (EC50 17.65 and 2.68 µg mL-1, respectively), hydroxyl radical sequestration (EC50 23.42 and 2.34 µg mL-1, respectively) and reducing potential (EC50 46.48 and 12.47 µg mL-1, respectively). The formation of the inclusion complex significantly increases its antioxidant potential.
publishDate 2022
dc.date.none.fl_str_mv 2022-10-01
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dc.language.iso.fl_str_mv eng
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dc.relation.none.fl_str_mv 10.21577/0103-5053.20220051
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dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.33 n.10 2022
reponame:Journal of the Brazilian Chemical Society (Online)
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