Electrochemical behavior of 1-ferrocenyl-3-phenyl-2-propen-1-one on glassy carbon electrode and evaluation of its interaction parameters with DNA
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of the Brazilian Chemical Society (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532010000300008 |
Resumo: | The electrochemical behavior of 1-ferrocenyl-3-phenyl-2-propen-1-one (ferrocenylone) and its interaction with DNA was studied by a glassy carbon electrode using cyclic voltammetry (CV) technique. The results from CV were supported by UV-Visible spectroscopy performed under the similar conditions. The positive peak potential shift in CV and the bathochromic shift in the UV-Vis absorption spectra suggested an intercalative mode of binding. The binding constant (K = 1.39 ± 0.02 × 10(4) mol-1 L) and the binding site size (0.53 bp) were obtained from voltammetric data which leads to a standard Gibbs free energy change (ΔGº= -RT lnK) of -23.64 kJ mol-1 and hence indicated the spontaneity of the binding interaction. The values of binding constants obtained from UV-Vis absorption and CV measurements, 1.26 ± 0.01 × 10(4) and 1.39 ± 0.02 × 10(4) mol-1 L respectively, were in close agreement. |
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Electrochemical behavior of 1-ferrocenyl-3-phenyl-2-propen-1-one on glassy carbon electrode and evaluation of its interaction parameters with DNAcyclic voltammetryUV-VisDNAchalconebinding constantThe electrochemical behavior of 1-ferrocenyl-3-phenyl-2-propen-1-one (ferrocenylone) and its interaction with DNA was studied by a glassy carbon electrode using cyclic voltammetry (CV) technique. The results from CV were supported by UV-Visible spectroscopy performed under the similar conditions. The positive peak potential shift in CV and the bathochromic shift in the UV-Vis absorption spectra suggested an intercalative mode of binding. The binding constant (K = 1.39 ± 0.02 × 10(4) mol-1 L) and the binding site size (0.53 bp) were obtained from voltammetric data which leads to a standard Gibbs free energy change (ΔGº= -RT lnK) of -23.64 kJ mol-1 and hence indicated the spontaneity of the binding interaction. The values of binding constants obtained from UV-Vis absorption and CV measurements, 1.26 ± 0.01 × 10(4) and 1.39 ± 0.02 × 10(4) mol-1 L respectively, were in close agreement.Sociedade Brasileira de Química2010-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532010000300008Journal of the Brazilian Chemical Society v.21 n.3 2010reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532010000300008info:eu-repo/semantics/openAccessShah,AfzalQureshi,RumanaKhan,Asad M.Khera,Rasheed AAnsari,Farzana L.eng2010-04-30T00:00:00Zoai:scielo:S0103-50532010000300008Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2010-04-30T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
Electrochemical behavior of 1-ferrocenyl-3-phenyl-2-propen-1-one on glassy carbon electrode and evaluation of its interaction parameters with DNA |
title |
Electrochemical behavior of 1-ferrocenyl-3-phenyl-2-propen-1-one on glassy carbon electrode and evaluation of its interaction parameters with DNA |
spellingShingle |
Electrochemical behavior of 1-ferrocenyl-3-phenyl-2-propen-1-one on glassy carbon electrode and evaluation of its interaction parameters with DNA Shah,Afzal cyclic voltammetry UV-Vis DNA chalcone binding constant |
title_short |
Electrochemical behavior of 1-ferrocenyl-3-phenyl-2-propen-1-one on glassy carbon electrode and evaluation of its interaction parameters with DNA |
title_full |
Electrochemical behavior of 1-ferrocenyl-3-phenyl-2-propen-1-one on glassy carbon electrode and evaluation of its interaction parameters with DNA |
title_fullStr |
Electrochemical behavior of 1-ferrocenyl-3-phenyl-2-propen-1-one on glassy carbon electrode and evaluation of its interaction parameters with DNA |
title_full_unstemmed |
Electrochemical behavior of 1-ferrocenyl-3-phenyl-2-propen-1-one on glassy carbon electrode and evaluation of its interaction parameters with DNA |
title_sort |
Electrochemical behavior of 1-ferrocenyl-3-phenyl-2-propen-1-one on glassy carbon electrode and evaluation of its interaction parameters with DNA |
author |
Shah,Afzal |
author_facet |
Shah,Afzal Qureshi,Rumana Khan,Asad M. Khera,Rasheed A Ansari,Farzana L. |
author_role |
author |
author2 |
Qureshi,Rumana Khan,Asad M. Khera,Rasheed A Ansari,Farzana L. |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Shah,Afzal Qureshi,Rumana Khan,Asad M. Khera,Rasheed A Ansari,Farzana L. |
dc.subject.por.fl_str_mv |
cyclic voltammetry UV-Vis DNA chalcone binding constant |
topic |
cyclic voltammetry UV-Vis DNA chalcone binding constant |
description |
The electrochemical behavior of 1-ferrocenyl-3-phenyl-2-propen-1-one (ferrocenylone) and its interaction with DNA was studied by a glassy carbon electrode using cyclic voltammetry (CV) technique. The results from CV were supported by UV-Visible spectroscopy performed under the similar conditions. The positive peak potential shift in CV and the bathochromic shift in the UV-Vis absorption spectra suggested an intercalative mode of binding. The binding constant (K = 1.39 ± 0.02 × 10(4) mol-1 L) and the binding site size (0.53 bp) were obtained from voltammetric data which leads to a standard Gibbs free energy change (ΔGº= -RT lnK) of -23.64 kJ mol-1 and hence indicated the spontaneity of the binding interaction. The values of binding constants obtained from UV-Vis absorption and CV measurements, 1.26 ± 0.01 × 10(4) and 1.39 ± 0.02 × 10(4) mol-1 L respectively, were in close agreement. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532010000300008 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532010000300008 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0103-50532010000300008 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Journal of the Brazilian Chemical Society v.21 n.3 2010 reponame:Journal of the Brazilian Chemical Society (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Journal of the Brazilian Chemical Society (Online) |
collection |
Journal of the Brazilian Chemical Society (Online) |
repository.name.fl_str_mv |
Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
||office@jbcs.sbq.org.br |
_version_ |
1750318170658308096 |