Conducting polymer- hydrogel blends for electrochemically controlled drug release devices

Detalhes bibliográficos
Autor(a) principal: Barthus,Rosângela C.
Data de Publicação: 2008
Outros Autores: Lira,Luiz M., Torresi,Susana I. Córdoba de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532008000400004
Resumo: Blends formed by electrochemical polymerization of polypyrrole (PPy) into polyacrylamide (PAAm) hydrogels were used as devices for controlled drug release. The influence of several parameters in the synthesis, such as type of hydrogel matrix and polymerization conditions was studied by using a fractional factorial design. The final goal was to obtain an adequate device for use in controlled release tests, based on electrochemical potential control. For controlled release tests, Safranin was used as model drug and release curves (amount of drug vs. time) have shown that these blends are promising materials for this use. The optimized blends obtained were characterized by cyclic voltammetry and Raman spectroscopy.
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spelling Conducting polymer- hydrogel blends for electrochemically controlled drug release devicesfactorial designpolypyrrole-polyacrilamide blendsdrug deliveryelectrochemically controlled releaseBlends formed by electrochemical polymerization of polypyrrole (PPy) into polyacrylamide (PAAm) hydrogels were used as devices for controlled drug release. The influence of several parameters in the synthesis, such as type of hydrogel matrix and polymerization conditions was studied by using a fractional factorial design. The final goal was to obtain an adequate device for use in controlled release tests, based on electrochemical potential control. For controlled release tests, Safranin was used as model drug and release curves (amount of drug vs. time) have shown that these blends are promising materials for this use. The optimized blends obtained were characterized by cyclic voltammetry and Raman spectroscopy.Sociedade Brasileira de Química2008-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532008000400004Journal of the Brazilian Chemical Society v.19 n.4 2008reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532008000400004info:eu-repo/semantics/openAccessBarthus,Rosângela C.Lira,Luiz M.Torresi,Susana I. Córdoba deeng2008-06-11T00:00:00Zoai:scielo:S0103-50532008000400004Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2008-06-11T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Conducting polymer- hydrogel blends for electrochemically controlled drug release devices
title Conducting polymer- hydrogel blends for electrochemically controlled drug release devices
spellingShingle Conducting polymer- hydrogel blends for electrochemically controlled drug release devices
Barthus,Rosângela C.
factorial design
polypyrrole-polyacrilamide blends
drug delivery
electrochemically controlled release
title_short Conducting polymer- hydrogel blends for electrochemically controlled drug release devices
title_full Conducting polymer- hydrogel blends for electrochemically controlled drug release devices
title_fullStr Conducting polymer- hydrogel blends for electrochemically controlled drug release devices
title_full_unstemmed Conducting polymer- hydrogel blends for electrochemically controlled drug release devices
title_sort Conducting polymer- hydrogel blends for electrochemically controlled drug release devices
author Barthus,Rosângela C.
author_facet Barthus,Rosângela C.
Lira,Luiz M.
Torresi,Susana I. Córdoba de
author_role author
author2 Lira,Luiz M.
Torresi,Susana I. Córdoba de
author2_role author
author
dc.contributor.author.fl_str_mv Barthus,Rosângela C.
Lira,Luiz M.
Torresi,Susana I. Córdoba de
dc.subject.por.fl_str_mv factorial design
polypyrrole-polyacrilamide blends
drug delivery
electrochemically controlled release
topic factorial design
polypyrrole-polyacrilamide blends
drug delivery
electrochemically controlled release
description Blends formed by electrochemical polymerization of polypyrrole (PPy) into polyacrylamide (PAAm) hydrogels were used as devices for controlled drug release. The influence of several parameters in the synthesis, such as type of hydrogel matrix and polymerization conditions was studied by using a fractional factorial design. The final goal was to obtain an adequate device for use in controlled release tests, based on electrochemical potential control. For controlled release tests, Safranin was used as model drug and release curves (amount of drug vs. time) have shown that these blends are promising materials for this use. The optimized blends obtained were characterized by cyclic voltammetry and Raman spectroscopy.
publishDate 2008
dc.date.none.fl_str_mv 2008-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532008000400004
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532008000400004
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-50532008000400004
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.19 n.4 2008
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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