Inhibitory and enzyme-kinetic Investigation of chelerythrine and lupeol Isolated from Zanthoxylum rhoifolium against krait snake venom acetylcholinesterase

Detalhes bibliográficos
Autor(a) principal: Ahmad,Mustaq
Data de Publicação: 2014
Outros Autores: Weber,Andréia D., Zanon,Graciane, Tavares,Luciana de C., Ilha,Vinicius, Dalcol,Ionara I., F. Morel,Ademir
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532014000100012
Resumo: The in vitro activity of chelerythrine and lupeol, two metabolites isolated from Zanthoxylum rhoifolium were studied against the venom of the snake Bungarus sindanus (Elapidae). The venom, which is highly toxic to humans, consists mainly by the enzyme acetylcholinesterase (AChE). Both compounds showed activity against the venom, and the alkaloid chelerythrine presented higher activity than did triterpene lupeol.
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spelling Inhibitory and enzyme-kinetic Investigation of chelerythrine and lupeol Isolated from Zanthoxylum rhoifolium against krait snake venom acetylcholinesteraseZanthoxylum rhoifoliumchelerythrinelupeolinhibition of AChEvenom of the Bungarus sindanusThe in vitro activity of chelerythrine and lupeol, two metabolites isolated from Zanthoxylum rhoifolium were studied against the venom of the snake Bungarus sindanus (Elapidae). The venom, which is highly toxic to humans, consists mainly by the enzyme acetylcholinesterase (AChE). Both compounds showed activity against the venom, and the alkaloid chelerythrine presented higher activity than did triterpene lupeol.Sociedade Brasileira de Química2014-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532014000100012Journal of the Brazilian Chemical Society v.25 n.1 2014reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.5935/0103-5053.20130274info:eu-repo/semantics/openAccessAhmad,MustaqWeber,Andréia D.Zanon,GracianeTavares,Luciana de C.Ilha,ViniciusDalcol,Ionara I.F. Morel,Ademireng2014-01-28T00:00:00Zoai:scielo:S0103-50532014000100012Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2014-01-28T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Inhibitory and enzyme-kinetic Investigation of chelerythrine and lupeol Isolated from Zanthoxylum rhoifolium against krait snake venom acetylcholinesterase
title Inhibitory and enzyme-kinetic Investigation of chelerythrine and lupeol Isolated from Zanthoxylum rhoifolium against krait snake venom acetylcholinesterase
spellingShingle Inhibitory and enzyme-kinetic Investigation of chelerythrine and lupeol Isolated from Zanthoxylum rhoifolium against krait snake venom acetylcholinesterase
Ahmad,Mustaq
Zanthoxylum rhoifolium
chelerythrine
lupeol
inhibition of AChE
venom of the Bungarus sindanus
title_short Inhibitory and enzyme-kinetic Investigation of chelerythrine and lupeol Isolated from Zanthoxylum rhoifolium against krait snake venom acetylcholinesterase
title_full Inhibitory and enzyme-kinetic Investigation of chelerythrine and lupeol Isolated from Zanthoxylum rhoifolium against krait snake venom acetylcholinesterase
title_fullStr Inhibitory and enzyme-kinetic Investigation of chelerythrine and lupeol Isolated from Zanthoxylum rhoifolium against krait snake venom acetylcholinesterase
title_full_unstemmed Inhibitory and enzyme-kinetic Investigation of chelerythrine and lupeol Isolated from Zanthoxylum rhoifolium against krait snake venom acetylcholinesterase
title_sort Inhibitory and enzyme-kinetic Investigation of chelerythrine and lupeol Isolated from Zanthoxylum rhoifolium against krait snake venom acetylcholinesterase
author Ahmad,Mustaq
author_facet Ahmad,Mustaq
Weber,Andréia D.
Zanon,Graciane
Tavares,Luciana de C.
Ilha,Vinicius
Dalcol,Ionara I.
F. Morel,Ademir
author_role author
author2 Weber,Andréia D.
Zanon,Graciane
Tavares,Luciana de C.
Ilha,Vinicius
Dalcol,Ionara I.
F. Morel,Ademir
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Ahmad,Mustaq
Weber,Andréia D.
Zanon,Graciane
Tavares,Luciana de C.
Ilha,Vinicius
Dalcol,Ionara I.
F. Morel,Ademir
dc.subject.por.fl_str_mv Zanthoxylum rhoifolium
chelerythrine
lupeol
inhibition of AChE
venom of the Bungarus sindanus
topic Zanthoxylum rhoifolium
chelerythrine
lupeol
inhibition of AChE
venom of the Bungarus sindanus
description The in vitro activity of chelerythrine and lupeol, two metabolites isolated from Zanthoxylum rhoifolium were studied against the venom of the snake Bungarus sindanus (Elapidae). The venom, which is highly toxic to humans, consists mainly by the enzyme acetylcholinesterase (AChE). Both compounds showed activity against the venom, and the alkaloid chelerythrine presented higher activity than did triterpene lupeol.
publishDate 2014
dc.date.none.fl_str_mv 2014-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532014000100012
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532014000100012
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/0103-5053.20130274
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.25 n.1 2014
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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