"Sweet Chemistry": a Green Way for Obtaining Selenium Nanoparticles Active against Cancer Cells

• Autor(a) principal: Vieira,Adriana P.
• Data de Publicação: 2017
• Outros Autores: Stein,Erika M., Andreguetti,Daniel X., Cebrián-Torrejón,Gerardo, Doménech-Carbó,Antonio, Colepicolo,Pio, Ferreira,Ana Maria D. C.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Journal of the Brazilian Chemical Society (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532017001002021
• topic: selenium nanoparticles; D-fructose; cancer cells; green chemistry; cytotoxicity

We present an environment friendly synthesis of selenium nanoparticles and the study of their cytotoxic activity against uterine sarcoma cancer and fibroblasts cells. Amorphous selenium (a-SeNPs) and trigonal selenium (t-SeNPs) were synthesized using D-fructose as the reducing agent and characterized by high-resolution transmission electron microscopy (HRTEM), energy-dispersive X-ray spectroscopy (EDX), powder X-ray diffraction analysis (XRD), inductively coupled plasma optical emission spectrometry (ICP OES), dynamic light scattering (DLS) to obtain zeta potential values and cyclic voltammetry (CV). Particularly, a-SeNPs presented high toxicity toward the resistant cancer cell line MES-SA/Dx5 and its parental MES-SA line. However, they are not toxic against P4 fibroblast cells in comparative studies.