Chemistry and bioactivity of Haplopappus remyanus ("bailahuen"), a chilean medicinal plant
Autor(a) principal: | |
---|---|
Data de Publicação: | 2011 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of the Brazilian Chemical Society (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532011001200015 |
Resumo: | Chromatography on the resinous extract of aerial parts of Haplopappus remyanus led to the isolation of 18-acetoxy-labda-7,13E-dien-15-oic acid along with the monoterpene derivatives 9-hydroxy-α-terpineol, 9-benzoyloxy-α-terpineol,7-hydroxy-9-benzoyloxy-α-terpineoland 9-benzoyloxy-(1-formyl)-α-terpineol. Structures for the new compounds are proposed on spectroscopic evidence. The presence of quercetin and five other known flavonoids identified in this study could account for the reported high antioxidant activity and the moderate topic anti-inflammatory effect on induced ear oedema. MTT assay with CCRF-CEM tumor cells showed 50% of the cytotoxic activity displayed by doxorubicin under the same conditions. Quantitative differences in chemical composition were detected in comparison with previous studies of the species that could be attributed to environmental factors. |
id |
SBQ-2_d7358f9f1e33c3c18bbe75cee274e010 |
---|---|
oai_identifier_str |
oai:scielo:S0103-50532011001200015 |
network_acronym_str |
SBQ-2 |
network_name_str |
Journal of the Brazilian Chemical Society (Online) |
repository_id_str |
|
spelling |
Chemistry and bioactivity of Haplopappus remyanus ("bailahuen"), a chilean medicinal plantHaplopappus remyanusanti-inflammatory activitycytotoxic activity9-hydroxy-α-terpineol estersflavonoidsChromatography on the resinous extract of aerial parts of Haplopappus remyanus led to the isolation of 18-acetoxy-labda-7,13E-dien-15-oic acid along with the monoterpene derivatives 9-hydroxy-α-terpineol, 9-benzoyloxy-α-terpineol,7-hydroxy-9-benzoyloxy-α-terpineoland 9-benzoyloxy-(1-formyl)-α-terpineol. Structures for the new compounds are proposed on spectroscopic evidence. The presence of quercetin and five other known flavonoids identified in this study could account for the reported high antioxidant activity and the moderate topic anti-inflammatory effect on induced ear oedema. MTT assay with CCRF-CEM tumor cells showed 50% of the cytotoxic activity displayed by doxorubicin under the same conditions. Quantitative differences in chemical composition were detected in comparison with previous studies of the species that could be attributed to environmental factors.Sociedade Brasileira de Química2011-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532011001200015Journal of the Brazilian Chemical Society v.22 n.12 2011reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532011001200015info:eu-repo/semantics/openAccessFaini,FrancescaTorres,RenéRodilla,Jesús M.Labbé,CeciliaDelporte,CarlaJaña,Fabiáneng2012-01-05T00:00:00Zoai:scielo:S0103-50532011001200015Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2012-01-05T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
Chemistry and bioactivity of Haplopappus remyanus ("bailahuen"), a chilean medicinal plant |
title |
Chemistry and bioactivity of Haplopappus remyanus ("bailahuen"), a chilean medicinal plant |
spellingShingle |
Chemistry and bioactivity of Haplopappus remyanus ("bailahuen"), a chilean medicinal plant Faini,Francesca Haplopappus remyanus anti-inflammatory activity cytotoxic activity 9-hydroxy-α-terpineol esters flavonoids |
title_short |
Chemistry and bioactivity of Haplopappus remyanus ("bailahuen"), a chilean medicinal plant |
title_full |
Chemistry and bioactivity of Haplopappus remyanus ("bailahuen"), a chilean medicinal plant |
title_fullStr |
Chemistry and bioactivity of Haplopappus remyanus ("bailahuen"), a chilean medicinal plant |
title_full_unstemmed |
Chemistry and bioactivity of Haplopappus remyanus ("bailahuen"), a chilean medicinal plant |
title_sort |
Chemistry and bioactivity of Haplopappus remyanus ("bailahuen"), a chilean medicinal plant |
author |
Faini,Francesca |
author_facet |
Faini,Francesca Torres,René Rodilla,Jesús M. Labbé,Cecilia Delporte,Carla Jaña,Fabián |
author_role |
author |
author2 |
Torres,René Rodilla,Jesús M. Labbé,Cecilia Delporte,Carla Jaña,Fabián |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Faini,Francesca Torres,René Rodilla,Jesús M. Labbé,Cecilia Delporte,Carla Jaña,Fabián |
dc.subject.por.fl_str_mv |
Haplopappus remyanus anti-inflammatory activity cytotoxic activity 9-hydroxy-α-terpineol esters flavonoids |
topic |
Haplopappus remyanus anti-inflammatory activity cytotoxic activity 9-hydroxy-α-terpineol esters flavonoids |
description |
Chromatography on the resinous extract of aerial parts of Haplopappus remyanus led to the isolation of 18-acetoxy-labda-7,13E-dien-15-oic acid along with the monoterpene derivatives 9-hydroxy-α-terpineol, 9-benzoyloxy-α-terpineol,7-hydroxy-9-benzoyloxy-α-terpineoland 9-benzoyloxy-(1-formyl)-α-terpineol. Structures for the new compounds are proposed on spectroscopic evidence. The presence of quercetin and five other known flavonoids identified in this study could account for the reported high antioxidant activity and the moderate topic anti-inflammatory effect on induced ear oedema. MTT assay with CCRF-CEM tumor cells showed 50% of the cytotoxic activity displayed by doxorubicin under the same conditions. Quantitative differences in chemical composition were detected in comparison with previous studies of the species that could be attributed to environmental factors. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532011001200015 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532011001200015 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0103-50532011001200015 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Journal of the Brazilian Chemical Society v.22 n.12 2011 reponame:Journal of the Brazilian Chemical Society (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Journal of the Brazilian Chemical Society (Online) |
collection |
Journal of the Brazilian Chemical Society (Online) |
repository.name.fl_str_mv |
Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
||office@jbcs.sbq.org.br |
_version_ |
1750318172778528768 |