Potential Insecticidal Activity of Steroidal C-17 Pyrazolinyl Derivatives
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , |
Tipo de documento: | Relatório |
Idioma: | eng |
Título da fonte: | Journal of the Brazilian Chemical Society (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532015000200389 |
Resumo: | Agrochemical research, over the last two decades, has resulted in the discovery of chemically novel insecticides, of which steroids-based compounds that mimic the action of hormones have been considered as safe insecticides. In this study, eight steroidal C-17 pyrazolinyl derivatives were resynthesized through molecular hybridization and their insecticidal activities against 4thinstar larvae of Mythimna separate were evaluated. These results showed that some compounds exhibited significant insecticidal activities and the susceptibility assays were expressed as the median lethal dose (LD50), of which one of the compounds exerted the most potent insecticidal activity (LD50 = 296 µg g-1), comparable to that of the natural product insecticide, celangulatin V (LD50 = 260 µg g-1). This strategy led to a promising candidate for the development of new steroidal insecticidal agents. |
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Potential Insecticidal Activity of Steroidal C-17 Pyrazolinyl Derivativessteroidprogesteronepyrazolineinsecticidal activityAgrochemical research, over the last two decades, has resulted in the discovery of chemically novel insecticides, of which steroids-based compounds that mimic the action of hormones have been considered as safe insecticides. In this study, eight steroidal C-17 pyrazolinyl derivatives were resynthesized through molecular hybridization and their insecticidal activities against 4thinstar larvae of Mythimna separate were evaluated. These results showed that some compounds exhibited significant insecticidal activities and the susceptibility assays were expressed as the median lethal dose (LD50), of which one of the compounds exerted the most potent insecticidal activity (LD50 = 296 µg g-1), comparable to that of the natural product insecticide, celangulatin V (LD50 = 260 µg g-1). This strategy led to a promising candidate for the development of new steroidal insecticidal agents.Sociedade Brasileira de Química2015-02-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532015000200389Journal of the Brazilian Chemical Society v.26 n.2 2015reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.5935/0103-5053.20140248info:eu-repo/semantics/openAccessFan,Ning-JuanGao,Jin-MingTang,Jiang-Jiangeng2015-10-26T00:00:00Zoai:scielo:S0103-50532015000200389Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2015-10-26T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
Potential Insecticidal Activity of Steroidal C-17 Pyrazolinyl Derivatives |
title |
Potential Insecticidal Activity of Steroidal C-17 Pyrazolinyl Derivatives |
spellingShingle |
Potential Insecticidal Activity of Steroidal C-17 Pyrazolinyl Derivatives Fan,Ning-Juan steroid progesterone pyrazoline insecticidal activity |
title_short |
Potential Insecticidal Activity of Steroidal C-17 Pyrazolinyl Derivatives |
title_full |
Potential Insecticidal Activity of Steroidal C-17 Pyrazolinyl Derivatives |
title_fullStr |
Potential Insecticidal Activity of Steroidal C-17 Pyrazolinyl Derivatives |
title_full_unstemmed |
Potential Insecticidal Activity of Steroidal C-17 Pyrazolinyl Derivatives |
title_sort |
Potential Insecticidal Activity of Steroidal C-17 Pyrazolinyl Derivatives |
author |
Fan,Ning-Juan |
author_facet |
Fan,Ning-Juan Gao,Jin-Ming Tang,Jiang-Jiang |
author_role |
author |
author2 |
Gao,Jin-Ming Tang,Jiang-Jiang |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Fan,Ning-Juan Gao,Jin-Ming Tang,Jiang-Jiang |
dc.subject.por.fl_str_mv |
steroid progesterone pyrazoline insecticidal activity |
topic |
steroid progesterone pyrazoline insecticidal activity |
description |
Agrochemical research, over the last two decades, has resulted in the discovery of chemically novel insecticides, of which steroids-based compounds that mimic the action of hormones have been considered as safe insecticides. In this study, eight steroidal C-17 pyrazolinyl derivatives were resynthesized through molecular hybridization and their insecticidal activities against 4thinstar larvae of Mythimna separate were evaluated. These results showed that some compounds exhibited significant insecticidal activities and the susceptibility assays were expressed as the median lethal dose (LD50), of which one of the compounds exerted the most potent insecticidal activity (LD50 = 296 µg g-1), comparable to that of the natural product insecticide, celangulatin V (LD50 = 260 µg g-1). This strategy led to a promising candidate for the development of new steroidal insecticidal agents. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-02-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/report |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
report |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532015000200389 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532015000200389 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.5935/0103-5053.20140248 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Journal of the Brazilian Chemical Society v.26 n.2 2015 reponame:Journal of the Brazilian Chemical Society (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Journal of the Brazilian Chemical Society (Online) |
collection |
Journal of the Brazilian Chemical Society (Online) |
repository.name.fl_str_mv |
Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
||office@jbcs.sbq.org.br |
_version_ |
1750318176974929920 |