Graphene Oxides Coated Paper as a Substrate to Paper Spray Ionization Mass Spectrometry for Creatinine Determination in Urine Samples

• Autor(a) principal: Fernandes,Aline R.
• Data de Publicação: 2019
• Outros Autores: Bernardo,Ricardo A., Carvalho,Thays C. de, Vaz,Boniek G., Chaves,Andréa R.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Journal of the Brazilian Chemical Society (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532019000501074
• topic: paper spray ionization; graphene oxide; creatinine; urine; mass spectrometry

Paper spray ionization (PSI) is a promising analytical tool for direct analysis in mass spectrometry (MS). However, this technique usually uses chromatographic paper, which rarely accomplishes a stable MS signal and could vary with the sample matrix effect. In the present study, the application of graphene oxides (GO) was scrutinized as modifier paper substrate for PSI-MS methods. The developed substrate efficiency was evaluated towards creatinine determination in urine samples. The GO-PSI-MS developed method for creatinine in urine samples showed linearity in the range of 0.1 to 3.4 ppm with R2 = 0.9991. The precision was evaluated and the values were between 1.1 to 6.8% and the accuracy above 96.8%. The limit of quantification (LOQ) and limit of detection (LOD) were 0.05 and 0.17 ppm, respectively. The GO-PSI developed was compared to conventional chromatographic paper for PSI-MS methods, and the results showed that the modified paper with GO bolsters method linearity, precision, and LOQ values.