Inhibitory and enzyme-kinetic Investigation of chelerythrine and lupeol Isolated from Zanthoxylum rhoifolium against krait snake venom acetylcholinesterase
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of the Brazilian Chemical Society (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532014000100012 |
Resumo: | The in vitro activity of chelerythrine and lupeol, two metabolites isolated from Zanthoxylum rhoifolium were studied against the venom of the snake Bungarus sindanus (Elapidae). The venom, which is highly toxic to humans, consists mainly by the enzyme acetylcholinesterase (AChE). Both compounds showed activity against the venom, and the alkaloid chelerythrine presented higher activity than did triterpene lupeol. |
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Journal of the Brazilian Chemical Society (Online) |
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Inhibitory and enzyme-kinetic Investigation of chelerythrine and lupeol Isolated from Zanthoxylum rhoifolium against krait snake venom acetylcholinesteraseZanthoxylum rhoifoliumchelerythrinelupeolinhibition of AChEvenom of the Bungarus sindanusThe in vitro activity of chelerythrine and lupeol, two metabolites isolated from Zanthoxylum rhoifolium were studied against the venom of the snake Bungarus sindanus (Elapidae). The venom, which is highly toxic to humans, consists mainly by the enzyme acetylcholinesterase (AChE). Both compounds showed activity against the venom, and the alkaloid chelerythrine presented higher activity than did triterpene lupeol.Sociedade Brasileira de Química2014-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532014000100012Journal of the Brazilian Chemical Society v.25 n.1 2014reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.5935/0103-5053.20130274info:eu-repo/semantics/openAccessAhmad,MustaqWeber,Andréia D.Zanon,GracianeTavares,Luciana de C.Ilha,ViniciusDalcol,Ionara I.F. Morel,Ademireng2014-01-28T00:00:00Zoai:scielo:S0103-50532014000100012Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2014-01-28T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
Inhibitory and enzyme-kinetic Investigation of chelerythrine and lupeol Isolated from Zanthoxylum rhoifolium against krait snake venom acetylcholinesterase |
title |
Inhibitory and enzyme-kinetic Investigation of chelerythrine and lupeol Isolated from Zanthoxylum rhoifolium against krait snake venom acetylcholinesterase |
spellingShingle |
Inhibitory and enzyme-kinetic Investigation of chelerythrine and lupeol Isolated from Zanthoxylum rhoifolium against krait snake venom acetylcholinesterase Ahmad,Mustaq Zanthoxylum rhoifolium chelerythrine lupeol inhibition of AChE venom of the Bungarus sindanus |
title_short |
Inhibitory and enzyme-kinetic Investigation of chelerythrine and lupeol Isolated from Zanthoxylum rhoifolium against krait snake venom acetylcholinesterase |
title_full |
Inhibitory and enzyme-kinetic Investigation of chelerythrine and lupeol Isolated from Zanthoxylum rhoifolium against krait snake venom acetylcholinesterase |
title_fullStr |
Inhibitory and enzyme-kinetic Investigation of chelerythrine and lupeol Isolated from Zanthoxylum rhoifolium against krait snake venom acetylcholinesterase |
title_full_unstemmed |
Inhibitory and enzyme-kinetic Investigation of chelerythrine and lupeol Isolated from Zanthoxylum rhoifolium against krait snake venom acetylcholinesterase |
title_sort |
Inhibitory and enzyme-kinetic Investigation of chelerythrine and lupeol Isolated from Zanthoxylum rhoifolium against krait snake venom acetylcholinesterase |
author |
Ahmad,Mustaq |
author_facet |
Ahmad,Mustaq Weber,Andréia D. Zanon,Graciane Tavares,Luciana de C. Ilha,Vinicius Dalcol,Ionara I. F. Morel,Ademir |
author_role |
author |
author2 |
Weber,Andréia D. Zanon,Graciane Tavares,Luciana de C. Ilha,Vinicius Dalcol,Ionara I. F. Morel,Ademir |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Ahmad,Mustaq Weber,Andréia D. Zanon,Graciane Tavares,Luciana de C. Ilha,Vinicius Dalcol,Ionara I. F. Morel,Ademir |
dc.subject.por.fl_str_mv |
Zanthoxylum rhoifolium chelerythrine lupeol inhibition of AChE venom of the Bungarus sindanus |
topic |
Zanthoxylum rhoifolium chelerythrine lupeol inhibition of AChE venom of the Bungarus sindanus |
description |
The in vitro activity of chelerythrine and lupeol, two metabolites isolated from Zanthoxylum rhoifolium were studied against the venom of the snake Bungarus sindanus (Elapidae). The venom, which is highly toxic to humans, consists mainly by the enzyme acetylcholinesterase (AChE). Both compounds showed activity against the venom, and the alkaloid chelerythrine presented higher activity than did triterpene lupeol. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532014000100012 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532014000100012 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.5935/0103-5053.20130274 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Journal of the Brazilian Chemical Society v.25 n.1 2014 reponame:Journal of the Brazilian Chemical Society (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Journal of the Brazilian Chemical Society (Online) |
collection |
Journal of the Brazilian Chemical Society (Online) |
repository.name.fl_str_mv |
Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
||office@jbcs.sbq.org.br |
_version_ |
1750318175684132864 |